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Psychotropic effects of testosterone

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Testosterone

Abstract

In the human male, testosterone is qualitatively and quantitatively the most potent androgen in circulation. Over 95% of the total plasma testosterone concentration is secreted by the Leydig cells of the testes, while the remaining testosterone is produced by the adrenals (Braunstein 1986). In women, the ovaries secret approximately 25% of plasma testosterone, while the remainder of circulating testosterone is obtained through peripheral conversion (Longcope 1986). In blood testosterone is bound to sex-hormone-binding globulin and only a small fraction (the unbound or free testosterone) is available to receptors and thus biologically active. In order to exert its effects testosterone needs to be converted in some target tissues into dihydrotestosterone. In others it works directly or through aromatization to estrogens.

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  1. Walter Hubert
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  1. Institute of Reproductive Medicine, University of Münster, Steinfurter Straße 107, D-4400, Münster, Federal Republic of Germany

    Eberhard Nieschlag  & Hermann M. Behre  & 

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Hubert, W. (1990). Psychotropic effects of testosterone. In: Nieschlag, E., Behre, H.M. (eds) Testosterone. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00814-0_3

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  • DOI: https://doi.org/10.1007/978-3-662-00814-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-00816-4

  • Online ISBN: 978-3-662-00814-0

  • eBook Packages: Springer Book Archive

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