Abstract
The neuronal growth factors nerve growth-factor (NGF) and fibroblast growth factor (FGF) play important roles in the development of both the peripheral and central nervous systems. These agents are survival factors in vivo and in neuronal cell culture. They appear to promote the differentiation of different classes of neurons and may also play some part in the guidance of neuronal process outgrowth. It is apparent that neuronal growth factors, as exemplified by NGF and FGF, encompass an enormous range of actions, making elucidation of the underlying molecular mechanisms a formidable task. However, a multidisciplinary approach has been brought to bear on this task, and studies of neuronal growth factor action have gained from as well as contributed insights to other fields.
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References
Abdel-Latif AA (1986) Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers. Pharmacol Rev 38: 227–272
Akeson R, Warren SL (1986) PC12 adhesion and neurite formation on selected substrates are inhibited by some glycosaminoglycans and a fibronectin-derived tetrapeptide. Exp Cell Res 162: 347–362
Albert KA, Helmer-Matyjek E, Nairn AC, Müller TH, Haycock JW, Greene LA, Goldstein M, Greengard P (1984) Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase. Proc Natl Acad Sci USA 81: 7713–7717
Alemà S, Casalbore P, Agostini E, Tatò F (1985) Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene. Nature 316: 557–559
Aletta JM, Greene LA (1988) Growth cone configuration and advance: a time-lapse study using video-enhanced differential interference contrast microscopy. J Neurosci 8: 1425–1435
Aletta JM, Lewis SA, Cowan NJ, Greene LA (1988a) Nerve growth factor regulates both the phosphorylation and steady-state levels of microtubule-associated protein 1.2 (MAP 1.2). J Cell Biol 106: 1573–1581
Aletta JM, Angeletti R, Liem RK, Purcell C, Shelanski ML, Greene LA (1988b) Relationship between the nerve growth factor-regulated clone 73 gene product and the 58-kilodalton neuronal intermediate filament protein (peripherin). J Neurochem 51: 1317–1320
Aletta JM, Shelanski ML, Greene LA (1989) Phosphorylation of the peripherin 58-kDa neuronal intermediate filament protein. Regulation by nerve growth factor and other agents. J Biol Chem 264: 4619–4627
Allen JM, Tischler AS, Lee YC, Bloom SR (1984) Neuropeptide Y (NPY) in PC12 phaeochromocytoma cultures: responses to dexamethasone and nerve growth factor. Neurosci Lett 46: 291–296
Anderson DJ, Axel R (1985) Molecular probes for the development and plasticity of neural crest derivatives. Cell 42: 649–662
Andreasen TJ, Luetje CW, Heideman W, Storm DR (1983) Purification of a novel calmodulin binding protein from bovine cerebral cortex membranes. Biochemistry 22: 4615–4618
Andres RY, Jeng I, Bradshaw RA (1977) Nerve growth factor receptors: identificition of distinct classes in plasma membranes and nuclei of embryonic dorsal root neurons. Proc Nati Acad Sci USA 74: 2785–2789
Bar-Sagi D, Feramisco JR (1985) Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42: 841–848
Bar-Sagi D, Feramisco JR (1986) Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. Science 233: 1061–1068
Barbacid M (1987) ras Genes. Annu Rev Biochem 56: 779–827
Bartel DP, Sheng M, Lau LF, Greenberg ME (1989) Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction. Genes Dev 3: 304–313
Biocca S, Cattaneo A, Calissano P (1984) Nerve growth factor inhibits the synthesis of a single-stranded DNA binding protein in pheochromocytoma cells (clone PC12). Proc Natl Acad Sci USA 81: 2080–2084
