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Neuroendocrine Carcinoma of the Uterus

  • Chapter
Gynecological Tumors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 85))

Abstract

The production of hormones by cervical carcinomas has been reported, albeit infrequently, since 1961 (Berthelot et al. 1961); these tumors are now considered to be neuroendocrine carcinomas. Until now, more than 140 cases have been described in case reports or in clinicopathologic analyses. Similar neuroendocrine tumors are also known to develop in the endometrium.

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References

  • Aguirre P, Scully RE, Wolfe HJ, Delellis RA (1984) Endometrial carcinoma with argyrophil cells. Hum Pathol 15: 210–217

    Article  PubMed  CAS  Google Scholar 

  • Albores-Saavedra J, Larraza 0, Poucell S, Rodriguez-Martinez HA (1976) Carcinoid of the uterine cervix. Additional observation on a new tumor entity. Cancer 38: 2328–2342

    Google Scholar 

  • Albores-Saavedra J, Rodriguez-Martinez HA, Larraza-Hernandez O (1979) Carcinoid tumors of the cervix. Pathol Annu 14: 273–291

    PubMed  Google Scholar 

  • Arrigoni MG, Woolner LB, Bernatz PE (1972) Atypical carcinoid tumors of the lung. J Thorac Cardiovasc Surg 64: 413–421

    PubMed  CAS  Google Scholar 

  • Azzopardi JG, Hou LT (1965) Intestinal metaplasia with argentaffin cells in cervical adenocarcinoma. J Pathol Bacteriol 90: 686–690

    Article  PubMed  CAS  Google Scholar 

  • Azzopardi JG, Pollack DJ (1963) Argentaffin and argyrophil cells in gastric carcinoma. J Pathol Bacteriol 86: 443–452

    Article  PubMed  CAS  Google Scholar 

  • Bannatyne P, Russell P, Wills E (1983) Argyrophilia and endometrial carcinoma. Int J Gynecol Pathol 2: 235–254

    Article  PubMed  CAS  Google Scholar 

  • Barrett RJ II, Davos I, Leuchter RS, Lagasse LD (1987) Neuroendocrine features in poorly differentiated and undifferentiated carcinomas of the cervix. Cancer 60: 2325–2330

    Article  PubMed  Google Scholar 

  • Bensch KG, Corrin B, Pariente R, Spencer H (1968) Oat-cell carcinoma of the lung: its origin and relationship to bronchial carcinoid. Cancer 22: 1163–1172

    Article  PubMed  CAS  Google Scholar 

  • Berthelot P, Benhamou JP, Fauvert R (1961) Hypercorticisme et cancer de l’utérus. Presse Med 69: 189–190

    Google Scholar 

  • Black WC (1968) Enterchromaffin cell types and corresponding carcinoid tumors. Lab Invest 19: 473–486

    PubMed  Google Scholar 

  • Bonar SF, Sweeney EC (1986) The prevalence, prognostic significance and hormonal content of endocrine cells in gastric cancer. Histopathology 10: 53–63

    Article  PubMed  CAS  Google Scholar 

  • Caillaud J-M, Benjelloun S, Bosq J, Braham K, Lipinski M (1984) HNK-1-defined antigen detected in paraffin-embedded neuroectoderm tumors and those derived from cells of the amine precursor uptake and decarboxylation system. Cancer Res 44: 4432–4439

    PubMed  CAS  Google Scholar 

  • Chan JKC, Tsui WMS, Tung SY, Ching RCT (1989) Endocrine cell hyperplasia of the uterine cervix. A precursor of neuroendocrine carcinoma of the cervix? Am J Clin Pathol 92: 825–830

    PubMed  CAS  Google Scholar 

  • Clayton F, Sibley RK, Ordonez NG, Hansson G (1982) Argyrophilic breast carcinomas: evidence of lactational differentiation. Am J Surg Pathol 6: 323–333

    Article  PubMed  CAS  Google Scholar 

  • Cox WF, Pierce GB (1982) The endodermal origin of the endocrine cells of an adenocarcinoma of the colon of rat. Cancer 50: 1530–1538

