Abstract
In the normal human body pancreatic β-cells spend most of the time in a READY mode rather than in an OFF mode. When in the READY mode, normal β-cells can be easily SWITCHED ON by a variety of apparently trivial stimuli. In the READY mode β-cells are highly excitable because of their high input resistance. A variety of small depolarizing currents mediated through a variety of cation channels triggered by a variety of chemical and physical stimuli can SWITCH ON the cells. Several polymodal ion channels belonging to the transient receptor potential (TRP) family may mediate the depolarizing currents necessary to shift the β-cells from the READY mode to the ON mode. Thanks to the TRP channels, we now know that the Ca2+-activated monovalent cation selective channel described by Sturgess et al. in 1986 (FEBS Lett 208:397–400) is TRPM4, and that the H2O2-activate non-selective cation channel described by Herson and Ashford, in 1997 (J Physiol 501:59–66) is TRPM2. Glucose metabolism generates heat which appears to be a second messenger sensed by the temperature-sensitive TRP channels like the TRPM2 channel. Global knock-out of TRPM5 channel impairs insulin secretion in mice. Other TRPs that may be involved in the regulation of β-cell function include TRPC1, TRPC4, TRPM3, TRPV2 and TRPV4. Future research needs to be intensified to study the molecular regulation of the TRP channels of islets, and to elucidate their roles in the regulation of human β-cell function, in the context of pathogenesis of human islet failure.
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References
Newsholme P, Gaudel C, McClenaghan NH (2010) Nutrient regulation of insulin secretion and beta-cell functional integrity. Adv Exp Med Biol 654:91–114
Islam MS (2010) Calcium signaling in the islets. Adv Exp Med Biol 654:235–259
Drews G, Krippeit-Drews P, Dufer M (2010) Electrophysiology of islet cells. Adv Exp Med Biol 654:115–163
Clark R, Proks P (2010) ATP-sensitive potassium channels in health and disease. Adv Exp Med Biol 654:165–192
Sakura H, Ashcroft FM (1997) Identification of four trp1 gene variants murine pancreatic beta-cells. Diabetologia 40:528–532
Roe MW, Worley JF III, Qian F, Tamarina N, Mittal AA, Dralyuk F, Blair NT, Mertz RJ, Philipson LH, Dukes ID (1998) Characterization of a Ca2+ release-activated nonselective cation current regulating membrane potential and [Ca2+]i oscillations in transgenically derived beta-cells. J BiolChem 273:10402–10410
Li F, Zhang ZM (2009) Comparative identification of Ca2+ channel expression in INS-1 and rat pancreatic beta cells. World J Gastroenterol 15:3046–3050
Qian F, Huang P, Ma L, Kuznetsov A, Tamarina N, Philipson LH (2002) TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells. Diabetes 51:S183–S189
Bari MR, Akbar S, Eweida M, Kuhn FJ, Gustafsson AJ, Lückhoff A, Islam MS (2009) H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels. J Cell Mol Med 13:3260–3267
Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y (2002) LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163–173
Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M (2006) TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J 25:1804–1815
Inamura K, Sano Y, Mochizuki S, Yokoi H, Miyake A, Nozawa K, Kitada C, Matsushime H, Furuichi K (2003) Response to ADP-Ribose by Activation of TRPM2 in the CRI-G1 Insulinoma Cell Line. J Membr Biol 191:201–207
Du J, Xie J, Yue L (2009) Intracellular calcium activates TRPM2 and its alternative spliced isoforms. Proc Natl Acad Sci USA 106:7239–7244
Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig A, Penner R (2009) TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal 2:ra23
Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, Dufer M, Lis A, Flockerzi V, Philipp SE, Oberwinkler J (2008) Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol 10:1421–1430
Cheng H, Beck A, Launay P, Gross SA, Stokes AJ, Kinet JP, Fleig A, Penner R (2007) TRPM4 controls insulin secretion in pancreatic beta-cells. Cell Calcium 41:51–61
Marigo V, Courville K, Hsu WH, Feng JM, Cheng H (2009) TRPM4 impacts on Ca2+ signals during agonist-induced insulin secretion in pancreatic beta-cells. Mol Cell Endocrinol 299:194–203
Prawitt D, Monteilh-Zoller MK, Brixel L, Spangenberg C, Zabel B, Fleig A, Penner R (2003) TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i. Proc Natl Acad Sci USA 100:15166–15171
Colsoul B, Schraenen A, Lemaire K, Quintens R, Van Lommel L, Segal A, Owsianik G, Talavera K, Voets T, Margolskee RF, Kokrashvili Z, Gilon P, Nilius B, Schuit FC, Vennekens R (2010) Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5–/– mice. Proc Natl Acad Sci USA 107:5208–5213
