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Endothelial Surface Charge: Blood-Brain Barrier Opening to Horseradish Peroxidase Induced by the Polycation Protamin Sulfate

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Experimental and Clinical Neuropathology

Part of the book series: Acta Neuropathologica Supplementum ((NEUROPATHOLOGIC,volume 7))

Summary

Perfusion of rat brain with the polycation protamin sulfate caused a decrease in the stainability of luminal surface of cerebral endothelium to positively charged colloidal iron. This change reflecting a decrease in the anionic sites of the endothelial plasma membrane was accompanied by opening of the blood-brain barrier to horseradish peroxidase. The polyanion heparin reversed colloidal iron binding but failed to prevent permeability alteration of the cerebral endothelium.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Semmelweis Medical University, H-1083, Budapest, Balassa-u 6, Hungary

    Dr. Z. Nagy

  2. Department of Pathology, McGill University Montreal, Canada

    H. Peters & I. Hüttner

Authors
  1. Dr. Z. Nagy
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  2. H. Peters
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  3. I. Hüttner
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Editor information

Editors and Affiliations

  1. Ludwig Boltzmann-Institute of Clinical Neurobiology, Lainz-Hospital, Wolkersbergenstraße 1, 1130, Wien, Austria

    Kurt Jellinger (Director) (Director)

  2. Institut für Neuropathologie, Universität Bonn, 5300, Bonn-Venusberg, Germany

    Filippo Gullotta

  3. Institute of Brain Research, Polish Academy of Sciences, 3, ul. Dworkowa, Warsaw, Poland

    Miroslav Mossakowski (Director) (Director)

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© 1981 Springer-Verlag

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Nagy, Z., Peters, H., Hüttner, I. (1981). Endothelial Surface Charge: Blood-Brain Barrier Opening to Horseradish Peroxidase Induced by the Polycation Protamin Sulfate. In: Jellinger, K., Gullotta, F., Mossakowski, M. (eds) Experimental and Clinical Neuropathology. Acta Neuropathologica Supplementum, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81553-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-81553-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10449-0

  • Online ISBN: 978-3-642-81553-9

  • eBook Packages: Springer Book Archive

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