Abstract
Foci of altered hepatocytes are not visible with the naked eye.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abmayr W, Demi E, Oesterle D, Gössner W (1983) Nuclear morphology in preneoplastic lesions of rat liver. Anal Quant Cytol 5: 275–284
Altmann H W (1978) Pathology of human liver tumors. In: Remmer H, Bolt HM, Bannasch P, Popper H (eds) Primary liver tumors. University Park, Baltimore, pp 53–51
Altmann HW, Osterland U (1961) Über cytoplasmatische Wirbelbildungen in den Leberzellen der Ratte bei chronischer Thioacetamidvergiftung. Beitr Path Anat 124: 1–18
Bannasch P (1968) The cytoplasm of hepatocytes during carcinogenesis. Recent Results Cancer Res 19:1–10
Bannasch P (1975) Die Cytologie der Hepatocarcinoge-nese. In: Altmann H W et al. (Hrsg) Handbuch der Allgemeinen Pathologie. VI/7. Springer, Berlin Heidelberg New York, pp 123–276
Bannasch P (1976) Cytology and cytogenesis of neoplastic (hyperplastic) hepatic nodules. Cancer Res 36: 2555–2562
Bannasch P (1983) Strain and species differences in the susceptibility to liver tumour induction. IARC Sci Publ 51:9–38
Bannasch P, Müller HA (1964) Lichtmikroskopische Untersuchungen über die Wirkung von N-Nitrosomor-pholin auf die Leber von Ratte und Maus. Arzneim Forsch 14: 805–814
Bannasch P, Mayer D, Hacker HJ (1980) Hepatocellular glycogenosis and hepatocarcinogenesis. Biochim Biophys Acta 605: 217–245
Bannasch P, Moore MA, Klimek F, Zerban H (1982) Biological markers of preneoplastic foci and neoplastic nodules in rodent liver. Toxicol Pathol 10:19–36
Bannasch P, Benner U, Hacker H (1984 a) Tigroid cell foci and their possible relation to hepatic tumors. In: van Bezooijen CFA (ed) Pharmacological, morphological and physiological aspects of liver aging. Eurage, Rijswijk, pp 195–204
Bannasch P, Hacker H, Klimek F, Mayer D (1984b) Hepatocellular glycogenosis and related pattern of enzymatic changes during hepatocarcinogenesis. Adv Enzyme Reguł 22:97–121
Bannasch P, Moore MA, Hacker HJ, Klimek F, Mayer D, Enzmann H, Zerban H (1985) Potential significance of phenotypic instability in focal and nodular liver lesions induced by hepatocarcinogens. In: Brunner H, Thaler H (eds) Hepatology 1983. Raven, New York, pp 191–209
Bruni C (1973) Distinctive cells similar to fetal hepatocytes associated with liver carcinogenesis by diethylnitrosa-mine. Electron microscopic study. JNCI 50: 1513–1528
Buchmann A, Kuhlmann WD, Schwarz M, Kunz HW, Wolf CR, Moll E, Friedberg T, Oesch F (1985) Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver. Carcinogenesis 6: 513–521
Burek JD (1978) Age-associated pathology. In: Pathology of aging rats. CRC, Boca Raton FL, chap 4, pp 58–68
Daoust R, Calamai R (1971) Hyperbasophilic foci as sites of neoplastic transformation in hepatic parenchyma. Cancer Res 31:1290–1296
Emmelot P, Scherer E (1980) The first relevant stage in rat liver carcinogenesis. A quantitative approach. Biochim Biophys Acta 605: 247–304
Farber E (1980) The sequential analysis of liver cancer induction. Biochim Biophys Acta 605:149–166
Fischer G, Ullrich D, Katz N, Bock WK, Schauer A (1983) Immunohistochemical and biochemical detection of uridine-diphosphate-glucuronyltransferase (UDP-GT) activity in putative preneoplastic liver foci. Virchows Arch (Cell Pathol) 42:193–200
Friedrich-Freksa H, Papadopulu G, Gössner W (1969) Histochemische Untersuchungen der Cancerogenese in der Rattenleber nach zeitlich begrenzter Verabfolgung von Diäthylnitrosamin. Z Krebsforsch 72: 240–253
Grundmann E, Sieburg H (1962) Die Histogenese und Cy-togenese des Lebercarcinoms der Ratte durch Diäthylnitrosamin im lichtmikroskopischen Bild. Beitr Path Anat 126: 57–90
