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Frozen Haplotypes in Mhc Evolution

  • Conference paper
Molecular Evolution of the Major Histocompatibility Complex

Part of the book series: NATO ASI Series ((ASIH,volume 59))

Abstract

An odd feature of the HLA-DRB region is its remarkable haplotype polymorphism: At least five groups of haplotypes differing both in length and in number of genes exist in the human population at appreciable frequencies. We have demonstrated that similar DRB haplotype polymorphism exists also in the apes - the chimpanzee and the gorilla. Moreover, certain haplotype segments have apparently remained intact since the human-chimpanzee (gorilla) divergence more than five million years ago. Hence, not only allelic but also haplotype polymorphisms evolve trans-specifically at the DRB region. The evolutionary origins of the individual haplotype groups and the possible reasons for the extreme linkage disequilibrium between certain DRB genes (the frozen haplotypes) are discussed.

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Authors and Affiliations

  1. Abteilung Immungenetik, Max-Planck-Institut für Biologie, 7400, Tübingen, Germany

    Jan Klein, Colm O’hUigin & Felipe Figueroa

  2. Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL, 33101, USA

    Jan Klein, Masanori Kasahara, Vladimir Vincek & Dagmar Klein

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  1. Jan Klein
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  2. Colm O’hUigin
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  3. Masanori Kasahara
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  4. Vladimir Vincek
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  5. Dagmar Klein
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  1. Abt. Immungenetik, Max-Planck-Institut für Biologie, Corrensstr. 42, W-7400, Tübingen, Germany

    Jan Klein

  2. Dept. of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida, USA

    Dagmar Klein

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Klein, J., O’hUigin, C., Kasahara, M., Vincek, V., Klein, D., Figueroa, F. (1991). Frozen Haplotypes in Mhc Evolution. In: Klein, J., Klein, D. (eds) Molecular Evolution of the Major Histocompatibility Complex. NATO ASI Series, vol 59. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84622-9_23

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  • DOI: https://doi.org/10.1007/978-3-642-84622-9_23

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