Akiba Y, Kato S, Katsube KI, Nakamura M, Takeuchi K, Ishii H, Hibi T (2004) Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats. Biochem Biophys Res Commun 321:219–225
Hisanaga E, Nagasawa M, Ueki K, Kulkarni RN, Mori M, Kojima I (2009) Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes 58:174–184
Casas S, Novials A, Reimann F, Gomis R, Gribble FM (2008) Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. Diabetologia 51:2252–2262
Holz GG, Leech CA, Habener JF (1995) Activation of a cAMP-regulated Ca2+-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1. J BiolChem 270:17749–17757
Leech CA, Habener JF (1998) A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells. Diabetes 47:1066–1073
Sturgess NC, Hales CN, Ashford ML (1986) Inhibition of a calcium-activated, non-selective cation channel, in a rat insulinoma cell line, by adenine derivatives. FEBS Lett 208: 397–400
Nilius B, Prenen J, Voets T, Droogmans G (2004) Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b. Pflugers Arch 448:70–75
Nilius B, Mahieu F, Karashima Y, Voets T (2007) Regulation of TRP channels: a voltage-lipid connection. Biochem Soc Trans 35:105–108
Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M (2007) Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol 8:312–320
Demion M, Bois P, Launay P, Guinamard R (2007) TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells. Cardiovasc Res 73:531–538
Sturgess NC, Kozlowski RZ, Carrington CA, Hales CN, Ashford ML (1988) Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line. Br J Pharmacol 95:83–94
Nilius B, Prenen J, Tang J, Wang C, Owsianik G, Janssens A, Voets T, Zhu MX (2005) Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem 280:6423–6433
Biden TJ, Schmitz-Peiffer C, Burchfield JG, Gurisik E, Cantley J, Mitchell CJ, Carpenter L (2008) The diverse roles of protein kinase C in pancreatic beta-cell function. Biochem Soc Trans 36:916–919
Nilius B, Mahieu F, Prenen J, Janssens A, Owsianik G, Vennekens R, Voets T (2006) The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J 25:467–478
Thore S, Wuttke A, Tengholm A (2007) Rapid turnover of phosphatidylinositol-4,5-bisphosphate in insulin-secreting cells mediated by Ca2+ and the ATP-to-ADP ratio. Diabetes 56:818–826
Fonfria E, Murdock PR, Cusdin FS, Benham CD, Kelsell RE, McNulty S (2006) Tissue distribution profiles of the human TRPM cation channel family. J Recept Signal Transduct Res 26:159–178
Liu D, Liman ER (2003) Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc Natl Acad Sci USA 100:15160–15165
Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, Lohse MJ, Shigemura N, Ninomiya Y, Kojima I (2009) Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One 4:e5106
Ullrich ND, Voets T, Prenen J, Vennekens R, Talavera K, Droogmans G, Nilius B (2005) Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium 37:267–278
Kang G, Chepurny OG, Rindler MJ, Collis L, Chepurny Z, Li WH, Harbeck M, Roe MW, Holz GG (2005) A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells. J Physiol 566:173–188
Dyachok O, Gylfe E (2004) Ca2+-induced Ca2+ release via inositol 1,4,5-trisphosphate receptors is amplified by protein kinase A and triggers exocytosis in pancreatic beta-cells. J Biol Chem 279:45455–45461
Brixel LR, Monteilh-Zoller MK, Ingenbrandt CS, Fleig A, Penner R, Enklaar T, Zabel BU, Prawitt D (2010) TRPM5 regulates glucose-stimulated insulin secretion. Pflugers Arch 460:69–76
Hofmann T, Chubanov V, Gudermann T, Montell C (2003) TRPM5 is a voltage-modulated and Ca2+-activated monovalent selective cation channel. Curr Biol 13:1153–1158
Wolf BA, Turk J, Sherman WR, McDaniel ML (1986) Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets. J BiolChem 261:3501–3511
Oike H, Wakamori M, Mori Y, Nakanishi H, Taguchi R, Misaka T, Matsumoto I, Abe K (2006) Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells. Biochim Biophys Acta 1761:1078–1084
Miura Y, Matsui H (2003) Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na+]i associated with insulin secretion in pancreatic beta-cells. Am J Physiol Endocrinol Metab 285:E1001–E1009
Leech CA, Habener JF (1997) Insulinotropic glucagon-like peptide-1-mediated activation of non-selective cation currents in insulinoma cells is mimicked by maitotoxin. J BiolChem 272:17987–17993
Brereton HM, Chen J, Rychkov G, Harland ML, Barritt GJ (2001) Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells. Biochim Biophys Acta 1540:107–126
