Thrombolytic Therapy in Acute Ischemic Stroke II

  • Gregory J. del Zoppo
  • Etsuro Mori
  • Werner Hacke

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Background to Thrombolytic Therapy in Acute Ischemic Stroke

  3. Clinical Trials of Fibrinolytic Agents in Carotid Territory Cerebral Ischemia

    1. Front Matter
      Pages 37-37
    2. M. Kaste, C. Fieschi, W. Hacke, E. Lesaffre, M. Verstraete, J. Fröhlich
      Pages 66-71
    3. E. Lesaffre, I. Scheys, J. Fröhlich, E. Bluhmki
      Pages 72-79
    4. G. A. Donnan, S. M. Davis, B. R. Chambers, P. C. Gates, G. J. Hankey, E. G. Stewart-Wynne et al.
      Pages 80-85
  4. Other Applications of Fibrinolytic Agents in the Central Nervous System

  5. Insights into the Pathogenesis of Cerebral Ischemia Relevant to Fibrinolysis

  6. Diagnosis and Assessment of Outcomes in Acute Cerebral Ischemia

  7. Ancillary Therapy for Cerebrovascular Reperfusion

  8. Open Communications

About these proceedings


Over the last decade, interest in treatment of ischemic stroke has increased significantly. Perhaps the single most important feature of attempts to improve the outcome of stroke patients has been that the interventions be applied within the very early hours of stroke symptoms. This has spawned efforts to understand the vascular and neuronal responses to cerebral artery reperfusion experimentally. Important prospective clinical studies of thrombolysis in acute ischemic stroke have been completed, and large placebo-controlled, symptom-based studies are now underway worldwide. Here, we consider the central features of those studies, their experimental basis, and the future importance of adjunctive therapies to recanalization in focal brain ischemia acutely. Risks and benefits are discussed. This collection benefits from the opinions of experts and workers in this rapidly evolving and exciting field.


Intensivmedizin Nervous System Neurologie Schlaganfall Thrombolyse computed tomography (CT) diagnosis

Editors and affiliations

  • Gregory J. del Zoppo
    • 1
  • Etsuro Mori
    • 2
  • Werner Hacke
    • 3
  1. 1.Department of Molecular and Experimental Medicine, The Scripps Research Institute and Division of Hematology/Medical OncologyScripps Clinic and Research FoundationLa JollaUSA
  2. 2.Neurology ServiceHyogo Brain and Heart Center at HimejiHimeji, 670Japan
  3. 3.Neurologische KlinikRuprecht-Karls-Universität HeidelbergHeidelberg 1Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-56442-3
  • Online ISBN 978-3-642-78061-5
  • Buy this book on publisher's site