Abstract
The purpose of this work was to develop a technique for simulating SPECT projection data which realistically model a cardiac T1-201 study. The data are intended for use in evaluating image reconstruction and processing algorithms using ROC analysis. The significant physical effects of T1-201 patient acquisitions have been incorporated into the simulation, including patient anatomy, attenuation, scatter, detector response, and statistical noise fluctuations. The simulation technique involves first generating a 3D source distribution which models the radioisotope uptake of a clinical T1-201 study. A patient CT image provides an anatomical model for generating the distribution. Next, projections are calculated as ray-sums in a way which incorporates photon attenuation and detector response. Detailed attenuation information is provided by the CT image. The effects of scatter are then incorporated by filtering the projection data at each angle with an estimate of the scatter response function specific for that angle. Finally, Poisson noise is added to the projections. The results have shown that the simulation technique generates data closely modeling clinical T1-201 data.
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© 1992 Springer-Verlag Berlin Heidelberg
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Gilland, D.R., Tsui, B.M.W., Hu, HB., Perry, J.R. (1992). Computer Simulated Cardiac SPECT Data for use in Evaluating Reconstruction Algorithms. In: Todd-Pokropek, A.E., Viergever, M.A. (eds) Medical Images: Formation, Handling and Evaluation. NATO ASI Series, vol 98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77888-9_25
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DOI: https://doi.org/10.1007/978-3-642-77888-9_25
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