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Physiology of the Developing Kidney: Potassium Homeostasis and Its Disorder

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Pediatric Nephrology

Abstract

Potassium is the most abundant intracellular cation. Approximately 98 % of the total body potassium content is located within cells, primarily muscle, where its concentration ranges from 100 to 150 mEq/l; the remaining 2 % resides in the extracellular fluid, where the potassium concentration is tightly regulated within a narrow range (3.5–5.0 mEq/l in the adult). The ratio of the intra- to extracellular potassium concentration determines, in large part, the resting membrane potential and is thus critical for normal function of electrically excitable cells, including nerve and muscle.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Lisa M. Satlin

  2. Great Ormond Street Hospital, Institute of Child Health, University College London, London, UK

    Detlef Bockenhauer

Authors
  1. Lisa M. Satlin
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  2. Detlef Bockenhauer
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Correspondence to Lisa M. Satlin .

Editor information

Editors and Affiliations

  1. Department of Pediatrics, Medical College of Wisconsin, Children’s Research Institute, Children’s Hospital, Health System of Wisconsin, Milwaukee, Wisconsin, USA

    Ellis D. Avner

  2. Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    William E. Harmon

  3. Service de Néphrologie Pédiatrique, Hôpital Necker-Enfants Malades, Université Paris-Descartes, Paris, France

    Patrick Niaudet

  4. Department of Pediatrics, Wakayama Medical University, Wakayama City, Japan

    Norishige Yoshikawa

  5. Division of Nephrology, Bambino Gesù Children’s Hospital – IRCCS, Rome, Italy

    Francesco Emma

  6. Division of Nephrology and Hypertension, The Heart Institute, Cincinnati Children’s Hospital Medical Center, College of Medicine, Cincinnati, Ohio, USA

    Stuart L. Goldstein

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Satlin, L.M., Bockenhauer, D. (2016). Physiology of the Developing Kidney: Potassium Homeostasis and Its Disorder. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein, S. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43596-0_7

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  • DOI: https://doi.org/10.1007/978-3-662-43596-0_7

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  • Online ISBN: 978-3-662-43596-0

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