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ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 5 (ST3GAL5)

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Handbook of Glycosyltransferases and Related Genes

Abstract

ST3Gal5 (GM3 synthase) was identified as the primary sialyltransferase responsible for the biosynthesis of ganglio-series gangliosides (Ishii et al. 1998; Kono et al. 1998; Fukumoto et al. 1999; Kapitonov et al. 1999). Ganglioside GM3 serves as a common precursor for complex gangliosides such as the a- and b-series gangliosides (Fig. 61.1). In addition, it was recently demonstrated that ST3Gal5 catalyzes GM4 synthesis in vivo (Chisada et al. 2009). Gangliosides are believed to form membrane microdomains (lipid rafts) that, with cholesterol and sphingomyelin, function as platforms for effective signal transduction in the plasma membrane (Simons and Gerl 2010) and participate in the regulation of numerous cellular processes, such as proliferation, differentiation, and adhesion (Hakomori 2004).

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Authors and Affiliations

  1. Division of Glycopathology, Tohoku Pharmaceutical University, Institute of Molecular Biomembranes and Glycobiology, Sendai, Miyagi, Japan

    Dr. Jin-ichi Inokuchi

  2. Molecular Genetic Research Department of Chemistry and Biological Science, Aoyama Gakuin University, College of Science and Engineering, 252-5258, Sagamihara, Japan

    Dr. Satoshi Uemura

Authors
  1. Dr. Jin-ichi Inokuchi
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  2. Dr. Satoshi Uemura
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Corresponding author

Correspondence to Jin-ichi Inokuchi .

Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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Inokuchi, Ji., Uemura, S. (2014). ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 5 (ST3GAL5). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_61

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