Abstract
The effects of irradiation on the tissues of the eye and orbit have been studied intensively ever since Roentgen’s discovery of x-rays. Chalupecky (1897) investigated in animal experiments the effect of x-rays on the cells and tissues of the eye, especially the structures of the anterior segment. Birch-Hirschfeld (1904) demonstrated that the ocular tissues are highly radiosensitive. Amman (1906) was the first to report the development of radiation-induced cataract. Thereafter, numerous publications focused on the problem of radiation cataractogenesis. Other tissues such as the optic nerve and retina were studied to a lesser degree (Rubin and Casarett 1968).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abramson DH, Ellsworth RM, Zimmerman LE (1974) Nonocular cancer in radiotherapy for retinoblastoma. Am Surg 40: 485–490
Abramson DH, Ronner HJ, Ellsworth RM (1979) Second tumors in nonirradiated bilateral retinoblastoma. Am J Ophthalmol 87: 624–627
Abramson Dh, Ellworth RM, Zimmerman LE (1976) Nonocular cancer in retinoblastoma survivors. Trans Am Acad Ophthal Otolaryng 87: 624–627
Abramson DH, Ellsworth RM, Rosenblatt M, Tretter P, Jereb B, Kitchin D (1982) Retreatment of retinoblastoma with external beam irradiation. Arch Ophthalmol 100: 1257–1260
Abramson DH, Ellsworth RM, Kitchin D, Tung G (1984) Second nonocular tumors in retinoblastoma survivors. Are they radiation-induced? Ophthalmology 91: 1351–1355
Alberti W, Halama J (1987) Tumoren des Auges und der Orbita. In: Scherer E (ed) Strahlentherapie, Radiologische Onkologie. Springer, Berlin Heidelberg New York, pp 412–467
Alberti W, Adametz KP, El-Hifnawi E, Bornfeld N, Foerster MH (1988) Preliminary results after hyperthermia of minipig eyes with and without external beam therapy. In: Sugahara T, Saito M (eds) Hyperthermic oncology, 1, 1988, summary papers. Taylor & Francis, London, pp 100–102
Amman E (1906) Zur Wirkung der Röntgenstrahlen auf das menschliche Auge. Korrespondenz-Blatt für Schweizer Ärzte 15
Aristizabal S, Caldwell WL, Avita J (1977) The relationship of time-dose fractionation factors of complications in the treatment of pituitary tumors by irradiation. Int J Radiat Oncol Biol Phys 2: 667–673
Augsburger JJ, Shields JA (1985) Cataract surgery following cobalt-60 plaque. Radiotherapy for posterior uveal malignant melanoma. Ophthalmology 92: 815–822
Bedford MA, Bedotto C, MacFaul PA (1970) Radiation retinopathy after the application of a cobalt plaque. Br J Ophthalmol 54: 505–509
Birch-Hirschfeld A (1904) Die Wirkung der Röntgen- und Radiumstrahlen auf das Auge. Graefes Arch Ophthalmol 59: 229–310
Blodi FC (1958) The late effects of x-radiation on the cornea. Trans Am Ophthalmol Soc 56: 413
Blodi FC (1960) The effects of experimental x-radiation on the cornea. Arch Ophthalmol 63: 44–53.