Black MM, Keyser P (1987) Acetylation of alpha-tubulin in cultured neurons and the induction of alpha-tubulin acetylation in PC12 cells by treatment with nerve growth factor. J Neurosci 7: 1833–1842
Black MM, Aletta JM, Greene LA (1986) Regulation of microtubule composition and stability during nerve growth factor-promoted neurite outgrowth. J Cell Biol 103: 545–557
Blenis J, Erikson RL (1986) Regulation of protein kinase activities in PC12 pheochromocytoma cells. EMBO J 5: 3441–3447
Bothwell MA, Schechter AL, Vaughn KM (1980) Clonal variants of PC12 pheochromocytoma cells with altered response to nerve growth factor. Cell 21: 857–866
Brugg B, Matus A (1988) PC12 cells express juvenile microtubule-associated proteins during nerve growth factor-induced neurite outgrowth. J Cell Biol 107: 643–650
Burridge K, Fath K, Kelly T, Nuckolls G, Turner C (1988) Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu Rev Cell Biol 4: 487–525
Burstein DE, Seeley PJ, Greene LA (1985) Lithium ion inhibits nerve growth factor-induced neurite outgrowth and phosphorylation of nerve growth factor-modulated microtubule-associated proteins. J Cell Biol 101: 862–870
Calissano P, Volonte C, Biocca S, Cattaneo A (1985) Synthesis and content of a DNA-binding protein with lactic dehydrogenase activity are reduced by nerve growth factor in the neoplastic cell line PC12. Exp Cell Res 161: 117–129
Campenot RB (1977). Local control of neurite development by nerve growth factor. Proc Natl Acad Sci USA 74: 4516–4519
Chan BL, Chao MV, Saltiel AR (1989) Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation. Proc Natl Acad Sci USA 86: 1756–1760
Chandler CE, Herschman HR (1980) Tumor promoter modulation of epidermal growth factor-and nerve growth factor-induced adhesion and growth factor binding of PC-12 pheochromocytoma cells. J Cell Physiol 105: 275–285
Chang S, Rathjen FG, Raper JA (1987) Extension of neurites on axons is impaired by antibodies against specific neural cell surface glycoproteins. J Cell Biol 104: 355–362
Chiu AY, Matthew WD, Patterson PH (1986) A monoclonal antibody that blocks the activity of a neurite regeneration-promoting factor: studies on the binding site and its localization in vivo. J Cell Biol 103: 1383–1398
Cho KO, Skarnes WC, Minsk B, Palmieri S, Jackson-Grusby L, Wagner JA (1989) Nerve growth factor regulates gene expression by several distinct mechanisms. Mol Cell Biol 9: 135–143
Cimier BM, Giebelhaus DH, Wakim BT, Storm DR, Moon RT (1987) Characterization of murine cDNAs encoding P-57, a neural-specific calmodulin-binding protein. J Biol Chem 262: 12158–12163
Cochran BH, Reffel AC, Stiles CD (1983) Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell 333: 939–947
Comb M, Birnberg NC, Seasholtz A, Herbert E, Goodman HM (1986) A cyclic AMP- and phorbol ester-inducible DNA element. Nature 323: 353–356
Contreras ML, Guroff G (1987) Calcium-dependent nerve growth factor-stimulated hydrolysis of phosphoinositides in PC12 cells. J Neurochem 48: 1466–1472
Cooperman SS, Grubman SA, Barchi RL, Goodman RH, Mandel G (1987) Modulation of sodiumchannel mRNA levels in rat skeletal muscle. Proc Natl Acad Sci USA 84: 8721–8725
Cremins J, Wagner JA, Halegoua S (1986) Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases. J Cell Biol 103: 887–893
Curran T (1988) Thefos oncogene. In: Reddy EP, Skalka AM (eds) The oncogene handbook. Elsevier, Amsterdam, pp 307–325
