Abstract
At least two DRB loci are transcribed in the B lymphocytes of the cotton-top tamarin, Saguinus oedipus, a representative of the Platyrrhini (New World monkeys). One of the loci, Saoe-DRB1, is functional, the other (Saoe-DRB2) seems to be occupied by pseudogenes. The polymorphism of the genes at the functional DRB1 locus may be low. Neither of the two loci is directly orthologous to any of the known DRB genes thus far found in the Catarrhini. We suggest that the Platyrrhini were founded by a small number of animals and that the switch from one set of functional genes to another occurred as a result of genetic drift in the founding population.
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Grahovac, B., O’hUigin, C., Tichy, H., Mayer, W.E., Klein, J. (1991). Mhc Class II Genes of New World Monkeys and their Relationship to Human Genes. In: Klein, J., Klein, D. (eds) Molecular Evolution of the Major Histocompatibility Complex. NATO ASI Series, vol 59. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84622-9_17
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DOI: https://doi.org/10.1007/978-3-642-84622-9_17
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