Skip to main content
SpringerLink
Log in

HLA Associations with Malaria in Africa: Some Implications for MHC Evolution

  • Conference paper
Molecular Evolution of the Major Histocompatibility Complex

Part of the book series: NATO ASI Series ((ASIH,volume 59))

Abstract

A recent large case-control study of malaria in West African children has demonstrated the first clear HLA associations with a fatal infectious disease of humans, supporting the theory that MHC polymorphism is pathogen driven. The time for the protective HLA alleles to rise in frequency as a result of natural selection by malaria, and the possible mechanisms of this selection, overdominant, frequency-dependent or fluctuating, are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bengtsson, B.O. and Thomson, G.: Measuring the strength of associations between HLA antigens and diseases. Tissue Antigens 18: 356–363, 1981

    Article  PubMed  CAS  Google Scholar 

  • Bjorkman, P.J. and Parham, P.: Structure, function and diversity of class I major histocompatibility complex molecules. Ann Rev Biochem 59: 253–288, 1990

    Article  PubMed  CAS  Google Scholar 

  • Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennet, W.S., Strominger, J.L., and Wiley, D.C.: The foreign antigen binding site and T cell recognition regions of class I major histocompatibility antigens. Nature 329: 512–518, 1987

    Article  PubMed  CAS  Google Scholar 

  • Briles, W.E., Stone, H.A., and Cole, R.K.: Marek’s disease: effects of B histocompatibility alloalleles in resistant and susceptible chickens. Science 195: 193–195, 1977

    Article  PubMed  CAS  Google Scholar 

  • Bruce-Chwatt, L.J. In W.H. Wernsdorfer and I.A. McGregor (eds.): Malaria: Principles and Practice of Malariology, pp. 1–59. Churchill-Livingstone, Edinburgh 1988

    Google Scholar 

  • Cavalli-Sforza, L.L. and Bodmer, W.F.: The Genetics of Human Populations, pp. 133–184. W.H. Freeman Co., San Francisco 1971

    Google Scholar 

  • Clarke, B. and Kirby, D.R.S.: Maintenance of histocompatibility polymorphisms. Nature 211: 999–1000, 1966

    Article  PubMed  CAS  Google Scholar 

  • Creasey, A., Fenton, B., Walker, A., Thaitong, S., Oliveira, S., Mutambu, S., and Walliker, D.: Genetic diversity of Plasmodium falciparum shows geographical variation. Am J Trop Med Parasitol 42: 403–413, 1990

    CAS  Google Scholar 

  • de Vries, R.R., Khan, P.M., Bernini., L.F, van Loghem, E., and van Rood, J.J.: Genetic control of survival in epidemics. J Immunogenet 6: 271–287, 1979

    Article  PubMed  Google Scholar 

  • de Vries, R.R., Schreuder, G.M.T., Naipal, A., D’Amaro, J., and van Rood, J.J.: Selection by typhoid and yellow fever epidemics witnessed by the HLA-DR locus. In B. Dupont (ed.): Immunobiology of HLA. Springer-Verlag, New York 1989

    Google Scholar 

  • Dempster, E.R.: Maintenance of genetic heterogeneity. Cold Spring Harbor Symp Quant Biol 20: 25–32, 1955

    PubMed  CAS  Google Scholar 

  • Denniston, C. and Crow, J.F.: Alternative fitness models with the same allele frequency dynamics. Genetics 125: 201–205

    Google Scholar 

  • Doherty, P.C. and Zinkernagel, R.M.: A biological role for the major histocompatibility antigens Lancet i: 1406–1409, 1975

    Article  Google Scholar 

  • Ferstl., R., Eggert, F., Pause, B. et al.: Immune system signalling to the others brain: MHC- specific body scents in humans. 6th International Symposium on Neuronal Control of Bodily Function: Basic and Clinical Aspects. Hogrisi, Toronto 1989

    Google Scholar 

  • Figueroa, F., Gunther E., and Klein, J.: MHC polymorphism pre-dating speciation. Nature 335: 265–267, 1988

    Article  PubMed  CAS  Google Scholar 

  • Flaherty, L.: Major histocompatibility complex polymorphism: a nonimmune theory for selection. Hum Immunol 21: 3–13, 1987

    Article  Google Scholar 

  • Gillespie, J.H.: The interaction of genetic drift and mutation with selection in a fluctuating environment. Theor Popul Biol 27: 222–237, 1985

    Article  PubMed  CAS  Google Scholar 

  • Gillespie, J.H.: A general model to account for enzyme variation in natural populations. V. The SAS-CFF model. Theor Popul Biol 14: 1–45, 1978

    Article  PubMed  CAS  Google Scholar 

  • Good, M.F., Berzofsky, J.A., and Miller, L.H.: The T cell response to the malaria circumsporozoite protein: an immunological approach to vaccine development. Ann Rev Immunol 6: 663–688, 1988

    Article  CAS  Google Scholar 

  • Greenwood, B.M., Marsh, K., and Snow, R.W.: Why do some African children develop severe malaria? Parasitol Today (in press 1991)

    Google Scholar 

  • Greenwood, B.M., Bradley, A.K., Greenwood, A.M., Byass, P., Jammeh, K., Marsh, K., Tulloch, S., Oldfield, F.S., and Hayes, R.: Mortality and morbidity from malaria among children in a rural area of The Gambia, West Africa. Trans Roy Soc Trop Med Hyg 81: 478–486, 1987