Curran T, Morgan JI (1986) Barium modulates c-fos expression and post-translational modification. Proc Nati Acad Sci USA 83: 8521–8524
DeGeorge JJ, Walenga R, Carbonetto S (1988) Nerve growth factor rapidly stimulates arachidonate metabolism in PC12 cells: potential involvement in nerve fiber growth. J Neurosci Res 21: 323–332
Dichter MA, Tischler AS, Greene LA (1977) Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line. Nature 268: 501–504
Dickson G, Prentice H, Julien J-P, Ferrari G, Leon A, Walsh FS (1986) Nerve growth factor activates Thy-1 and neurofilament gene transcription in rat PC12 cells. EMBO J 5: 3449–3453
Doherty P, Walsh FS (1987) Control of Thy-1 glycoprotein expression in cultures of PC12 cells. J Neurochem 49: 610–616
Domenico Borasio G, John J, Wittinghofer A, Barde Y-A, Sendtner M, Heumann R (1989) ras p21 Protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron 2: 1087–1096
Drubin D, Kobayashi S, Kellogg D, Kirschner M (1988) Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells. J Cell Biol 106: 1583–1591
Drubin DG, Feinstein SC, Shooter EM, Kirschner MW (1985) Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. J Cell Biol 101: 1799–1807
Ellis C, Moran M, McCormick F, Pawson T (1990) Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature 343: 377–381
End D, Hanson M, Hashimoto S, Guroff G (1982) Inhibition of the phosphorylation of a 100000 dalton soluble protein in whole cells and cell-free extracts of PC12 pheochromocytoma cells following treatment with nerve growth factor. J Biol Chem 257: 9223–9225
End D, Tolson N, Hashimoto S, Guroff G (1983) Nerve growth factor-induced decrease in the cell-free phosphorylation of a soluble protein in PC12 cells. J Biol Chem 258: 6549–6555
Federoff HJ, Grabczyk E, Fishman MC (1988) Dual regulation of GAP-43 gene expression by nerve growth factor and glucocorticoids. J Biol Chem 263: 19290–19295
Feig LA, Cooper GM (1988) Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol 8: 3235–3243
Femyhough P, Ishii DN (1987) Nerve growth factor modulates tubulin transcript levels in pheochromocytoma PC12 cells. Neurochem Res 12: 891–899
Ferrari G, Greene LA (1985) Does phospholipid methylation play a role in the primary mechanism of action of nerve growth factor. J Neurochem 45: 853–859
Ferrari S, Calabretta B, DeRiel JK, Battini R, Ghezzo F, Lauret E, Griffin C, Emanuel BS, Gurrieri F, Baserga R (1987) Structural and functional analysis of a growth-regulated gene, the human calcyclin. J Biol Chem 262: 8325–8332
Fisch TM, Prywes R, Simon MC, Roeder RG (1989) Multiple sequence elements in the c-fos promoter mediate induction by cAMP. Genes Dev 3: 198–211
Fleischman LF, Chahwala SB, Cantley L (1986) ras-Transformed cells: altered levels of phosphatidylinositol-4, 5-bisphosphate and catabolites. Science 231: 407–410
Franza BR Jr, Sambucetti LC, Cohen DR, Curran T (1987) Analysis of fos protein complexes and fosrelated antigens by high-resolution two-dimensional gel electrophoresis. Oncogene 1: 213–221
Franza BR Jr, Rauscher FJ III, Josephs SF, Curran T (1988) The fos complex and fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science 239: 1150–1153
Frazier WA, Ohlendorf CE, Boyd LF, Aloe L, Johnson EM, Ferrendelli JA, Bradshaw RA (1973) Mechanism of action of nerve growth factor and cyclic AMP on neurite outgrowth in embryonic chick sensory ganglia: demonstration of independent pathways of stimulation. Proc Natl Acad Sci USA 70: 2448–2452
