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Anti-inflammatory Molecules: Immune System Mediators

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Bioresources and Bioprocess in Biotechnology

Abstract

Inflammation typifies the chief defensive mechanism against infection or injury. However, its obnoxious activation often elicits exaggerated immune response and the onset of clinically relevant detrimental responses. Suppression of inflammatory response by means of anti-inflammatory molecules is therefore weighed as a pivotal therapeutic solution to a wide range of diseases. The quest for newer and vital anti-inflammatory molecules has been considered as an active research vista for the development of potential drug candidates for a variety of pathological conditions. Inflammation and immune responses are inseparably linked in many instances, where the persisting inflammatory response serves as the key trigger for immune disorders. The immune system comprises immune cells and immunoglobulins, which are the major mediators of defensive response against obnoxious stimuli. Several anti-inflammatory molecules have been found to ameliorate immune reaction underlying many pathogenesis, via directly regulating production/function/activation of the prime components of the immune system and limit tissue damage. This chapter provides an insight into the ability of such anti-inflammatory molecules which target components of the immune system. The interplay of adaptive immunity and inflammatory mechanism in terms of chronic inflammatory disease pathogenesis is critically evaluated and demonstrated. An effort has been made to explain how this approach of inhibiting inflammatory targets qualifies as a potent therapeutic solution for immune disorders and transplant rejection. The emphasis is on identifying plausible anti-inflammatory agents targeting immune system mediators as a logical strategy for novel and efficient therapeutic interventions.

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Authors and Affiliations

  1. Inter University Centre for Bioscience, Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur, 6706661, Kerala, India

    B. C. Bhavya & Madathilkovilakath Haridas

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  1. B. C. Bhavya
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Correspondence to Madathilkovilakath Haridas .

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  1. Microbiology Division, Jawaharlal Nehru Tropical Botanic Garden, Thiruvananthapuram, Kerala, India

    Shiburaj Sugathan

  2. Microbiology Division, Jawaharlal Nehru Tropical Botanic Garden, Thiruvananthapuram, Kerala, India

    N. S. Pradeep

  3. Inter University Centre for Bioscience, Department of Biotechnology and Microbiology, School of Life Sciences, Kannur University, Kannur, Kerala, India

    Sabu Abdulhameed

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Bhavya, B.C., Haridas, M. (2017). Anti-inflammatory Molecules: Immune System Mediators. In: Sugathan, S., Pradeep, N., Abdulhameed, S. (eds) Bioresources and Bioprocess in Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-4284-3_10

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