    Article  PubMed  Google Scholar 

  • Daw E (1977) Carcinoid tumour of the cervix. Postgrad Med J 53: 272–273

    Article  PubMed  CAS  Google Scholar 

  • Delellis RA, Dayal Y, Wolfe HJ (1984) Carcinoid tumors. Changing concepts and new perspectives. Am J Surg Pathol 8: 295–300

    Google Scholar 

  • DiSant’Agnese PA, DeMesy Jensen KL (1987) Neuroendocrine differentiation in prostatic carcinoma. Hum Pathol 18: 849–856

    Article  Google Scholar 

  • Driessens J, Clay A, Adenis L, Demaille A (1964) Tumeur cervico-utérine et syndrome biologique de carcinoïdose. Arch Anat Pathol 12: 200–203

    CAS  Google Scholar 

  • Ferry JA, Scully RE (1988) “Adenoid cystic” carcinoma and adenoid basal carcinoma of the uterine cervix. A study of 28 cases. Am J Surg Pathol 12:134–144

    Google Scholar 

  • Fontaine J, LeDourain NM (1977) Analysis of endoderm formation in the avian blastderm by the use of quail-chick chimeras: the problem of the neuroectodermal origin of the cells of the APUD series. J Embryol Exp Morphol 41: 209–222

    PubMed  CAS  Google Scholar 

  • Fox H, Kazzaz B, Langley FA (1964) Argyrophil and argentaffin cells in the female genital tract and in ovarian mucinous cysts. J Pathol Bacteriol 88: 479–488

    Article  PubMed  CAS  Google Scholar 

  • Fujii S, Konishi I, Ferenczy A, Imai K, Okamura H, Mori T (1986) Small cell undifferentiated carcinoma of the uterine cervix: histology, ultrastructure, and immunohistochemistry of two cases. Ultrastruct Pathol 10: 337–346

    Article  PubMed  CAS  Google Scholar 

  • Gersell DJ, Mazoujian G, Mutch DG, Rudloff MA (1988) Small-cell undifferentiated carcinoma of the cervix. Am J Surg Pathol 12: 684–698

    Article  PubMed  CAS  Google Scholar 

  • Gould VE, Linnoila RI, Memoli VA, Warren WH (1983) Neuroendocrine cells and neuroendocrine neoplasms of the lung. Pathol Annu 18: 287–330

    PubMed  Google Scholar 

  • Gould VE, Jao W, Chejfec G, Banner BF, Bonomi P (1984) Neuroendocrine carcinomas of the gastrointestinal tract. Semin Diagn Pathol 1: 13–18

    PubMed  CAS  Google Scholar 

  • Gould VE, Wiedenmann B, Lee I et al. (1987) Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry. Am J Pathol 126: 243–257

    PubMed  CAS  Google Scholar 

  • Graziano SL, Gowan BY, Carney DN et al. (1987) Small cell lung cancer cell line derived from a primary tumor with a characteristic deletion of 3p. Cancer Res 47: 2148–2155

    PubMed  CAS  Google Scholar 

  • Grimelius L, Wilander E (1980) Silver stains in the study of endocrine cells of the gut and pancreas. Invest Cell Pathol 3: 3–12

    PubMed  CAS  Google Scholar 

  • Groben P, Reddick R, Askin F (1985) The pathologic spectrum of small cell carcinoma of the cervix. Int J Gynecol Pathol 4: 42–57

    Article  PubMed  CAS  Google Scholar 

  • Habib A, Kaneko M, Cohen CJ, Walker G (1979) Carcinoid of the uterine cervix. A case report with light and electron microscopic study. Cancer 43: 535–538

    Google Scholar 

  • Hariri J, Rasmussen EA, Hage E (1983) Carcinoid tumor of the uterine cervix. Acta Obstet Gynecol Scand 62: 539–540

    Article  PubMed  CAS  Google Scholar 

  • Hirsch FR, Matthews MJ, Aisner S et al. (1988) Histopathologic classification of small cell lung cancer. Changing concepts and terminology. Cancer 62: 973–977

    Google Scholar 

  • Hus C, Wong LC, Chan CW (1981) Nonendocrine carcinoid tumor of the uterine cervix. Aspects of diagnosis and treatment. Case report. Br J Obstet Gynecol 88: 1056–1060

    Google Scholar 

  • Husain AN, Gattuso P, Abraham K, Castelli MJ (1989) Synchronous adenocarcinoma and carcinoid of the uterine cervix: immunohistochemical study of a case and review of literature. Gynecol Oncol 33: 125–128

