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Clinical Pharmacokinetic and Biopharmaceutical Aspects of Hypnotic Drug Therapy

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Sleep Research

Abstract

This chapter will deal with pharmacokinetic and biopharmaceutical aspects of hypnotic drug therapy. It will attempt to link the importance of drug elimination and drug distribution with duration. of drug action and the importance of biopharmaceutical factors with the onset. of drug action. Firstly some basic requirements which a hypnotic drug should fulfil in this respect will be defined.

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References

  1. Amrein, R., Cano, J. P., Hartmann, D., Ziegler, W. H. and Dubuis, R. (1979). Clinical and psychometric effects of flunitrazepam observed during the day in relation to pharmacokinetic data. This volume, Chapter 7

    Google Scholar 

  2. Amrein, R., Cano, J. P. and Hügin, W. (1976). Pharmakokinetische und pharmakodynamische Befunde nach einmaliger intravenöser, intramuskulärer und oraler Applikation von ‘Rohypnol’. In Hügin, Hossli and Gemperle (eds.), Bisherige Erfahrungen mit ‘Rohypnol’ (Flunitrazepam) in der Anästhesiologie und Intensivtherpie., pp. 39–56. (Basle: Editiones Roche)

    Google Scholar 

  3. Bixler, E. O., Kales, A., Soldatos, C. R. and Kales, J. D. (1977). Flunitrazepam, an investigational hypnotic drug: sleep laboratory evaluations. J. Clin. Pharmacol., 17., 569

    Article  PubMed  CAS  Google Scholar 

  4. Boxenbaum, H. G., Geitner, K. A., Jack, M. L., Dixon, W. R., Spiegel, H. E., Symington, J., Christian, R., Moore, J. D., Weissman, L. and Kaplan, S. A. (1977). Pharmacokinetic and biopharmaceutic profile of chlordiazepoxide HCl in healthy subjects: single-dose studies by the intravenous, intramuscular and oral routes. J. Pharmacokinet. Biopharm., 5., 3

    Article  PubMed  CAS  Google Scholar 

  5. Breimer, D. D. (1975). Reclassification of barbiturates according to their pharmacokinetic behaviour in humans. Presented at the 35th International Congress of Pharmaceutical Sciences., September 3–8, Dublin

    Google Scholar 

  6. Breimer, D. D. (1976). Biologische gelijkwaardigheid van geneesmiddelen: een kwaliteitseis. Pharm. Weekbl., 111., 1121

    CAS  Google Scholar 

  7. Breimer, D. D. (1976). Pharmacokinetic and biopharmaceutical aspects of hypnotic drug therapy. In Gouveia, Tognoni and van der Kleijn (eds.), Clinical Pharmacy and Clinical Pharmacology., pp. 17–42. (Amsterdam: Elsevier North-Holland Biomedical Press)

    Google Scholar 

  8. Breimer, D. D. (1976). Pharmacokinetics of butobarbital after single and multiple oral doses in man. Eur. J. Clin. Pharmacol., 10., 263

    Article  CAS  Google Scholar 

  9. Breimer, D. D. (1977). Clinical pharmacokinetics of hypnotics. Clin. Pharmacokinet., 2., 93

    Article  PubMed  CAS  Google Scholar 

  10. Breimer, D. D. and de Boer, A. G. (1975). Pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium in man after oral administration. Eur. J. Clin. Pharmacol.., 9., 169

    Article  PubMed  CAS  Google Scholar 

  11. Breimer, D. D., Bracht, H. and de Boer, A. G. (1977). Plasma level profile of nitrazepam following oral administration. Br. J. Clin. Pharmacol., 4., 709

    CAS  Google Scholar 

  12. Breimer, D. D., de Boer, A. G., Bracht, H. and Pas, J. (1978). Comparative bioavailability investigation on some nitrazepam-containing pharmaceutical preparations available on the Dutch market. (In preparation)

    Google Scholar 

  13. Cano, J. P., Soliva, M., Hartmann, D., Ziegler, W. H. and Amrein, R. (1977). Bioavailability of various galenic formulation of flunitrazepam. Arzneim. Forsch., 27., 2383

    CAS  Google Scholar 

  14. De Boer, A. G., Rost-Kaiser, J., Bracht, H. and Breimer, D. D. (1978). Assay of underivatized nitrazepam and clonazepam in plasma by capillary gas chromatography applied to pharmacokinetic and bioavailability studies in humans. J. Chromatogr. Biomed. Appl., 245., 105

    Google Scholar 

  15. Eberts, F. S., Ko, H. and Thomas, R. C. (1978). Metabolism and pharmacokinetics of triazolam. (In preparation)

    Google Scholar 

  16. Fucella, L. M., Bolcioni, G., Tamassia, V., Ferrario, L. and Tognoni, G. (1977). Human pharmacokinetics and bioavailability of temazepam administered in soft gelatin capsules. Eur. J. Clin. Pharmacol., 12., 383