Brown CD, Cibis PA, Pickering JE (1955) Radiation studies on the monkey eyes. Arch Ophthalmol 59: 249–256
Brown GC, Shields JA, Sanborn G, Augsburger JJ, Savino PJ, Schatz NJ (1981) Radiation retinopathy. Ophthalmology 43: 144–151
Brown GC, Shields JA, Sanborn G, Augsburger JJ, Savino PJ, Schatz NJ (1982) Radiation optic neuropathy. Ophthalmology 89: 1489–1493
Cassady JR, Sagerman RH, Tretter P, Ellsworth RM (1969) Radiation therapy in retinoblastoma. Radiology 93: 405–409
Cavaggioni A, Peracchia G, Rosati G (1969) Electrical activity of the ganglion cells in irradiated retinas. Radiat Res 39: 658
Chalupecky H (1897) Über die Wirkung der Röntgenstrahlen auf das Auge und die Haut. Zentralbl Augen- heilkd 21: 234
Chan RC, Shukovsky LJ (1976) Effects of irradiation on the eye. Radiology 120: 673–675
Char DH, Lonn LI, Margolis LW (1977) Complications of cobalt plaque therapy of choroidal melanomas. Am J Ophthalmol 84: 536–540
Chaudhuri PR, Austin DJ, Rosenthal AR (1981) Treatment of radiation retinopathy. Br J Ophthalmol 65: 623–625
Chee PHY (1968) Radiation retinopathy. Am J Ophthalmol 66: 860
Cibis PA, Brown DVL (1955) Retinal changes following ionizing radiation. Am J Ophthalmol 40: 84–88
Cibis PA, Noell WK, Eichel B (1955) Ocular effects produced by high intensity x-radiation. Arch Ophthalmol 53: 651
Coleman DJ, Lizzi FL, Burgess SEP (1986) Ultrasonic hyperthermia and radiation in the management of intaocular malignant melanoma. Am J Ophthalmol 101: 635–642
Deeg HJ (1984) Bone marrow transplantation: a review of delayed complications. Br J Haematol 57: 185–208
De Schryver A, Wachtmeister L, Baryd I (1971) Ophthalmologic observations on long-term survivors after radiotherapy for nasopharyngeal tumours. Acta Radiol 10: 193–209
Dhir SP, Joshi AV, Banerjee AK (1982) Radiation retinopathy in diabetes mellitus. Acta Radiol Oncol 21: 111–113
Donegan J (1956) Ocular effects of body 60Co irradiation. Am J Ophthalmol 42: 309
Draper GJ, Sanders BM, Kingston JE (1986) Second primary neoplasms in patients with retinoblastoma. Br J Cancer 53: 661–671
Duke-Elder S (1972) System of ophthalmology, vol 14, part 2: Injuries; nonmechanical injuries. CV Mosby, St. Louis, 985–999
Egbert PR, Donaldson SS, Moazed K, Rosenthal R (1978) Visual results and ocular complications following radiotherapy for retinoblastoma. Arch Ophthalmol 96: 1826–1830
Egbert PR, Fajardo LF, Donaldson SS, Moazed K (1980) Posterior ocular abnormalities after irradiation for retinoblastoma: a histopathological study. Br J Ophthalmol 64: 660–665
Ellsworth RM (1969) The practical management of retinoblastoma. Trans Am Ophthalmol Soc 67: 462–534
Ellsworth RM (1977) Retinoblastoma. Mod Probl Ophthalmol 18: 94–199
Finger PT, Packer S, Svitra PP, Paglione RW, Chess J, Albert S (1984) Hyperthermic treatment of intraocular tumors. Arch Ophthalmol 102: 1477–1481
Finger PT, Packer S, Svitra PP, Paglione RW, Anderson LL, Kim JH, Jakobiec FA (1985) Thermoradiotherapy for intraocular tumors. Arch Ophthalmol 103: 1574–1578
Finger PT, Packer S, Svitra PP, Paglione RW, Gatz JF, Ho TK, Bosworth JL (1989) Thermoradiotherapy of choro- dial melanoma. Ophthalmology 96: 1384–1388
Fishman ML, Bean SC, Cogan DG (1976) Optic atrophy following prophylactic chemotherapy and cranial radiation for acute lymphocytic leukemia. Am J Ophthalmol 82: 571–576
Fitzgerald CR, Enoch JM, Temme LA (1981) Radiation therapy in and about the retina, optic nerve and anterior visual pathway; psychophysical assessment. Arch Ophthalmol 99: 611–623
