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Air Pollution, Subclinical Inflammation and the Risk of Type 2 Diabetes

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Environmental Influences on the Immune System

Abstract

Air pollution represents an important environmental risk factor for a number of health conditions. Particulate matter and gaseous compounds increase the risk of chronic and acute respiratory diseases, cardiovascular disease and lung cancer. Additional studies indicate that long-term exposure to air pollutants also contributes to the development and progression of type 2 diabetes. As the most common metabolic disease, type 2 diabetes and its chronic complications are important determinants of morbidity and mortality worldwide.

This article aims to provide an overview of the currently available data on the relationship between air pollution and type 2 diabetes with specific focus on epidemiological studies. Inflammatory processes have been discussed as mechanisms that mediate this association. Therefore, we first discuss the role of subclinical inflammation in the pathogenesis of type 2 diabetes and subsequently the impact of air pollutants on the immune system. We conclude that despite accumulating evidence linking (i) air pollution and proinflammatory processes, (ii) air pollution and risk of type 2 diabetes and (iii) subclinical inflammation and type 2 diabetes, there is a surprising lack of studies addressing this complex relationship in prospective cohorts. Therefore, it is currently not possible to quantify which proportion of the risk of type 2 diabetes can be attributed to air pollution-related immune activation and to what extent the risk of type 2 diabetes can be reduced by reducing air pollution levels.

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Acknowledgements

This study was supported by research grants from the Deutsche Forschungsgemeinschaft (DFG; HE-4510/2-1, KR 1938/3-1, LU 691/4-1). This work was supported by the Ministry of Innovation, Science and Research of the State of North Rhine-Westphalia (MIWF NRW) and the German Federal Ministry of Health (BMG). This study was supported in part by a grant from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD e.V.). We thank Kirti Kaul (German Diabetes Center) for critically reading the manuscript and for helpful discussions.

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  1. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany

    Tom Teichert & Christian Herder

  2. German Center for Diabetes Research (DZD e.V.), Düsseldorf, Germany

    Tom Teichert & Christian Herder

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  1. Tom Teichert
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  1. University of Düsseldorf, IUF–Leibniz Res Inst for Env Med, Düsseldorf, Germany

    Charlotte Esser

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Teichert, T., Herder, C. (2016). Air Pollution, Subclinical Inflammation and the Risk of Type 2 Diabetes. In: Esser, C. (eds) Environmental Influences on the Immune System. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1890-0_11

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