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Role of Hypoxia-Inducible Factor (HIF) in the Initiation of Cancer and Its Therapeutic Inhibitors

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Role of Transcription Factors in Gastrointestinal Malignancies

Abstract

The inadequate oxygen (O2) supply to a large extent alters the cellular microenvironment and results in hypoxia or even anoxia. Hypoxia-inducible factor (HIF) facilitates the cellular response to hypoxia. HIF, a heterodimer composed of two subunits, the subunit α and subunit β, is involved in several signaling pathways which involves both survival and death pathways, their activation and regulation. HIF is believed to be the best molecular target in the treatment of cancer, and also numerous inhibitors for HIF-1α are available today. This chapter explains the HIF-1α role in cancer and its therapeutic applications that potentially target HIF pathway.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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  1. Department of Biochemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India

    Sasidhar Eda & Rajeswari Jinka

  2. Department of Biotechnology & Bioinformatics, Yogi Vemana University, Kadapa, Andhra Pradesh, India

    Ramakrishna Vadde

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    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Eda, S., Vadde, R., Jinka, R. (2017). Role of Hypoxia-Inducible Factor (HIF) in the Initiation of Cancer and Its Therapeutic Inhibitors. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_10

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