Summary
The data here show direct correlations between both the hydrophobicity and the hydrophilicity of the homocodonic amino acids and their anticodon nucleotides. While the differences between properties of uracil and cytosine derivatives are small, further data show that uracil has an affinity for charged species. Although these data suggest that molecular relationships between amino acids and anticodons were responsible for the origin of the code, it is not clear what the mechanism of the origin might have been.
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Weber, A.L., Lacey, J.C. Genetic code correlations: Amino acids and their anticodon nucleotides. J Mol Evol 11, 199–210 (1978). https://doi.org/10.1007/BF01734481
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DOI: https://doi.org/10.1007/BF01734481