Hacker HJ, Moore MA, Mayer D, Bannasch P (1982) Correlative histochemistry of some enzymes of carbohydrate metabolism in preneoplastic and neoplastic lesions in the rat liver. Carcinogenesis 3: 1265–1272
Hirota N, Williams GM (1982) Ultrastructural abnormalities in carcinogen-induced hepatocellular altered foci identified by resistance to iron accumulation. Cancer Res 42: 2298–2309
Irac, NRC (1980) Histological typing of liver tumors of the rat. JNCI 64:179–206
Kalengayi MMR, Desmet VJ (1975) Sequential histological and histochemical study of the rat liver during anatoxin B1-induced carcinogenesis. Cancer Res 35: 2845–2852
Karasaki S (1969) The fine structure of proliferating cells in preneoplastic rat livers during azo-dye carcinogenesis. J Cell Biol 40: 322–335
Kitagawa T (1971) Histochemical analysis of hyperplastic lesions and hepatomas of the liver of rats fed 2-fiuoren-ylacetamide. Gann 62: 207–216
Klimek F, Mayer D, Bannasch P (1984) Biochemical microanalysis of glycogen content and glucose-6-phos-phate dehydrogenase activity in focal lesions of the rat liver induced by N-nitrosomorpholine. Carcinogenesis 5:265–268
Kuhlmann WD, Krischan R, Kunz W, Guenthner TM, Oesch F (1981) Focal elevation of liver microsomal epoxide hydrolase in early preneoplastic stages and its behavior in the further course of hepatocarcinogenesis. Biochem Biophys Res Commun 98: 417–423
Kunz W, Schaude G, Schwarz M, Tennekes H (1982) Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications. In: Hecker E, Fusenig NE, Kunz W, Marks F, Thielmann HW (eds) Cocarcinogenesis and biological effects of tumour promoters, vol 7, Carcinogenesis — a comprehensive survey. Raven, New York, pp 111–125
Lowry OH, Passonneau JV (1972) A flexible system of enzymatic analysis. Academic, New York
Moore MA, Mayer D, Bannasch P (1982) The dose-dependence and sequential appearance of putative preneoplastic populations induced in the rat liver by stop experiments with N-nitrosomorpholine. Carcinogenesis 3:1429–1436
Moore MA, Hacker HJ, Bannasch P (1983) Phenotypic instability in focal and nodular lesions induced in a short term system in the rat liver. Carcinogenesis 4:595–603
Ogawa K, Medline A, Farber E (1979) Sequential analysis of hepatic carcinogenesis. A comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal, and regenerating liver. Lab Invest 41: 22–35
Opie EL (1946) Mobilization of basophile substance (ribonucleic acid) in the cytoplasm of liver cells with the production of tumors by butter yellow. J Exp Med 84: 91–106
Pitot HC, Sirica AE (1980) The stages of initiation and promotion in hepatocarcinogenesis. Biochim Biophys Acta 605:191–215
Porter KR, Bruni C (1959) An electron microscope study of the early effects of 3’-Me-DAB on rat liver cells. Cancer Res 19:997–1009
Rabes HM (1983) Development and growth of early preneoplastic lesions induced in the liver by chemical carcinogens. J Cancer Res Clin Oncol 106: 85–92
Rabes HM, Bücher Th, Hartmann A, Linke I, Dünnwalkd M (1982) Clonal growth of carcinogen-induced enzyme-deficient preneoplastic cell populations in mouse liver. Cancer Res 42: 3220–3227
Reznik-Schüller HM, Gregg M (1983) Sequential morphologic changes during methapyrilene-induced hepatocellular carcinogenesis in rats. JNCI 71:1021–1031
Romen W, Ross W, Bannasch P (1972) Cytomorpholo-gische und morphometrische Studien der Hepatocarci-nogenese. II. Die Reversibilität von Kerngrößenänderungen in der Nitrosomorpholin-vergifteten Rattenleber. Z Krebsforsch 77:134–140
Romen W, Bannasch P, Aziz A, Reuss W (1973) Karyoki-nese und Kernstruktur während der Hepatocarcinoge-nese. II. Die Feinstruktur des Zellkerns in Hepatozyten und Hepatomzellen der Nitrosomorpholin-vergifteten Rattenleber. Virchows Arch (Cell Pathol) 13:267–296