    Article  PubMed  CAS  Google Scholar 

  • Ichimura H, Yamasaki M, Yamane T, Shimizu H, Katsumoto T, Kurimura O, Kurimura T (1988) Heterotransplantation of argyrophil small cell carcinoma of the uterine cervix integrating HPV16DNA into nude mice. Jpn J Cancer Res (Gann) 79: 1255–1258

    Article  CAS  Google Scholar 

  • Inoue M, Ueda G, Yamasaki M et al. (1982) Endometrial argyrophil cell adenocarcinoma with indole-or catecholamine precursor uptake and decarboxylation. Int J Gynecol Pathol 1:47–58 Inoue M, Inafuku S, Okano K, Minagawa J, Mori H (1984a) Cervical carcinoid associated with adenocarcinoma and squamous cell carcinoma. J Jpn Soc Clin Cytol 23: 455–460

    Google Scholar 

  • Inoue M, Ueda G, Yamasaki M, Tanaka Y, Hiramatsu K (1984b) Immunohistochemical demonstration of peptide hormones in endometrial carcinomas. Cancer 54: 2127–2131

    Article  PubMed  CAS  Google Scholar 

  • Inoue M, Ueda G, Nakajima T (1985) Immunohistochemical demonstration of neuron-specific enolase in gynecologic malignant tumors. Cancer 55: 1686–1690

    Article  PubMed  CAS  Google Scholar 

  • Inoue M, DeLellis RA, Scully RE (1986) Immunohistochemical demonstration of chromogranin in endometrial carcinomas with argyrophil cells. Hum Pathol 17: 841–847

    Article  PubMed  CAS  Google Scholar 

  • Iwafuchi M, Watanabe H, Ishihara N, Enjoji M, Iwashita A, Yanaihara N, Ito S (1987) Neoplastic endocrine cells in carcinomas of the small intestine: histochemical and immunohistochemical studies of 24 tumors. Hum Pathol 18: 185–194

    Article  PubMed  CAS  Google Scholar 

  • Iwaoki Y, Nogawa T, Katsube Y, Fujiwara A (1986) A case of the cervical carcinoid tumor. Cytologic, histologic, and electronmicroscopic study. J Jpn Soc Clin Cytol 25: 150–156

    Google Scholar 

  • Jacobs AJ, Marchevsky A, Gordon RE, Deppe G, Cohen CJ (1980) Oat cell carcinoma of the uterine cervix in a pregnant woman treated with cis-diamminedichloroplatinum. Gynecol Oncol 9: 405410

    Google Scholar 

  • Johannessen JV, Davy M, Capella C, Sobrinho-Simoes M, Solcia E (1980) Endocrine cell carcinoma of the uterine cervix. Diagn Gynecol Obstet 2: 127–134

    PubMed  CAS  Google Scholar 

  • Jones HW III, Plymate S, Gluck FB, Miles PA, Greene JF Jr (1976) Small cell nonkeratinizing

    Google Scholar 

  • carcinoma of the cervix associated with ACTH production. Cancer 38:1629–1635

    Google Scholar 

  • Kaku T, Enjoji M (1983) Extremely well-differentiated adenocarcinoma (“adenoma malignum”) of the cervix. Int J Gynecol Pathol 2: 28–41

    Article  PubMed  CAS  Google Scholar 

  • Kamiya H, Nagai S, Sakai K, Kudo R (1986) A case report of so called “carcinoid tumor of the uterine cervix”. J Jpn Soc Clin Cytol 25: 808–815

    Google Scholar 

  • Katsube Y, Teramoto H, Nomura K, Miyagawa K, Ifuji H, Namba K (1984) A case of carcinoid tumor of the uterine cervix containing serotonin. Jpn J Cancer Clin 38: 198–204

    Google Scholar 

  • Kiang DT, Bauer GE, Kennedy BJ (1973) Immunoassayable insulin in carcinoma of the cervix associated with hypoglycemia. Cancer 31: 801–805

    Article  PubMed  CAS  Google Scholar 

  • Kodousek R, Gazarek F, Dusek J, Dostal S (1976) Malignant “apudoma” (argyrophil cell cancer) of the uterine cervix in a 24-year old woman in pregnancy. Cs Patol 12: 37–44