Fujii DK, Massoglia SL, Savion N, Gospodarowicz D (1982) Neurite outgrowth and protein synthesis by PC12 cells as a function of substratum and nerve growth factor. J Neurosci 2: 1157–1175
Fujii M, Shalloway D, Verma IM (1989) Gene regulation by tyrosine kinases: src protein activates various promoters, including c-fos. Mol Cell Biol 9: 2493–2499
Garber SS, Hoshi T, Aldrich RW (1989) Regulation of ionic currents in pheochromocytoma cells by nerve growth factor and dexamethasone. J Neurosci 9: 3976–3987
Garrels JI, Schubert D (1979) Modulation of protein synthesis by nerve growth factor. J Biol Chem 254: 7978–7985
Gilman AG (1984) G proteins and dual control of adenylate cyclase. Cell 36: 577–579
Goelet P, Castellucci VF, Schacher S, Kandel ER (1986) The long and the short of long-term memory—a molecular framework. Nature 322: 419–422
Goldberg DJ, Burmeister DW (1986) Stages in axon formation: observations of growth of Aplysia axons in culture using video-enhanced contrast-differential interference contrast microscopy. J Cell Biol 103: 1921–1931
Goldstein ME, Sternberger NH, Sternberger LA (1987) Phosphorylation protects neurofilaments against proteolysis. J Neuroimmunol 14: 149–160
Goodman R, Herschman HR (1978) Nerve growth factor-mediated induction of tyrosine hydroxylase in a clonal pheochromocytoma cell line. Proc Natl Acad Sci USA 75: 4587–4590
Greenberg ME, Ziff EB (1984) Stimulation of 3T3 cells induces transcription of the c-fos protooncogene. Nature 311: 433–438
Greenberg ME, Greene LA, Ziff EB (1985) Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem 260: 14101–14110
Greene LA, Rein G (1977) Synthesis, Storage and release of acetylcholine by a noradrenergic pheochromocytoma cell line. Nature 268: 349–351
Greene LA, Shooter EM (1980) The nerve growth factor: biochemistry, synthesis, and mechanism of action. Annu Rev Neurosci 3: 353–402
Greene LA, Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73: 2424–2428
Greene LA, Tischler AS (1982) PC12 pheochromocytoma cultures in neurobiological research. Adv Cell Neurobiol 3: 373–414
Greene LA, Burstein DE, Black MM (1982) The role of transcription-dependent priming in nerve growth factor promoted neurite outgrowth. Dev Biol 91: 305–316
Greene LA, Liem RK, Shelanski ML (1983) Regulation of a high molecular weight inicrotubuleassociated protein in PC12 cells by nerve growth factor. J Cell Biol 96: 76–83
Guerrero I, Wong H, Pellicer A, Burstein DE (1986) Activated N-ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells. J Cell Physiol 129: 71–76
Guerrero I, Pellicer A, Burstein DE (1988) Dissociation of c fos from ODC expression and neuronal differentiation in a PC12 subline stably transfected with an inducible N-ras oncogene. Biochem Biophys Res Commun 150: 1185–1192
Gunning PW, Landreth GE, Bothwell MA, Shooter EM (1981) Differential and synergistic actions of nerve growth factor and cyclic AMP in PC12 cells. J Cell Biol 89: 240–245
Hagag N, Halegoua S, Viola M (1986) Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21. Nature 319: 680–682
Halegoua S (1987) Changes in the phosphorylation and distribution of vinculin during nerve growth factor induced neurite outgrowth. Dev Biol 121: 97–104
Halegoua S, Patrick J (1980) Nerve growth factor mediates phosphorylation of specific proteins. Cell 22: 571–581
Hall FL, Fernyhough P, Ishii DN, Vulliet PR (1988) Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C. J Biol Chem 263: 4460–4466
Hama T, Guroff G (1985) Distribution of Nsp 100 and Nsp 100 kinase, a nerve growth factor-sensitive phosphorylation system, in rat tissues. J Neurochem 45: 1279–1287
