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Summary of Evidence for an Anticodonic Basis for the Origin of the Genetic Code

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Origin of Life

Abstract

This article summarizes the data available from our own laboratory and others supporting the hypothesis that the genetic code origin was based on relationships (probably affinities) between amino acids and their anticodon nucleotides. Selective activation seems to follow from selective affinity and consequently, incorporation of amino acids into peptides can also be selective. We believe that these selectivities in affinity and activation, coupled with the base pairing specificities, allowed the origin of the code and the process of translation.

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Author information

Authors and Affiliations

  1. Laboratory of Molecular Biology, University of Alabama in Birmingham, University Station, Birmingham, Alabama, 35294, USA

    James C. Lacey Jr. & Dail W. Mullins Jr.

Authors
  1. James C. Lacey Jr.
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  2. Dail W. Mullins Jr.
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Editor information

Editors and Affiliations

  1. Department of Organic Chemistry, The Hebrew University, Jerusalem, Israel

    Yecheskel Wolman

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© 1981 D. Reidel Publishing Company

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Lacey, J.C., Mullins, D.W. (1981). Summary of Evidence for an Anticodonic Basis for the Origin of the Genetic Code. In: Wolman, Y. (eds) Origin of Life. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8420-2_59

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  • DOI: https://doi.org/10.1007/978-94-009-8420-2_59

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8422-6

  • Online ISBN: 978-94-009-8420-2

  • eBook Packages: Springer Book Archive

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