    CAS  Google Scholar 

  • Kumar N (1984) Small-cell carcinoma of the endometrium in a 23-year-old woman: light microscopic and ultrastructural study. Am J Clin Pathol 31: 98–101

    Google Scholar 

  • Lewin K (1987) Carcinoid tumors and the mixed (composite) glandular endocrine cell carcinomas. Am J Surg Pathol 11: 71–86

    Article  PubMed  Google Scholar 

  • Lloyd RV, Mervak T, Schmidt K, Warner TFCS, Wilson BS (1984) Immunohistochemical detection of chromogranin and neuron-specific enolase in pancreatic endocrine neoplasms. Am J Surg Pathol 8: 607–614

    Article  PubMed  CAS  Google Scholar 

  • Lojek MA, Fer MF, Kasselberg AG et al. (1980) Cushing’s syndrome with small cell carcinoma of the uterine cervix. Am J Med 69: 140–144

    Article  PubMed  CAS  Google Scholar 

  • Louka MH, Danoff B, Brodovsky HS, Jahshan AE (1982) Carcinoid tumor of the uterine cervix. Respone to combination chemotherapy and radiotherapy. Am J Clin Oncol 5: 487–493

    Google Scholar 

  • Lundqvist M, Wilander E, Esscher T, Pahlman S (1985) Neuron-specific enolase in mucosal endocrine cells and carcinoid tumours of the small intestine: a comparative study with neuron-specific enolase immunocytochemistry and silver stains. Histochem J 17: 323–331

    Article  PubMed  CAS  Google Scholar 

  • Mackay B, Osborne BM, Wharton JT (1979) Small cell tumor of cervix with neuroepithelial features. Ultrastructural observations in two cases. Cancer 43: 1138–1145

    Google Scholar 

  • Manivel C, Wick MR, Sibley RK (1986) Neuroendocrine differentiation in müllerian neoplasms. An immunohistochemical study of a “pure” endometrial small-cell carcinoma and a mixed müllerian tumor containing small-cell carcinoma. Am J Clin Pathol 86: 438–443

    Google Scholar 

  • Matsuyama M, Inoue T, Ariyoshi Y et al. (1979) Argyrophil cell carcinoma of the uterine cervix with ectopic production of ACTH, ß-MSH, serotonin, histamine, and amylase. Cancer 44: 1813–1823

    CAS  Google Scholar 

  • Michels S, Swanson PE, Robb JA, Wick MR (1987) Leu-7 in small cell neoplasms. An immunohistochemical study with ultrastructural correlations. Cancer 60: 2958–2964

    Google Scholar 

  • Miles PA, Greenberg H, Herrera GA, Rawding-Patterson G (1982) Primary carcinoid tumor of the uterine cervix presenting as adenosquamous carcinoma. Diagn Gynecol Obstet 4: 327–337

    PubMed  CAS  Google Scholar 

  • Miwa A, Kitagawa M, Terada S (1981) So-called malignant apudoma of the uterine cervix. Postmortem findings and electron microscopic observation. Jpn J Cancer Clin 27: 178–184

    Google Scholar 

  • Mullins JD, Hillard GD (1981) Cervical carcinoid (“argyrophil cell” carcinoma) associated with an endocervical adenocarcinoma: a light and ultrastructural study. Cancer 47: 785–790

    Article  PubMed  CAS  Google Scholar 

  • Muraoka S, Takahashi T, Ando M, Nishikawa Y, Fujita M, Shimoda A (1987) Minute carcinoid tumor of the uterine cervix associated with microinvasive adenocarcinoma, with reference to its histogenesis. Acta Pathol Jpn 37: 1183–1198

    PubMed  CAS  Google Scholar 

  • Oberndorfer S (1907) Karzinoide Tumoren des Dünndarms. Frankf Z Pathol 1: 426–429

    Google Scholar 

  • Okudaira Y, Tateishi R, Sato Y, Saji F, Hayakawa K, Matsui Y, Sawada M (1980) Argyrophil cell of the endometrial adenocarcinoma. Acta Obstet Gynecol Jpn 32: 1541–1550