Hama T, Huang KP, Guroff G (1986) Protein kinase C as a component of a nerve growth factor- sensitive phoophorylation system in PC12 cells. Proc Natl Acad Sci USA 83: 2353–2357
Hashimoto S (1988) K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells. J Cell Biol 107: 1531–1539
Hashimoto S, Iwasaki C, Kuzuya H, Guroff G (1986) Regulation of nerve growth factor action on Nsp100 phosphorylation in PC12h cells by calcium. J Neurochem 46: 1599–1604
Hatanaka H (1981) Nerve growth factor-mediated stimulation of tyrosine hydroxylase activity in a clonal rat pheochromocytoma cell line. Brain Res 222: 225–233
Hatanaka H, Arimatsu Y (1984) Monoclonal antibodies to tyrosine hydroxylase from rat pheochromocytoma PC12h cells with special reference to nerve growth factor-mediated increase of the immunoprecipitable enzymes. Neurosci Res 1: 253–263
Hatanaka H, Otten U, Thoenen H (1978) Nerve growth factor-mediated selective induction of ornithine decarboxylase in rat pheochromocytoma; a cyclic AMP-independent process. FEBS Lett 92: 313–316
Hayes TE, Kitchen AM, Cochran BH (1987) Inducible binding of a factor to the c-fos regulatory region. Proc Natl Acad Sci USA 84: 1272–1276
Holt JT, Gopal TV, Moulton AD, Nienhuis AW (1986) Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc Natl Acad Sci USA 83: 4794–4798
Huff KR, Guroff G (1979) Nerve growth factor-induced reduction of epidermal growth factor responsiveness and epidermal growth factor receptors in PC12 cells: an aspect of cell differentiation. Biochem Biophys Res Commun 89: 175–180
Improta T, Salvatore AM, Di Luzio A, Romeo G, Coccia EM, Calissano P (1988) IFN-gamma facilitates NGF-induced neuronal differentiation in PC12 cells. Exp Cell Res 179: 1–9
Inoue N, Hatanaka H (1982) Nerve growth factor induces specific enkephalin binding sites in a nerve cell line. J Biol Chem 257: 9238–9241
Inoue N, Matsui H, Hatanaka H (1988) Nerve growth factor induces Nat, K — ATPase in a nerve cell line. J Neurochem 50: 230–236
Jacobs JR, Stevens JK (1986) Changes in the organization of the neuritic cytoskeleton during nerve growth factor-activated differentiation of PC12 cells: a serial electron microscopic study of the development and control of neurite shape. J Cell Biol 103: 895–906
Jessell TM (1988) Adhesion molecules and the hierarchy of neural development. Neuron 1: 3–13 Johnson EM Jr, Taniuchi M, Clark HB, Springer JE, Koh S, Tayrien MW, Loy R (1987)
Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system. J Neurosci 7: 923–929
Jumblatt JE, Tischler AS (1982) Regulation of muscarinic ligand binding sites by nerve growth factor in PC12 phaeochromocytoma cells. Nature 297: 152–154
Jumblatt JE, Tischler AS (1982) Regulation of muscarinic ligand binding sites by nerve growth factor in PC12 phaeochromocytoma cells. Nature 297: 152–154
Kerr LD, Holt JT, Matrisian LM (1988) Growth factors regulate transin gene expression by c-fosdependent and c-fos-independent pathways. Science 242: 1424–1427
Koizumi S, Contreras ML, Matsuda Y, Hama T, Lazarovici P, Guroff G (1988) K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells. J Neurosci 8: 715–721
Kruijer W, Schubert D, Verma IM (1985) Induction of the proto-oncogenefos by nerve growth factor. Proc Natl Acad Sci USA 82: 7330–7334
Kujubu DA, Lim RW, Varnum BC, Herschman HR (1987) Induction of transiently expressed genes in PC-12 pheochromocytoma cells. Oncogene 1: 257–262