Sinkins WG, Estacion M, Prasad V, Goel M, Shull GE, Kunze DL, Schilling WP (2009) Maitotoxin converts the plasmalemmal Ca2+ pump into a Ca2+-permeable nonselective cation channel. Am J Physiol Cell Physiol 297:C1533–C1543
Reale V, Hales CN, Ashford ML (1994) The effects of pyridine nucleotides on the activity of a calcium-activated nonselective cation channel in the rat insulinoma cell line, CRI-G1. J Membr Biol 142:299–307
Herson PS, Ashford ML (1997) Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1. J Physiol 501(Pt 1):59–66
Eisfeld J, Luckhoff A (2007) TRPM2. Handb.Exp.Pharmacol 179:237–252
Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (2001) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411:595–599
Toth B, Csanady L (2010) Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel. J Biol Chem 285:30091–30102
Zhang W, Chu X, Tong Q, Cheung JY, Conrad K, Masker K, Miller BA (2003) A Novel TRPM2 Isoform Inhibits Calcium Influx and Susceptibility to Cell Death. J BiolChem 278:16222–16229
McHugh D, Flemming R, Xu SZ, Perraud AL, Beech DJ (2003) Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem 278:11002–11006
Csanady L, Torocsik B (2009) Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate. J Gen Physiol 133:189–203
Heiner I, Eisfeld J, Warnstedt M, Radukina N, Jungling E, Lückhoff A (2006) Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes. Biochem J 398:225–232
Leloup C, Tourrel-Cuzin C, Magnan C, Karaca M, Castel J, Carneiro L, Colombani AL, Ktorza A, Casteilla L, Penicaud L (2009) Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion. Diabetes 58:673–681
Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Reece JM, Deeney JT, Andersen ME, Corkey BE, Collins S (2007) Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes 56:1783–1791
Wehage E, Eisfeld J, Heiner I, Jungling E, Zitt C, Lückhoff A (2002) Activation of the Cation Channel Long Transient Receptor Potential Channel 2 (LTRPC2) by Hydrogen Peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J BiolChem 277:23150–23156
Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM (2005) Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J BiolChem 280:6138–6148
Lange I, Penner R, Fleig A, Beck A (2008) Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils. Cell Calcium 44:604–615
Kim BJ, Park KH, Yim CY, Takasawa S, Okamoto H, Im MJ, Kim UH (2008) Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets. Diabetes 57:868–878
Uchida K, Dezaki K, Dambindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M (2010) Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes doi: 10.2337/db10-0276
Romero JR, Germer S, Castonguay AJ, Barton NS, Martin M, Zee RY (2010) Gene variation of the transient receptor potential cation channel, subfamily M, member 2 (TRPM2) and type 2 diabetes mellitus: a case-control study. Clin Chim Acta 411:1437–1440
Kraft R, Grimm C, Frenzel H, Harteneck C (2006) Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol 148:264–273
Silva-Alves JM, Mares-Guia TR, Oliveira JS, Costa-Silva C, Bretz P, Araujo S, Ferreira E, Coimbra C, Sogayar MC, Reis R, Mares-Guia ML, Santoro MM (2008) Glucose-induced heat production, insulin secretion and lactate production in isolated Wistar rat pancreatic islets. Thermochim Acta 474:67–71
Ohta M, Nelson D, Nelson J, Meglasson MD, Erecinska M (1990) Oxygen and temperature dependence of stimulated insulin secretion in isolated rat islets of Langerhans. J Biol Chem 265:17525–17532
Fonfria E, Marshall ICB, Boyfield I, Skaper SD, Hughes JP, Owen DE, Zhang W, Miller BA, Benham CD, McNulty S (2005) Amyloid beta-peptide(1–42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. J Neurochem 95:715–723
De Vos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F (1995) Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest 96:2489–2495
Eizirik DL, Pipeleers DG, Ling Z, Welsh N, Hellerstrom C, Andersson A (1994) Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury. Proc Natl Acad Sci USA 91:9253–9256
Elsner M, Tiedge M, Lenzen S (2003) Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan. Diabetologia 46:1713–1714
Dong XP, Wang X, Xu H (2010) TRP channels of intracellular membranes. J Neurochem 113:313–328
Mirnikjoo B, Balasubramanian K, Schroit AJ (2009) Mobilization of lysosomal calcium regulates the externalization of phosphatidylserine during apoptosis. J Biol Chem 284:6918–6923
Scharenberg A (2009) TRPM2 and pancreatic beta cell responses to oxidative stress. Islets 1:165–166
Oberwinkler J, Lis A, Giehl KM, Flockerzi V, Philipp SE (2005) Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J Biol Chem 280:22540–22548
Grimm C, Kraft R, Sauerbruch S, Schultz G, Harteneck C (2003) Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem 278:21493–21501