    CAS  Google Scholar 

  • Olson N, Twiggs L, Sibley R (1982) Small-cell carcinoma of the endometrium: light microscopic and ultrastructural study of a case. Cancer 50: 760–765

    Article  PubMed  CAS  Google Scholar 

  • Ooi A, Mai M, Ogino T et al. (1988) Endocrine differentiation of gastric adenocarcinoma. The prevalence as evaluated by immunoreactive chromogranin A and its biologic significance. Cancer 62: 1096–1104

    Google Scholar 

  • Ouchi K, Matsuo Y, Yahata K et al. (1981) A case report of oat cell carcinoma of the cervix, suggested by cytology and confirmed by electronmicroscope. J Jpn Soc Clin Cytol 20: 572–577

    Google Scholar 

  • Paz R, Frigerio B, Sundblad A, Eusebi V (1985) Small cell (oat cell) carcinoma of the endometrium. Arch Pathol Lab Med 109: 270–272

    PubMed  CAS  Google Scholar 

  • Pazdur R, Bonomi P, Slayton R et al. (1981) Neuroendocrine carcinoma of the cervix: implications for staging and therapy. Gynecol Oncol 12: 120–128

    Article  PubMed  CAS  Google Scholar 

  • Pearse AGE (1969) The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem 17: 303–313

    Article  PubMed  CAS  Google Scholar 

  • Picket RL, Rall LB, Phelps P, Rutter WJ (1976) The neural crest and the origin of insulin-producing and other gastrointestinal hormone-producing cells. Science 191: 191–192

    Article  Google Scholar 

  • Radi MJ, Fenoglio-Preiser CM, Bartow SA, Key CR, Pathak DR (1986) Gastric carcinoma in the young: a clinico-pathological and immuno-histochemical study. Am J Gastroenterol 81: 747–756

    PubMed  CAS  Google Scholar 

  • Reagan JW, Mamonic MS, Wentz WB (1957) Analytical study of the cells in cervical squamous cell cancer. Lab Invest 6: 241–250

    PubMed  CAS  Google Scholar 

  • Said JW, Vimadalal S, Nash G, Shintaku IP, Heusser RC, Sassoon AF, Lloyd RV (1985) Immunoreactive neuron-specific enolase, bombesin, and chromogranin as markers for neuroendocrine lung tumors. Hum Pathol 16: 236–240

    Article  PubMed  CAS  Google Scholar 

  • Sakamoto Y, Kishi Y, Yamamoto Y, Ino H (1982) Carcinoid tumor (argyrophil cell carcinoma) in the uterine cervix: with special reference to cytologic figures. J Jpn Soc Clin Cytol 21: 702–708

    Google Scholar 

  • Satake T, Matsuyama M (1987) Argyrophil cells in normal endometrial glands. Virchows Arch [A] 410: 449–454

    Article  CAS  Google Scholar 

  • Satake T, Matsuyama M, Kuzuya K, Suchi T, Sato T (1982) Argyrophil reactive cells in the normal uterus and differentiated endometrial carcinoma. Acta Pathol Jpn 32: 1017–1026

    PubMed  CAS  Google Scholar 

  • Sato Y, Ozaki M, Ueda G, Tanizawa 0 (1986) Clinical significance of argyrophilia in endometrial carcinomas. Gynecol Oncol 25: 53–60

    CAS  Google Scholar 

  • Scully RE, Aguirre P, DeLellis RA (1984) Argyrophilia, serotonin, and peptide hormones in the female genital tract and its tumors. Int J Gynecol Pathol 3: 51–70

    Article  PubMed  CAS  Google Scholar 

  • Seidel R Jr, Steinfeld A (1988) Carcinoid of the cervix: natural history and implications for therapy. Gynecol Oncol 30: 114–119

    Article  PubMed  Google Scholar 

  • Sheets EE, Berman ML, Hrountas CK, Liao SY, DiSaia PH (1988) Surgically treated, early-stage neuroendocrine small-cell cervical carcinoma. Obstet Gynecol 71: 10–14

    PubMed  CAS  Google Scholar 

  • Silva EG, Kott MM, Ordonez NG (1984) Endocrine carcinoma intermediate cell type of the uterine cervix. Cancer 54: 1705–1713