Lacal JC, Moscat J, Aaronson SA (1987) Novel source of 1,2-diacylglycerol elevated in cells transformed Ha-ras oncogene. Nature 330: 269–272
Lagenaur C, Lemmon V (1987) An Ll-like molecule, the 8D9 antigen, is a potent substrate for neurite extension. Proc Natl Acad Sci USA 84: 7753–7757
Lakshmanan J (1978) Is there a second messenger for nerve growth factor-induced phosphatidylinositot turnover in rat superior cervical ganglia. Brain Res 157: 173–177
Lakshmanan J (1979) Post-synaptic PI-effect of nerve growth factor in rat superior cervical ganglia. J Neurochem 32: 1599–1601
Lander AD, Tomaselli K, Calof AL, Reichardt LF (1983) Studies on extracellular matrix components that promote neurite outgrowth. Cold Spring Harbor Symp Quant Biol 48: 611–623
Landreth GE, Rieser GD (1985) Nerve growth factor-and epidermal growth factor-stimulated phosphorylation of a PC12 cytoskeletally associated protein in situ. J Cell Biol 100: 677–683
Landreth GE, Williams LK (1987) Nerve growth factor stimulates the phosphorylation of a 250 kDa cytockeletal protein in cell-free extracts of PC12 cells. Neurochem Res 12: 943–950
Lau LF, Nathans D (1985) Identification of a set of genes expressed during the GO/G1 transition of cultured mouse cells. EMBO J 4: 3145–3151
Lazarovici P, Dickens G, Kuzuya H, Guroff G (1987) Long-term, heterologous down-regulation of the epidermal growth factor receptor in PC12 cells by nerve growth factor. J Cell Biol 104: 1611–1621
Lazarovici P, Levi BZ, Lelkes PI, Koizumi S, Fujita K, Matsuda Y, Ozato K, Guroff G (1989) K-252a inhibits the increase in c-fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells. J Neurosci Res 23: 1–8
Lee KY, Seeley PJ, Müller TH, Helmer-Matyjek E, Sabban E, Goldstein M, Greene LA (1985) Regulation of tyrosine hydroxylase phosphorylation in PC12 pheochromocytoma cells by elevated K + and nerve growth factor. Evidence for different mechanisms of action. Mol Pharmacol 28: 220–228
Lee V, Trojanowski JQ, Schlaepfer WW (1982) Induction of neurofilament triplet proteins in PC12 cells by nerve growth factor. Brain Res 238: 169–180
Lee VM (1985) Neurofilament protein abnormalities in PC12 cells: comparison with neurofilament proteins of normal cultured rat sympathetic neurons. J Neurosci 5: 3039–3046
Lee VM, Page C (1984) The dynamics of nerve growth factor-induced neurofilament and vimentin filament expression and organization in PC12 cells. J Neurosci 4: 1705–1714
Leonard DG, Ziff EB, Greene LA (1987) Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells. Mol Cell Biol 7: 3156–3167
Leonard DG, Gorham JD, Cole P, Greene LA, Ziff EB (1988) A nerve growth factor-regulated messenger RNA encodes a new intermediate filament protein. J Cell Biol 106: 181–193
Letoumeau PC (1979) Cell-substratum adhesion of neurite growth cones, and its role in neurite elongation. Exp Cell Res 124: 127–138
Letourneau PC (1981) Immunocytochemical evidence for colocalization in neurite growth cones of actin and myosin and their relationship to cell—substratum adhesions. Dev Biol 85: 113–122
Levi A, Shechter Y, Neufeld EJ, Schlessinger J (1980) Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell line. Proc Natl Acad Sci USA 77: 3469–3473
Levi A, Eldridge JD, Paterson BM (1985) Molecular cloning of a gene sequence regulated by nerve growth factor. Science 229: 393–395
Lewis SA, Sherline P, Cowan NJ (1986) A cloned cDNA encoding MAPl detects a single copy gene in mouse and a brain-abundant RNA whose level decreases during development. J Cell Biol 102: 2106–2114