Schauer A, Kunze E (1968) Enzymhistochemische und autoradiographische Untersuchungen während der Can-cerisierung der Rattenleber mit Diäthylnitrosamin. Z Krebsforsch 70: 252–266
Schauer A, Kunze E (1976) Tumors of the liver. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol I, Tumours of the rat, part 2. IARC Sci Publ no 6, Lyon, pp 41–72
Scherer E, Emmelot P (1976) Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis. Cancer Res 36: 2544–2554
Scherer E, Hoffmann M (1971) Probable clonal genesis of cellular islands induced in rat liver by diethylnitros-amine. Eur J Cancer 7: 369–371
Schulte-Hermann R, Roome N, Timmermann-Trosiener I, Schuppler J (1984) Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P-450 in putative preneoplastic foci of rat liver. Carcinogenesis 5: 143–153
Solt D, Farber E (1976) New principle for the analysis of chemical carcinogenesis. Nature 263: 701–703
Squire RA, Levitt MH (1975) Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res 35: 3214–3223
Steiner JW, Miyai K, Phillips MJ (1964) Electron microscopy of membrane-particle arrays in liver cells of ethio-nine-intoxicated rats. Am J Pathol 44:169–213
Stenger RJ (1966) Concentric lamellar formations in hepatic parenchymal cells of carbon tetrachloride-treated rats. J Ultrastruct Res 14: 240–253
Taper HS, Bannasch P (1976) Histochemical correlation between glycogen, nucleic acids and nucleases in preneoplastic and neoplastic lesions of rat liver after short term administration of N-nitrosomorpholine. Z Krebsforsch 87: 53–65
Taper HS, Bannasch P (1979) Histochemical differences between so-called megalocytosis and neoplastic or preneoplastic liver lesions induced by N-nitrosomor-pholine. Eur J Cancer 15:189–196
Tatematsu M, Takano T, Hasegawa R, Imaida K, Nakanowatari J, Ito N (1980) A sequential quantitative study of the reversibility or irreversibility of liver hyperplastic nodules in rats exposed to hepatocarcinogens. Gann 71: 843–855
Theodossiou A, Bannasch P, Reuss R (1971) Glykogen und endoplasmatisches Retikulum der Leberzelle nach hohen Dosen des Carcinogens N-Nitrosomorpholin. Virchows Arch (Cell Pathol) 7:126–146
Ward JM (1981) Morphology of foci of altered hepatocytes and naturally-occurring hepatocellular tumors in F 344 rats. Virchows Arch (Pathol Anat) 390: 339–345
Weber G (1982) Differential carbohydrate metabolism in tumor and host. In: Arnott MS, Van Eys J, Wang Y-M (eds) Molecular interrelations of nutrition and cancer. Raven, New York, pp 191–208
Williams GM (1976) Functional markers and growth behaviour of preneoplastic hepatocytes. Cancer Res 36: 2540–2543
Williams GM (1980) The pathogenesis of rat liver cancer caused by chemical carcinogens. Biochim Biophys Acta 605:167–189
Williams GM, Watanabe K (1978) Quantitative kinetics of development of iV-2-fluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen. JNCI 61:113–121
Williams GM, Klaiber M, Parker SE, Farber E (1976) Nature of early appearing, carcinogen-induced liver lesions resistant to iron accumulation. JNCI 57:157–165
Willis RA (1967) Pathology of tumours. Butterworth, London
Wu PC, Lai CL, Lam KC, Lok ASF, Lin HJ (1983) Clear cell carcinoma of liver. An ultrastructural study. Cancer 52:504–507
Zerban H, Rabes H, Bannasch P (1985) Proliferation kinetics during hepatocarcinogenesis. Eur J Cancer (in press)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Bannasch, P., Zerban, H., Hacker, H.J. (1985). Foci of Altered Hepatocytes, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Digestive System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96910-2_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-96910-2_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-96912-6
Online ISBN: 978-3-642-96910-2
eBook Packages: Springer Book Archive