    Article  PubMed  CAS  Google Scholar 

  • Smith DM Jr, Haggitt RC (1984) The prevalance and prognostic significance of argyrophil cells in colorectal carcinomas. Am J Surg Pathol 8: 123–128

    Article  PubMed  Google Scholar 

  • Stahl R, Demopoulos RI, Bigelow B (1981) Carcinoid tumor within a squamous cell carcinoma of the cervix. Gynecol Oncol 11: 387–392

    Article  PubMed  CAS  Google Scholar 

  • Stassart J, Crum CP, Yodan EL, Fenoglio CM, Richart RM (1982) Argyrophilic carcinoma of the cervix. A report of a case with coexisting cervical intraepithelial neoplasia. Gynecol Oncol 13: 247–251

    Google Scholar 

  • Stockdale AD., Leader M, Phillips RH, Henry K (1986) The carcinoid syndrome and multiple hormone secretion associated with a carcinoid tumour of the uterine cervix. Case report. Br J Obstet Gynecol 93: 397–401

    Google Scholar 

  • Stratton M, Evans DJ, Lampert IA (1986) Effects of oestrogens on endocrine cells in prostatic carcinoma (abstr). J Pathol 148: 83A

    Google Scholar 

  • Sweeney EC, McDonnell L (1980) Atypical gastric carcinoids. Histopathology 4: 215–224

    Article  PubMed  CAS  Google Scholar 

  • Tateishi R, Wada A, Hayakawa K, Hongo J, Ishii S, Terakawa N (1975) Argyrophil cell carcinomas (apudomas) of the uterine cervix. Light and electron microscopic observations of 5 cases Virchows Arch [A] 336: 257–274

    Google Scholar 

  • Taxy JB, Tischler AS, Insalaco S-J, Battifora H (1981) “Carcinoid” tumor of the breast. A variant of conventional breast cancer ? Hum Pathol 12:170–179

    Google Scholar 

  • Tsukamoto N, Hirakawa T, Matsukuma K, Kaku T, Matsuyama T, Kamura T, Saito T (1989) Carcinoma of the uterine cervix with variegated histological patterns and calcitonin production. Gynecol Oncol 33: 395–399

    Article  PubMed  CAS  Google Scholar 

  • Tuji K, Taguchi T, Horinaga T (1978) Fine structural observation of ACTH-producing carcinoid tumor of the uterine cervix. J Clin Electron Microscopy 11: 5–6

    Google Scholar 

  • Turner WA, Gallup DG, Talledo 0E, Otken LB Jr, Guthrie TH (1986) Neuroendocrine carcinoma of the uterine cervix complicated by pregnancy: case report and review of the literature. Obstet Gynecol 67: 80s - 83s

    PubMed  CAS  Google Scholar 

  • Ueda G (1988) Biological behavior of argyrophil carcinoma of the cervix. J Jpn Soc Gynecol Pathol Colposc 6: 47–58

    CAS  Google Scholar 

  • Ueda G, Sato Y, Yamasaki M et al. (1977) Argyrophil cell adenocarcinoma of the endometrium. Acta Obstet Gynecol Jpn 29: 1167–1168

    Google Scholar 

  • Ueda G, Yamasaki M, Inoue M, Kurachi K (1979) A clinicopathologic study of endometrial carcinomas with argyrophil cells. Gynecol Oncol 7: 223–232

    Article  PubMed  CAS  Google Scholar 

  • Ueda G, Yamasaki M, Inoue M, Tanaka Y, Hiramatsu K, Inoue Y, Abe Y (1984a) Immunohistochemical demonstration of peptide hormones in cervical adenocarcinomas with argyrophil cells. Int J Gynecol Pathol 2: 373–379

    Article  PubMed  CAS  Google Scholar 

  • Ueda G, Yamasaki M, Inoue M et al. (1984b) Argyrophil cells in the endometrioid carcinoma of the ovary. Cancer 54: 1569–1573

    Article  PubMed  CAS  Google Scholar 

  • Ueda G, Tanaka Y, Inoue Yet al. (1985) Immunohistochemical demonstration of chromogranin in endometrial carcinomas with argyrophilia. Acta Obstet Gynecol Jpn 37: 2853–2854

