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Influencing energy expenditure and substrate utilisation

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Pharmacotherapy of Obesity

Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

Most of the anti-obesity drugs used over the past 50 years, and one (sibutramine) of the two globally licensed for long-term use today have acted centrally. With the exception of sibutramine (and the possible further approval of rimonabant), however, all of these have been withdrawn due to concerns over toxicity or abuse potential, or their use is greatly restricted. This is one reason why pharmaceutical companies are seeking drugs that act peripherally to influence energy expenditure, substrate utilisation or both. Fortunately, studies on genetically modified mice are revealing many new targets that fall into these categories [1].

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Author information

Authors and Affiliations

  1. CVG I Bioscience, Astra Zeneca, Mereside, Alderley Park, Macclesfield, SK10 4TG, UK

    John C. Clapham

  2. Clore Laboratory, University of Buckingham, Buckingham, Bucks, MK18 1EG, UK

    Jonathan R. Arch

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  1. John C. Clapham
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  2. Jonathan R. Arch
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Editors and Affiliations

  1. Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool, L9 7AL, UK

    John P. H. Wilding

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© 2008 Birkhäuser Verlag/Switzerland

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Clapham, J.C., Arch, J.R. (2008). Influencing energy expenditure and substrate utilisation. In: Wilding, J.P.H. (eds) Pharmacotherapy of Obesity. Milestones in Drug Therapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7425-9_8

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