Abstract
Daunorubicin and doxorubicin (or adriamycin) are among the most important of our current cancer chemotherapeutic drugs. They are key components in current therapy of acute leukemia, malignant lymphoma, breast cancer, thyroid cancer, and a variety of sarcomas. Although they are valuable therapeutic tools, they do have limitations and liabilities that have stimulated intense efforts to obtain analogues having a broader therapeutic spectrum and reduced toxicity; in particular, there is a desire to acquire drugs with a lessened cardiac toxicity. A remarkable number of analogues with diverse structural variations on the anthracycline theme have been isolated or synthesized. A smaller number of these have entered into clinical trial. This communication will examine studies at the Memorial Sloan-Kettering Cancer Center and summarize the current status of Phase II and clinical pharmacologic evaluation of 4′-epi-doxorubicin, Phase I and Phase II evaluation of aclacinomycin in leukemia, and the early results of our Phase I trial of 4-demethoxy-daunorubicin.
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© 1982 Martinus Nijhoff Publishers, The Hague
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Young, C.W., Wittes, R., Deesen, P., Jones, B., Casper, E., Warrell, R. (1982). Clinical Studies of New Anthracycline Analogs. In: Muggia, F.M., Young, C.W., Carter, S.K. (eds) Anthracycline Antibiotics in Cancer Therapy. Developments in Oncology, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7630-6_46
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DOI: https://doi.org/10.1007/978-94-009-7630-6_46
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