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The in vivo Metabolic Investigation of Brain Gliomas with Positron Emission Tomography

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Advances and Technical Standards in Neurosurgery

Part of the book series: Advances and Technical Standards in Neurosurgery ((NEUROSURGERY,volume 24))

Abstract

Despite the major contribution it provides to practical neurooncolgy, morphological imaging by CT-scanner or magnetic resonance imaging techniques (MRI) is not always able to give definite answers about the histology of the tumor, its prognosis, or to predict early the response to therapy. Stereotactic biopsy usually provides a histopathological diagnosis and sometimes allows a grading of anaplasia; but most often this information is relevant only for a limited area within the tumor. In addition, biopsies cannot be performed repeatedly during the clinical follow-up of the patient and they do not always afford an individual assessment of the evolution of the tumor nor of the presumed sensitivity to any eventual therapeutic intervention. On the other hand, it is obvious that parameters which are closely related to tumor growth are not readily identified by radiological or histological investigations since most are biochemical, pharmacological or genetic in nature. Positron emission tomography (PET) affords a simultaneous in vivo measurement of some of these parameters, both within the tumor and in the surrounding, presumably healthy, brain.

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Derlon, J.M. (1998). The in vivo Metabolic Investigation of Brain Gliomas with Positron Emission Tomography. In: Cohadon, F., et al. Advances and Technical Standards in Neurosurgery. Advances and Technical Standards in Neurosurgery, vol 24. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6504-1_2

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