Foerster MH, Bornfeld N, Schulz U, Wessing A, Meyer-Schwickerath G (1986) Complications of local beta radiation of uveal melanomas. Graefes Arch Clin Exp Ophthalmol 224: 336–340
Forrest AW (1961) Tumors following radiation about the eye. Trans Am Acad Ophthalmol Otolaryngol 65: 694
Ghatak NR, White BE (1969) Delayed radiation necrosis of the hypothalamus. Arch Neurol 21: 425–430
Gragoudas ES, Zakow NZ, Albert DM (1979) Long-term observations of proton-irradiation monkey eyes. Arch Ophthalmol 97: 2184–2191
Gragoudas ES, Seddon JM, Egan K et al. (1987) Longterm results of proton beam irradiated uvea melanomas. Ophthalmology 94: 349–353
Guy J, Schatz NJ (1986) Hyperbaric oxygen in the treatment of radiation induced optic neuropathy. Ophthalmology 93: 1083–1088
Haik BG, Jereb B, Smith ME, Ellsworth RM, McCormick B (1986) Radiation and chemotherapy of parameningeal rhabdomyosarcoma involving the orbit. Ophthalmology 93: 1001–1009
Harris JR, Levene MB (1976) Visual complications following irradiation for pituitary adenomas and craniopharyngiomas. Radiology 120: 167–171
Hartzier J, Neldner KH, Forstot L (1984) x-ray epilation for the treatment of trichiasis. Arch Dermatol 120: 620–624
Hayreh SS (1970) Post radiation therapy. A fluorescence fundus angiographic study. Br J Ophthalmol 54: 705–714
Heyn R, Ragab A, Raney B et al. (1986) Late effects of therapy in orbital rhabdomyosarcoma in children. Cancer 57: 1738–1743
Howard GM (1966) Ocular effects of radiation and photocoagulation. Arch Ophthalmol 76: 7
Irvine AR, Wood IS (1987) Radiation retinopathy as an experimental model for ischemic proliferative retinopathy and rubeosis iridis. Am J Ophthalmol 103: 790–797
Irvine AR, Alvarado JA, Wara WM, Morris BW, Wood IS (1981) Radiation retinopathy: an experimental model for the ischemic proliferative retinopathies. Trans Am Ophthalmol 79: 103–122
Jensen RD, Miller RW (1971) Retinoblastoma: epidemiology characteristics. N Engl J Med 285: 307–311
Kinyoun JL, Kalina RE, Brower SA, Mills RP, Johnson RH (1984) Radiation retinopathy after orbital irradiation for Graves’ ophthalmopathy. Arch Ophthalmol 102:1473–1476
Kline LB, Kim JY, Cebailos R (1985) Radiation optic neuropathy. Ophthalmology 92: 1118–1126
Koten JW, der Kindren DJ, Otter WD (1988) Editorial reply. N Engl J Med 318: 581–582
Lennox EL, Draper GJ, Sanders BM (1975) Retinoblastoma: a study of natural history and prognosis of 268 cases. Br Med J 3: 731–734
Leske MC, Sperduto RD (1983) The epidemiology of senile cataracts: a review. Am J Epidemiol 118: 152–165
Lommatzsch P (1968) Morphologische und funktionelle Veränderungen des Kaninchenauges nach Einwirkung von Betastrahlen auf den dorsalen Bulbusabschnitt. Graefes Arch Klin Exp Ophthalmol 176: 100–125
Lommatzsch P (1973) Experiences in the treatment of malignant melanoma of the choroid with 106Ru/106Rh beta ray applicators. Trans Ophthalmol Soc UK 93: 119–132
Lommatzsch P (1983) β-Irradiation of choroidal melanoma with 106Ru/106Rh applicators. Arch Ophthalmol 101: 713–717
Lommatzsch P, Weise B, Ballin R (1986) Ein Beitrag zur Optimierung der Bestrahlungszeit bei der Behandlung des malignen Melanoms der Aderhaut mit β- Applikatoren (106Ru/106Rh). Klin Monatsbl Au- genheilkd 189: 133–140
Margileth DA, Poplack DG, Pizzo PA, Leventhal BG, (1977) Blindness during remission in two patients with acute lymphoblastic leukemia. Cancer 39: 58