Lim RW, Vamum BC, Herschman HR (1987) Cloning of tetradecanoyl phorbol ester-induced `primary response’ sequences and their expression it density-arrested Swiss 3T3 cells and a TPA non-proliferative variant. Oncogene 1: 263–270
Lindenbaum MH, Carbonetto S, Mushynski WE (1987) Nerve growth factor enhances the synthesis, phosphorylation, and metabolic stability of neurofilament proteins in PC12 cells. J Biol Chem 262: 605–610
Lindenbaum MH, Carbonetto S, Grosveld F, Flavell D, Mushynski WE (1988) Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells. J Biel Chem 263: 5662–5667
Lucas CA, Czlonkowska A, Kreutzberg GW (1980) Regulation of acetylcholinesterase by nerve growth factor in the pheochromocytoma PC12 cell line. Neurosci Lett 18: 333–337
Machida CM, Rodland KD, Matrisian L, Magun BE, Ciment G (1989) NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells. Neuron 2: 1587–1596
Maher PA (1988) Nerve growth factor induces protein-tyrosine phosphorylation. Proc Natl Acad Sci USA 85: 6788–6791
Maher PA (1989) Role of protein tyrosine phosphorylation in the NGF response. J Neurosci Res 24: 29–37
Makanthappa NK, Patterson PH (1989) Thy-1 dimerization, Thy- 1-derived peptides, and neurite outgrowth. Soc Neurosci Abstr 15: 651 (abstract)
Mandel G, Cooperman SS, Maue RA, Goodman RH, Brehm P (1988) Selective induction of brain type II Na + channels by nerve growth factor. Proc Natl Acad Sci USA 85: 924–928
Margolis RK, Salton SR, Margolis RU (1987) Effects of nerve growth factor-induced differentiation on the heparan sulfate of PC12 pheochromocytoma cells and comparison with developing brain. Arch Biochem Biophys 257: 107–114
Marsh L, Letourneau PC (1984) Growth of neuntes without filopodial or lamellipodial activity in the presence of cytochalasin B.J Cell Biol 99: 2041–2047
Masiakowski P, Shooter EM (1988) Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells. Proc Natl Acad Sci USA 85: 1277–1281
Matsuda Y, Guroff G (1987) Purification and mechanism of activation of a nerve growth factor-sensitive S6 kinase from PC12 cells. J Biol Chem 262: 2832–2844
Matsuda Y, Nakanishi N, Dickens G, Guroff G (1986) A nerve growth factor-sensitive S6 kinase in cell-free extracts from PC12 cells. J Neurochem 47: 1728–1734
Max SR, Schwab M, Dumas M, Thoenen H (1978) Retrograde axonal transport of nerve growth factor in the ciliary ganglion of the chick and the rat. Brain Res 159: 411–415
McGuire JC, Greene LA (1980) Stimulation by nerve growth factor of specific protein synthesis in rat PC12 pheochromocytoma cells. Neuroscience 5: 179–189
McGuire JC, Greene LA, Furano AV (1978) NGF stimulates incorporation of fucose or glucosamine into an external glycoprotein in cultured rat PC12 pheochromocytoma cells. Cell 15: 357–365
McTigue M, Cremins J, Halegoua S (1985) Nerve growth factor and other agents mediate phosphorylation and activation of tyrosine hydroxylase. A convergence of multiple kinase activities. J Biol Chem 260: 9047–9056
Milbrandt J (1987) A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 238: 797–799
Milbrandt J (1988) Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron 1: 183–188
Mitchison T, Kirschner M (1988) Cytoskeletal dynamics and nerve growth. Neuron 1: 761–772
Mitsuka M, Hatanaka H (1984) Increase of carbamylcholine-induced 22Na+ influx into pheochromocytoma PC12h cells by nerve growth factor. Brain Res 314: 255–260
Montminy MR, Sevarino KA, Wagner JA, Mandel G, Goodman RH (1986) Identification of a cyclicAMP-responsive element within the rat somatostatin gene. Proc Natl Acad Sci USA 83: 6682–6686
