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Mechanisms of gastrointestinal ulceration from non-steroidal anti-inflammatory drugs: a basis for use and development of protective agents

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Side-Effects of Anti-Inflammatory Drugs 3

Part of the book series: Inflammation and Drug Therapy Series ((IDTH,volume 5))

Abstract

The past decade or so has seen an upsurge in interest on the clinical importance of gastrointestinal (GI) ulceration as a major side-effect of the non-steroidal anti-inflammatory drugs (NSAIDs) and with this research on the mechanisms thereof has also increased. A number of reviews on the clinical importance of GI side-effects from NSAIDs have been published [1–6]. The epidemiological evidence suggests that there is an appreciable risk of NSAID gastropathy in rheumatic patients [3,4], the risk being much greater in the elderly female patient [5].

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Authors and Affiliations

  1. Departments of Biomedical Sciences and Pathology, McMaster University Faculty of Health Sciences, Hamilton, L8N 3Z5, Ontario, Canada

    K. D. Rainsford

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  1. K. D. Rainsford
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Editors and Affiliations

  1. Department of Biomedical Sciences and Pathology, McMaster University Faculty of Health Sciences, Hamilton, L8N 3Z5, Ontario, Canada

    K. D. Rainsford

  2. Istituto of Farmacologia, Università di Verona, Policlinico Borgo Roma, Verona, 37134, Italy

    G. P. Velo

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© 1992 Springer Science+Business Media Dordrecht

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Rainsford, K.D. (1992). Mechanisms of gastrointestinal ulceration from non-steroidal anti-inflammatory drugs: a basis for use and development of protective agents. In: Rainsford, K.D., Velo, G.P. (eds) Side-Effects of Anti-Inflammatory Drugs 3. Inflammation and Drug Therapy Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2982-4_14

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  • DOI: https://doi.org/10.1007/978-94-011-2982-4_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5325-9

  • Online ISBN: 978-94-011-2982-4

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