Martins AN, Johnston JS, Henry JM (1977) Delayed radiation necrosis of the brain. J Neurosurg 47: 336–345
McCormick B, Ellsworth R, Abramson D, Haik B, Tome M, Grbowski E, LoSasso T (1988) Radiation therapy for retinoblastoma: comparison of results with lens-sparing versus lateral beam techniques. Int J Radiat Oncol Biol Phys 15: 567–574
McFaul PA (1977) Local radiotherapy in the treatment of malignant melanoma of the choroid. Trans Ophthalmol Soc UK 97: 421–427
McFaul PA, Bedford MA (1970) Ocular complications after therapeutic irradiation. Br J Ophthalmol 54: 237–247
Meadows AT, Strong LC, Li FP et al. (1980) Bone sarcomas as a second malignant neoplasm in children: influence of radiation and genetic predisposition. Cancer 46: 532–538
Meadows AT, Baum E, Fossati-Bellami F et al. (1985) Second malignant neoplasms in children: an update from the late effects study group. J Clin Oncol 3: 532–538
Merriam GR (1955) Late effects of β-radiation on the eye. AMA Arch Ophthalmol 53: 708–717
Merriam GR (1956) A clinical study of radiation cataracts. Trans Am Ophthalmol Soc 54: 611–653
Merriam GR, Focht EF (1962) A clinical and experimental study of the effect of single and divided doses of radiation on cataract production. Trans Am Ophthalmol Soc 60: 35–52
Merriam GR, Szechter A, Focht EF (1972) The effects of ionizing radiations on the eye. Front Radiat Ther Oncol 6: 346–385
Messmer EP, Richter HJ, Hopping W, Havers W, Alberti W (1987) Nichtokulärer, maligner Zweittumor nach Spontanheilung eines Retinoblastoms. Klin Monatsbl Augenheilkd 19: 299–303
Mikhael MA (1979) Radiation necrosis of the brain: correlation between patterns on computed tomography and dose of radiation. J Comput Assist Tomogr 3: 241–249
Nakissa N, Rubin P, Strohl R, Keys H (1983) Ocular and orbital complications following radiation therapy of paranasal sinus malignancies and review of literature. Cancer 51: 980–986
Noble KG, Kupersmith MJ (1984) Retinal vascular remodelling in radiation retinopathy. Br J Ophthalmol 68: 475–478
Noell WK (1962) x-Irradiation studies on mammalian retina. In: Haley Snider (eds) Response of the nervous system to ionizing radiation. Academic, New York
Parsons JT, Fitzgerald CR, Hood CI, Ellingwood KE, Bova FJ, Million RR (1983) The effects of irradiation on the eye and optic nerve. Int J Oncol Biol Phys 9: 609–612
Perrers-Taylor M, Brinkley D, Reynolds T (1965) Chor- oido-retinal damage as a complication of radiotherapy. Acta Radiol 3: 431–440
Poppe E (1942) Experimental investigations of the effects of roentgen rays on the eye. Thesis, Oslo
Reese AB, Merriam GR, Martin HE (1949) Treatment of bilateral retinoblastoma by irradiation and surgery. Am J Ophthalmol 32: 175
Riedel KG, Stefani FH, Kampik A (1983) Histopathologis- che Veränderungen im proximalen Fascikulus optikus nach therapeutischer Bestrahlung. Fortschr Ophthalmol 80: 48–52
Riedel KG, Svitra PP, Seddon JM et al. (1985) Proton beam irradiation and hyperthermia. Effects on experimental choroidal melanoma. Arch Ophthalmol 103: 1862–1869
Riedel KG, Schaal GS, Svitra PP, Albert DM, Finger PT, Packer S (1987) Ocular changes following combined microwave hyperthermia and beta-irradiation in rabbit eyes. Invest Ophthalmol Vis Sci 28: 59
Ross HS, Rosenberg S, Friedman AH (1973) Delayed radiation necrosis of the optic nerve. Am J Ophthalmol 76: 683–686