    Article  PubMed  CAS  Google Scholar 

  • Haldane, J.B.S. and Jayakar, S.D.: Polymorphism due to selection of varying direction. J Genet 58: 237–242, 1963

    Article  Google Scholar 

  • Hamilton, W.D., Henderson, P.A., and Moran N.A.: Fluctuation of environment and coevolved antagonist polymorphism as factors in the maintenance of sex. In R.D. Alexander and D.W. Tinkle (eds.): Natural Selection and Social Behaviour: Recent Research and Theory, pp 363–381. Chiron, New York 1981

    Google Scholar 

  • Hamilton, W.D., Axelrod, R., and Tanese, R.: Sexual reproduction as an adaotation to resist parasites. Proc Natl Acad Sci USA 87: 3566–3573, 1990

    Article  PubMed  CAS  Google Scholar 

  • Hedrick, P.W.: Genetic variation in a heterogeneous environment. I. Temporal heterogeneity and the absolute dominance model. Genetics 78: 757–770, 1974

    PubMed  CAS  Google Scholar 

  • Hedrick, P.W. and Thomson, G.: Maternal-fetal interactions and the maintenance of HLA polymorphism. Genetics 119: 205–212, 1988

    PubMed  CAS  Google Scholar 

  • Hill, A.V.S., Allsopp, C.E.M., Kwiatkowski, D., Anstey, N.M., Twumasi, P., Rowe, P.A., Bennett, S., Brewster, D., McMichael, A.J., and Greenwood, B.M.: Common West African HLA antigens are associated with protection from severe malaria. Nature (in press 1991)

    Google Scholar 

  • Hughes, A.L. and Nei, M.: Pattern of nucleotide substitution at major histocompatibility class I loci reveals overdominant selection. Nature 335: 167–170, 1988

    Article  PubMed  CAS  Google Scholar 

  • Karlin, S. and Campbell, R.B.: The existence of a protected polymorphism under conditions of soft as opposed to hard selection in a multi-deme population system. Am Nat 117: 262–275, 1981

    Article  Google Scholar 

  • Karlin, S. and Lieberman, U.: Temporal fluctuations in selection intensities: case of large population size. Theor Popul Biol 6: 355–382, 1974

    Article  PubMed  CAS  Google Scholar 

  • Klein, J.: Origin of major histocompatibility complex polymorphism: the trans-species hypothesis Hum Immunol 19: 155–162, 1987

    Article  PubMed  CAS  Google Scholar 

  • Lawlor, D.A., Ward, F.E., Ennis, P.D., Jackson, A.P., and Parham, P.: HLA-A, and B polymorphism predate the divergence of humans and chimpanzees. Nature 335: 68–271, 1988

    Article  Google Scholar 

  • Marsh, K. and Greenwood, B.M.: The immunopathology of malaria. Clinics Trop Med Comm Dis 1: 91–125, 1986

    Google Scholar 

  • Nei, M.: Molecular Evolutionary Genetics, pp. 335–339. Columbia University Press, New York 1987

    Google Scholar 

  • Serjeantson, S.W.: The reasons for MHC polymorphism in man. Transplant Proc 21: 598–601, 1989

    PubMed  CAS  Google Scholar 

  • Snell, G.D.: The H-2 locus of the mouse: observations, and speculations concerning its comparative genetics, and its polymorphism. Folia Biol 14: 335–358, 1968

    CAS  Google Scholar 

  • Takahata, N. and Nei, M.: Alleleic genealogy under overdominant, and frequency-dependent selection, and polymorphism of the major histocompatibility complex. Genetics 124: 967–978, 1990

    PubMed  CAS  Google Scholar 

  • Takahata, N.: Genetic variability, and rate of gene substitution in a finite population under mutation, and fluctuating selection. Genetics 98: 427–440, 1981

    PubMed  CAS  Google Scholar 

  • Wills, C.: Rank order selection is capable of maintaining all genetic polymorphism. Genetics 89: 403–417, 1978

    PubMed  CAS  Google Scholar 

  • Yamazaki, K., Boyse, E.A., Mike, V., Thaler, H.T., Mathieson, B.J., Abbott, J., Boyse, J., Zayas, Z.A., and Thomas, L.: Control of mating preferences in mice by genes in the major histocompatibility complex. J Exp Med 144: 1324–1335, 1976

    Article  PubMed  CAS  Google Scholar 

  • Zavazava, N., Westphal, E., and Mueller-Ruchholtz, W.: Characterization of soluble HLA molecules in sweat and quantitative HLA differences in serum of healthy individuals. J Immunogenet 17: 387–394, 1990

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    Adrian V. S. Hill

Authors
  1. Adrian V. S. Hill
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abt. Immungenetik, Max-Planck-Institut für Biologie, Corrensstr. 42, W-7400, Tübingen, Germany

    Jan Klein

  2. Dept. of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida, USA

    Dagmar Klein

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Hill, A.V.S. (1991). HLA Associations with Malaria in Africa: Some Implications for MHC Evolution. In: Klein, J., Klein, D. (eds) Molecular Evolution of the Major Histocompatibility Complex. NATO ASI Series, vol 59. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84622-9_33

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84622-9_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84624-3

  • Online ISBN: 978-3-642-84622-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation