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Structure and function of interleukin-22 and other members of the interleukin-10 family

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Abstract

The IL-10 family of cytokines is comprised of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and IFN-λs (IL-28A, IL-28B, and IL-29). The IL-10 family members bind to shared class II cytokine receptor chains that associate in various combinations in heterodimeric complexes. Upon interleukin/receptor complex formation, these proteins switch on the Jak/STAT pathway and elicit pleiotropic biological responses whose variety sharply contrasts with their structural similarities. IL-10 family members are involved in several human diseases and health conditions and hence their structural analyses may provide valuable information to design specific therapeutic strategies. In this review, we describe the human interleukin-10 family of cytokines, focusing on their structures and functions, with particular attention given to IL-22 and IL-10. We report on the recently published structures of IL-10 cytokine family members and their complexes with cognate transmembrane and soluble receptors as well as on interleukin physiology and physiopathology.

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  1. Instituto de Física de São Carlos, Universidade de São Paulo, Avenida Trabalhador São Carlense 400, São Carlos, SP, CEP 13566-590, Brazil

    Daniela Barretto Barbosa Trivella & Igor Polikarpov

  2. Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, Avenida Arlindo Béttio, 1000, Ermelino Matarazzo, São Paulo, SP, CEP 03828-000, Brazil

    José Ribamar Ferreira-Júnior

  3. Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium

    Laure Dumoutier & Jean-Christophe Renauld

  4. Experimental Medicine Unit, Christian de Duve Institute, Universite’ Catholique de Louvain, Brussels, Belgium

    Laure Dumoutier & Jean-Christophe Renauld

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  1. Daniela Barretto Barbosa Trivella
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Trivella, D.B.B., Ferreira-Júnior, J.R., Dumoutier, L. et al. Structure and function of interleukin-22 and other members of the interleukin-10 family. Cell. Mol. Life Sci. 67, 2909–2935 (2010). https://doi.org/10.1007/s00018-010-0380-0

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