    CAS  Google Scholar 

  • Ueda G, Yamasaki M, Inoue M, Tanaka Y, Inoue Y, Abe Y, Tanizawa O (1986) Immunohistochemical demonstration of HNK-1-defined antigen in gynecologic tumors with argyrophilia. Int J Gynecol Pathol 5: 143–150

    PubMed  CAS  Google Scholar 

  • Ueda G, Inoue M, Saito J, Shimizu H, Shimizu C, Sasagawa H, Tanizawa O (1987a) Distribution of epithelial membrane antigen in endometrial carcinoma with argyrophilia. Acta Obstet Gynecol Jpn 39: 998–999

    CAS  Google Scholar 

  • Ueda G, Nishino T, Saito J, Abe Y, Shimizu H, Tanizawa O (1987b) Detection of chromogranin in argyrophil cells of endometrial carcinoma. Gynecol Oncol 27: 159–165

    Article  PubMed  CAS  Google Scholar 

  • Ueda G, Shimizu C, Shimizu H, Saito J, Tanaka Y, Inoue M, Tanizawa 0 (1989) An immunohistochemical study of small-cell and poorly differentiated carcinomas of the cervix using neuroendocrine markers. Gynecol Oncol 34: 164–169

    CAS  Google Scholar 

  • Ulich TR, Liao SY, Layfield L, Romansky S, Cheng L, Lewin KJ (1986) Endocrine and tumor differentiation markers in poorly differentiated small-cell carcinoids of the cervix and vagina. Arch Pathol Lab Med 110: 1054–1057

    PubMed  CAS  Google Scholar 

  • Van Nagell JR Jr, Powell DE, Gallion HH et al. (1988) Small cell carcinoma of the uterine cervix. Cancer 62: 1586–1593

    Article  PubMed  Google Scholar 

  • Wake N, Slocum HK, Rustum YM, Matsui S, Sandberg AA (1981) Chromosomes and causation of human cancer and leukemia. XLIV. A method for chromosome analysis of solid tumor. Cancer Genet Cytogenet 3: 1–10

    Google Scholar 

  • Walker AN, Mills SE, Taylor PT (1988) Cervical neuroendocrine carcinoma: a clinical and light microscopic study of 14 cases. Int J Gynecol Pathol 7: 64–74

    Article  PubMed  CAS  Google Scholar 

  • Warner TFCS (1978) Carcinoid tumor of the uterine cervix. J Clin Pathol 31: 990–995

    Article  PubMed  CAS  Google Scholar 

  • Warren WH, Memoli VA, Gould VE (1988) Well-differentiated and small cell neuroendocrine carcinomas of the lung. Two related but distinct clinicopathologic entities. Virchows Arch [B] 55: 299–310

    Google Scholar 

  • Waxman M, Vuletin JC, Pertshuk DO (1979) Lysosomes in Brenner’s tumor simulating secretory argentaffin granules. Arch Pathol Lab Med 103: 183–186

    PubMed  CAS  Google Scholar 

  • Wick MR, Stanley M, Cherwitz DL, Savage JE (1986) Concomitant neuropeptide-producing endometrial carcinomas and ileal carcinoid tumors. J Clin Pathol 85: 406–410

    CAS  Google Scholar 

  • Yamasaki M, Tateishi R, Hongo J, Ozaki M, Inoue M, Ueda G (1984) Argyrophil small cell carcinomas of the uterine cervix. Int J Gynecol Pathol 3: 146–152

    Article  PubMed  CAS  Google Scholar 

  • Yokota J, Tsukada Y, Nakajima T et al. (1989) Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix. Cancer Res 49: 3598–3601

    PubMed  CAS  Google Scholar 

  • Yoshida A, Yoshida H, Fukunishi R, Inohara T (1984) Carcinoid tumor of the uterine cervix. A light and electron microscopic study. Virchows Arch [A] 402: 331–336

    Google Scholar 

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  1. G. Ueda
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  2. M. Yamasaki
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Editors and Affiliations

  1. Tohoku University School of Medicine, 3-6-12 Kuromatsu, Izumi-Ku, Sendai 981, Japan

    Nobuaki Sasano MD (Professor Emeritus) (Professor Emeritus)

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Ueda, G., Yamasaki, M. (1992). Neuroendocrine Carcinoma of the Uterus. In: Sasano, N. (eds) Gynecological Tumors. Current Topics in Pathology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75941-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-75941-3_10

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