    Article  Google Scholar 

  17. Greenblatt, D. J., Joyce, T. H., Comer, W. H., Knowles, J. A., Shader, R. I., Kyriakopoulos, A. A., MacLaughlin, D. S. and Ruelius, H. W. (1977). Clinical pharmacokinetics of lorazepam. II. Intramuscular injection. Clin. Pharmacol. Ther., 21., 222

    PubMed  CAS  Google Scholar 

  18. Kales, A. and Scharf, M. B. (1973). Sleep laboratory and clinical studies of the effects of benzodiazepines on sleep: flurazepam, diazepam, chlordiazepoxide and RO 5–4200. In Garrattini, Mussini and Randall (eds.), The Benzodiazepines., pp. 577–598. (New York: Raven Press)

    Google Scholar 

  19. Kales, A., Bixler, E. O., Scharf, M. and Kales, J. D. (1976). Sleep laboratory studies of flurazepam: a model for evaluating hypnotic drugs. Clin. Pharmacol. Ther., 19., 576

    PubMed  CAS  Google Scholar 

  20. Kangas, L. (1977). Comparison of two gas-liquid chromatographic methods for the determination of nitrazepam in plasma. J. Chromatogr., 136., 259

    Article  PubMed  CAS  Google Scholar 

  21. Kangas, L., Iisalo, E., Kanto, J., Lehtinen, V., Pynnönen, S., Ruikka, I., Salminen, J., Sillanpää, M. and Syvälahti, E. (1978). Human pharmacokinetics of nitrazepam: effect of age and diseases. Eur. J. Clin. Pharmacol. (In press)

    Google Scholar 

  22. Kangas, L., Kanto, J. and Syvälahti, E. (1977). Plasma nitrazepam concentrations after an acute intake and their correlation to sedation and serum growth hormone levels. Acta Pharmacol. Toxicol., 41., 74

    Article  CAS  Google Scholar 

  23. Kaplan, S. A., de Silva, J. A. F., Jack, M. L., Alexander, K., Strojny, N., Weinfeld, R. E., Puglisi, C. V. and Weissman, L. (1973). Blood level profile in man following chronic oral administration of flurazepam hydrochloride. J. Pharm. Sci., 62., 1932

    Article  PubMed  CAS  Google Scholar 

  24. Klotz, U., Avant, G. R., Hayumpa, A., Schenker, S. and Wilkinson, G. R. (1975). The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J. Clin. Invest., 55., 347

    Article  PubMed  CAS  Google Scholar 

  25. Kortilla, K. and Kangas, L. (1977). Unchanged protein binding and the increase of serum diazepam levels after food intake. Acta Pharmacol. Toxicol., 40., 241

    Article  Google Scholar 

  26. Mark, L. C. (1969). Archaic classification of barbiturates. Clin. Pharmacol. Ther., 10., 287

    PubMed  CAS  Google Scholar 

  27. Nicholson, A. N. and Stone, B. M. (1976). Effect of a metabolite of diazepam, 3-hydroxydiazepam (temazepam), on sleep in man. Br. J. Clin. Pharmacol., 3., 543

    PubMed  CAS  Google Scholar 

  28. Nicholson, A. N. and Stone, B. M. (1977). Effectiveness of diazepam and its metabolite, 3-hydroxydiazepam (temazepam), for sleep during the day. J. Physiol., 270., 29P

    Google Scholar 

  29. Post, C., Lindgren, S., Bertler, A. and Malmgren, H. (1977). Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate. Psychopharmacolo gy., 53., 105

    Article  CAS  Google Scholar 

  30. Randall, L. O. and Kappell, B. (1973). Pharmacological activity of some benzodiazepines and their metabolites. In Garrattini, Mussini and Randall (eds.), The Benzodiazepines., pp. 27–51. (New York: Raven Press)

    Google Scholar 

  31. Rieder, J. (1973). Plasma levels and derived pharmacokinetic characteristics of unchanged nitrazepam in man. Arzneim. Forsch., 23., 212

    CAS  Google Scholar 

  32. Sjöqvist, F. and Sundwall, A. (eds.) (1977). The pharmacokinetic profile of oxazepam. Acta Pharmacol. Toxicol., 40. (Suppl.), I

    Google Scholar 

  33. Van Rossum, J. M. (1973). Pharmacokinetics and psychopharmacological research. Psychiatr. Neurol. Neurochir. (Amst.)., 76., 217

    Google Scholar 

  34. Wendt, G. (1976). Schichsal des Hypnotikums Flunitrazepam in menschlichen Organismus. In Hügin, Hossli, and Gemperle eds.). Bisherige Erfahrungen mit ‘Rohypnol’ (Flunitrazepam) in der Anästhesiologie und Intensivtherapie., pp. 27–38. (Basle: Editiones Roche)

    Google Scholar 

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Breimer, D.D. (1979). Clinical Pharmacokinetic and Biopharmaceutical Aspects of Hypnotic Drug Therapy. In: Priest, R.G., Pletscher, A., Ward, J. (eds) Sleep Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6226-5_6

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  • DOI: https://doi.org/10.1007/978-94-011-6226-5_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6228-9

  • Online ISBN: 978-94-011-6226-5

  • eBook Packages: Springer Book Archive

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