Lee N, Chen J, Sun L, Wu S, Gray KR, Rich A, Huang M, Lin JH, Feder JN, Janovitz EB, Levesque PC, Blanar MA (2003) Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3). J Biol Chem 278:20890–20897
Grimm C, Kraft R, Schultz G, Harteneck C (2005) Activation of the melastatin-related cation channel TRPM3 [corrected] by D-erythro-sphingosine. Mol Pharmacol 67:798–805
Bicikova M, Klak J, Hill M, Zizka Z, Hampl R, Calda P (2002) Two neuroactive steroids in midpregnancy as measured in maternal and fetal sera and in amniotic fluid. Steroids 67: 399–402
Tagawa N, Tamanaka J, Fujinami A, Kobayashi Y, Takano T, Fukata S, Kuma K, Tada H, Amino N (2000) Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism. Clin Chem 46:523–528
Bicikova M, Tallova J, Hill M, Krausova Z, Hampl R (2000) Serum concentrations of some neuroactive steroids in women suffering from mixed anxiety-depressive disorder. Neurochem Res 25:1623–1627
de Peretti E, Forest MG, Loras B, Morel Y, David M, Francois R, Bertrand J (1986) Usefulness of plasma pregnenolone sulfate in testing pituitary-adrenal function in children. Acta Endocrinol Suppl (Copenh) 279:259–263
Wagner TF, Drews A, Loch S, Mohr F, Philipp SE, Lambert S, Oberwinkler J (2010) TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells. Pflugers Arch 460:755–765
Nilius B, Prenen J, Wissenbach U, Bodding M, Droogmans G (2001) Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells. Pflugers Arch 443:227–233
Becker D, Blase C, Bereiter-Hahn J, Jendrach M (2005) TRPV4 exhibits a functional role in cell-volume regulation. J Cell Sci 118:2435–2440
Phan MN, Leddy HA, Votta BJ, Kumar S, Levy DS, Lipshutz DB, Lee SH, Liedtke W, Guilak F (2009) Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum 60:3028–3037
Miley HE, Sheader EA, Brown PD, Best L (1997) Glucose-induced swelling in rat pancreatic beta-cells. J Physiol 504(Pt 1):191–198
Grapengiesser E, Gylfe E, Dansk H, Hellman B (2003) Stretch activation of Ca2+ transients in pancreatic beta cells by mobilization of intracellular stores. Pancreas 26:82–86
Watanabe H, Davis JB, Smart D, Jerman JC, Smith GD, Hayes P, Vriens J, Cairns W, Wissenbach U, Prenen J, Flockerzi V, Droogmans G, Benham CD, Nilius B (2002) Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J BiolChem 277:13569–13577
Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE (2006) Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem 281:29897–29904
Thorneloe KS, Sulpizio AC, Lin Z, Figueroa DJ, Clouse AK, McCafferty GP, Chendrimada TP, Lashinger ES, Gordon E, Evans L, Misajet BA, Demarini DJ, Nation JH, Casillas LN, Marquis RW, Votta BJ, Sheardown SA, Xu X, Brooks DP, Laping NJ, Westfall TD (2008) N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropa noyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamid e (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. J Pharmacol Exp Ther 326:432–442
Gram DX, Ahren B, Nagy I, Olsen UB, Brand CL, Sundler F, Tabanera R, Svendsen O, Carr RD, Santha P, Wierup N, Hansen AJ (2007) Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes. Eur J Neurosci 25:213–223
Razavi R, Chan Y, Afifiyan FN, Liu XJ, Wan X, Yantha J, Tsui H, Tang L, Tsai S, Santamaria P, Driver JP, Serreze D, Salter MW, Dosch HM (2006) TRPV1(+) Sensory Neurons Control beta Cell Stress and Islet Inflammation in Autoimmune Diabetes. Cell 127:1123–1135
Dyachok O, Gylfe E (2001) Store-operated influx of Ca2+ in pancreatic beta-cells exhibits graded dependence on the filling of the endoplasmic reticulum. J Cell Sci 114:2179–2186
Dehaven WI, Jones BF, Petranka JG, Smyth JT, Tomita T, Bird GS, Putney JW Jr (2009) TRPC channels function independently of STIM1 and Orai1. J Physiol 587:2275–2298
Goswami C, Islam MS (2010) Transient receptor potential channels: what is happening? Reflections in the wake of the 2009 TRP meeting, karolinska institutet, stockholm. Channels (Austin) 4:124–135
Parnas M, Katz B, Lev S, Tzarfaty V, Dadon D, Gordon-Shaag A, Metzner H, Yaka R, Minke B (2009) Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. J Neurosci 29:2371–2383
Acknowledgments
I would like to thank Romain Guinamard and Frank Kühn for useful discussions. I am grateful to Stockholm County Council, Forskningscentrum, Landes Bioscience, and Engelbrechts kliniken. Financial support was obtained from the Swedish Research Council
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Islam, M.S. (2011). TRP Channels of Islets. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_42
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