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Cell Fusion, Drug Resistance and Recurrence CSCs

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Cell Fusion in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 950))

Abstract

Cancer stem cells (CSCs) are a rare population of cancer cells exhibiting stem cell properties, such as self-renewal, differentiation and tissue restoration. Beside the initiation of the primary tumor, CSCs have also been associated with metastasis formation and cancer relapses. In the context of cancer relapses, we have recently postulated the existence of so-called recurrence CSCs (rCSCs). These specific CSC subtype will initiate relapses exhibiting an “oncogenic resistance” phenotype, which are characterized by a markedly increased malignancy concomitant with a drug resistance towards first line therapy. In the present chapter we will discuss the necessity of rCSCs as a distinct CSC subtype and that cell fusion could be one mechanism how rCSCs could originate.

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Acknowledgments

This work was supported by the “Verein zur Förderung der Krebsforschung e.V.”, Heidelberg, Germany and the Fritz-Bender-Foundation, Munich, Germany.

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Authors and Affiliations

  1. Institute of Immunology, Witten/Herdecke University, 58448, Witten, Germany

    Christa Nagler, Kurt S. Zänker & Thomas Dittmar

  2. Zentrum für Biomedizinische Ausbildung und Forschung an der UWH (ZBAF), Witten/Herdecke University, Institute of Immunology, 58448, Witten, Germany

    Thomas Dittmar

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  1. Christa Nagler
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  2. Kurt S. Zänker
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  3. Thomas Dittmar
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Correspondence to Thomas Dittmar .

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  1. Inst. Immunologie, Universität Witten/Herdecke, Stockumer Str. 10, Witten, 58448, Germany

    Thomas Dittmar

  2. Institute of Immunologie, University of Witten/Herdecke, Stockumer Str. 10, Witten, 58448, Germany

    Kurt S. Zänker

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Nagler, C., Zänker, K.S., Dittmar, T. (2011). Cell Fusion, Drug Resistance and Recurrence CSCs. In: Dittmar, T., Zänker, K. (eds) Cell Fusion in Health and Disease. Advances in Experimental Medicine and Biology, vol 950. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0782-5_9

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