Rubin PH, Casarett GW (1968) Organs of special sense: the eye and the ear. In: Rubin PH, Casarett GW (eds) Clinical radiation pathology. WB Sauders, Philadelphia, pp 662–719
Sagerman RH, Cassady JR, Tretter P, Ellsworth RM (1969) Radiation induced neoplasia following external beam therapy for children with retinoblastoma. AJR 105: 529–535
Schimke RN, Lowman JT, Cowan GAB (1974) Retinoblastoma and osteogenic sarcoma in siblings. Cancer 34: 2077–2079
Schipper J (1983) An accurate and simple method for megavoltage irradiation therapy of retinoblastoma. Radiother Oncol 1: 31–41
Schipper J, Alberti W (1985) Letter to the editor. Ophthalmology 92: 60a–62a
Schipper J, Lagendijk JJW (1986) The treatment of Tetinoblastoma by fractionated radiotherapy combined with hyperthermia. In: Anghileri LJ, Robert J (eds) Hyperthermia in cancer treatment. CRC Press, Boca Raton, FI, pp 79–87
Schipper J, Rutgers DH (1983) The dose-response relationship for cataracts arising after fractionated irradiation of the entire posterior portion of the lens of the rabbit. Proceedings of the 7th International Congress of Radiation Research, July 1983, Amsterdam, C 2–12
Schipper J, Tan KEWP, van Peperzeel HA (1985) Treatment of retinoblastoma by precision megavoltage radiation therapy. Radiother Oncol 3: 117–132
Schipper J, Lagendijk JJW, Tan KEWP (in press) Hyperthermia in the treatment of intraocular tumors, in particular retinoblastoma. In: Alberti W, Sagerman RH (eds) Radiotherapy of intraocular and orbital tumors. Springer, Heidelberg, Berlin, New York
Schlienger P, Calle R, Haye C, Vilcoq JR (1985) Sarcomes osseux et tumeurs malignes de la retine. Bull Cancer 72: 16–24
Shan IC, Arien M, Miller T (1974) Osteogenic sarcoma developing after radiotherapy for retinoblastoma. Ann Surg 40: 485–490
Shields JA, Augsburger JJ, Brady LW, Day IL Cobalt plaque therapy for posterior uveal melanomas. Ophthalmology 89: 1201–1207
Shukovsky LJ, Fletcher GH (1972) Retinal and optic nerve complications in a high dose irradiation technique of ethmoid sinus and nasal cavity. Radiology 104: 629–634
Smith LM, Donaldson SS, Egbert PR, Link MP, Bagshaw MA (1989) Aggressive management of second primary tumors in survivors of hereditary retinoblastoma. Int J Radiat Oncol Biol Phys 17: 499–505
Soloway HB (1966) Radiation induced neoplasms following curative therapy for retinoblastoma. Cancer 19: 1984–1988
Stallard HB (1933) Radient energy as (a) a pathogenic, (b) a therapeutic agent in ophthalmic disorders. Br J Ophthalmol, Monograph Supplement 6
Stallard HB (1966) Radiotherapy for malignant melanoma of the choroid. Br J Ophthalmol 50: 147–155
Tarr KH, Constable IJ (1981) Radiation damage after pterygium treatment. Aust J Ophthalmol 9: 97–101
Thompson GM, Migdal CS, Whittle RJM (1983) Radiation retinopathy following treatment of posterior nasal space carcinoma. Br J Ophthalmol 67: 609–614
Wara WM, Irvine AR, Neger RE, Howes EL, Phillips TL (1979) Radiation retinopathy. Int J Radiat Oncol Biol Phys 5: 81–83
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Alberti, W. (1991). Effects of Radiation on the Eye and Ocular Adnexa. In: Scherer, E., Streffer, C., Trott, KR. (eds) Radiopathology of Organs and Tissues. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83416-5_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-83416-5_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83418-9
Online ISBN: 978-3-642-83416-5
eBook Packages: Springer Book Archive