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Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming

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The Long and Short Non-coding RNAs in Cancer Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 927))

Abstract

Since the description of the Warburg effect 90 years ago, metabolic reprogramming has been gradually recognized as a major hallmark of cancer cells. Mounting evidence now indicates that cancer is a kind of metabolic disease, quite distinct from conventional perception. While metabolic alterations in cancer cells have been extensively observed in glucose, lipid, and amino acid metabolisms, its underlying regulatory mechanisms are still poorly understood. Noncoding RNA, also known as the “dark matter in life,” functions through various mechanisms at RNA level regulating different biological pathways. The last two decades have witnessed the booming of noncoding RNA study on microRNA (miRNA), long noncoding RNA (lncRNA), circular RNA (circRNA), PIWI-interacting RNA (piRNA), etc. In this chapter, we will discuss the regulatory roles of noncoding RNAs on cancer metabolism.

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Abbreviations

G6P:

Glucose-6-phosphate

3PG:

3-Phosphoglucerate

PEP:

Phosphoenolpyruvate

Pyr:

Pyruvate

Lac:

Lactate

Ac-CoA:

Acetyl-CoA

Cit:

Citrate

α-KG:

α-Ketoglutarate

Glu:

Glutamine

Pro:

Proline

BCAAs:

Branched-chain amino acids

HMG-CoA:

3-Hydroxy-3-methylglutaryl-coenzyme A

MVA:

Mevalonic acid

IPP:

Isopentenyl pyrophosphate

SE:

Squalene epoxide

Chol:

Cholesterol

7-DHC:

7-Dehydrocholesterol

IGF1-R:

Insulin-like growth factor 1 receptor

GLUTs:

Glucose transporters

G6PC:

Glucose-6-phosphatase

HK2:

Hexokinase 2

G6PD:

Glucose-6-phosphate dehydrogenase

PKM2:

Pyruvate kinase M2

LDHA:

Lactate dehydrogenase A

PDK1:

Pyruvate dehydrogenase kinase 1

PDH:

Pyruvate dehydrogenase

ACLY:

ATP citrate lyase

FASN:

Fatty acid synthase

HMGCS1:

3-Hydroxy-3-methylglutaryl-CoA synthase 1

HMGCR:

3-Hydroxy-3-methylglutaryl-CoA reductase

DHCR7:

7-Dehydrocholesterol reductase

CPT1A:

Carnitine palmitoyltransferase 1A

GLS:

Glutaminase

POX:

Proline dehydrogenase

DBT:

Dihydrolipoyl branched-chain acyltransferase

SQLE:

Squalene epoxidase

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Acknowledgments

This work is supported in part by the National Basic Key Research Program of China (2014CB910600), National Science Foundation of China (31372148, 81530076, 31571472), Chinese Academy of Sciences (XDA01010404), and Research Fund for the Doctoral Program of Higher Education of China (2133402110014).

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  1. Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, and School of Life Science, University of Science and Technology of China, Hefei, 230027, China

    Dongdong Yang, Linchong Sun, Zhaoyong Li & Ping Gao

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Correspondence to Ping Gao .

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    Erwei Song

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Yang, D., Sun, L., Li, Z., Gao, P. (2016). Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming. In: Song, E. (eds) The Long and Short Non-coding RNAs in Cancer Biology. Advances in Experimental Medicine and Biology, vol 927. Springer, Singapore. https://doi.org/10.1007/978-981-10-1498-7_7

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