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Pathogenesis of Secondary Brain Hemorrhage After Ischemia: Lessons from Animal Models … and a few from man: too!

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Thrombolytic Therapy in Acute Ischemic Stroke II

Abstract

Both open label and controlled clinical trials of thrombolytic therapy for acute stroke are careful to define and distinguish between hemorrhagic infarctions and intracerebral hematomas in addressing possible complications of treatment. Since the major and potentially unacceptable risk of this type of treatment is brain hemorrhage [16, 17] and because certain types of stroke are apt to produce some hemorrhagic complications as part of the untreated natural history [22, 23], it has become very important to stratify and quantitate secondary brain hemorrhages at least into two strata, acceptable and unacceptable.

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Authors and Affiliations

  1. Department of Neurology, George Washington University Medical Center, Washington, DC, USA

    G. F. Molinari

Authors
  1. G. F. Molinari
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Editor information

Editors and Affiliations

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Gregory J. del Zoppo M.D.

  2. Neurology Service, Hyogo Brain and Heart Center at Himeji, 520 Saisho-ko, Himeji, 670, Japan

    Etsuro Mori M.D.

  3. Neurologische Klinik, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 400, W-6900, Heidelberg 1, Germany

    Werner Hacke

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© 1993 Springer-Verlag Berlin Heidelberg

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Molinari, G.F. (1993). Pathogenesis of Secondary Brain Hemorrhage After Ischemia: Lessons from Animal Models … and a few from man: too!. In: del Zoppo, G.J., Mori, E., Hacke, W. (eds) Thrombolytic Therapy in Acute Ischemic Stroke II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78061-5_5

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  • DOI: https://doi.org/10.1007/978-3-642-78061-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56442-3

  • Online ISBN: 978-3-642-78061-5

  • eBook Packages: Springer Book Archive

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