Morgan JI, Curran T (1986) Role of ion flux in the control of c-fos expression. Nature 322: 552–555
Morgan JI, Curran T (1989) Stimulus-transcription coupling in neurons: role of cellular immediate-early genes. TINS 12: 459–462
Müller R, Bravo R, Burckhardt J, Curran T (1984) Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature 312: 716–720
Nakanishi N, Guroff G (1985) Nerve growth factor-induced inccrease in the cell-free phosphorylation of a nuclear protein in PC12 cells. J Biol Chem 260: 7791–7799
Naoi M, Shibahara K, Suzuki H, Nagatsu T (1988) Specific binding of glycosylated betagalactosidase to rat clonal pheochromocytoma PC12h cells: effects of nerve growth factor and gangliosides. J Neurochem 50: 1297–1301
Narumi S, Fujita T (1978) Stimulatory effects of substance P and nerve growth factor ( NGF) on neurite outgrowth in embryonic chick dorsal root ganglia. Neuropharmacology 17: 73–76
Neer EJ, Clapham DE (1988) Roles of G protein subunits in transmembrane signalling. Nature 333: 129–134
Nikodijevic B, Nikodijevic O, Yu MY, Pollard H, Guroff G (1975) The effect of nerve growth factor on cycle AMP levels in superior cerival ganglia of the rat. Proc Natl Acad Sci USA 72: 4769–4771
Nishikura K, Murray JM (1987) Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells. Mol Cell Biol 7: 639–649
Noda M, Ko M, Ogura A, Liu DG, Amano T, Takano T, Ikawa Y (1985) Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature 318: 73–75
O’Lague PH, Huttner SL (1980) Physiological and morphological studies of rat pheochromocytoma cells (PC12) chemically fused and grown in culture. Proc Natl Acad Sci USA 77: 1701–1705
Okabe S, Hirokawa N (1988) Microtubule dynamics in nerve cells: analysis using microinjection of biotinylated tubulin into PC12 cells. J Cell Biol 107: 651–664
Pandiella-Alonso A, Malgaroli A, Vicentini LM, Meldolesi J (1986) Early rise of cytosolic Ca’ induced by NGF in PC12 and chromaffin cells. FEBS Lett 208: 48–51
Parysek LM, Goldman RD (1987) Characterization of intermediate filaments in PC12 cells. J Neurosci 7: 781–791
Pfenninger KH, Johnson MP (1981) Nerve growth factor stimulates phospholipid methylation in growing neurites. Proc Natl Acad Sci USA 78: 7797–7800
Portier MM, Croizat B, Gros F (1982) A sequence of changes in cytoskeletal components during neuroblastoma differentiation. FEBS Lett 146: 283–288
Portier MM, Brachet P, Croizat B, Gros F (1983) Regulation of peripherin in mouse neuroblastoma and rat PC12 pheochromocytoma cell lines. Devi Neurosci 6: 215–226
Possenti R, Eldridge JD, Paterson BM, Grasso A, Levi A (1989) A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway. EMBO J 8: 2217–2223
Prentice HM, Moore SE, Dickson JG, Doherty P, Walsh FS (1987) Nerve growth factor-induced changes in neural cell adhesion molecule (N-CAM) in PC12 cells. EMBO J 6: 1859–1863
Race HM, Wagner JA (1985) Nerve growth factor affects cyclic AMP metabolism, but not by directly stimulating adenylate cyclase activity. J Neurochem 44: 1588–1592
Rausch DM, Dickens G, Doll S, Fujita K, Koizumi S, Rudkin BB, Tocco M, Eiden LE, Guroff G (1989) Differentiation of PC12 cells with v-src: comparison with nerve growth factor. J Neurosci Res 24: 49–58
Reinhold DS, Neet KE (1989) The lack of a role for protein kinase C in neurite extension and in the induction of ornithine decarboxylase by nerve growth factor in PC12 cells. J Biol Chem 264: 3538–3544
Riabowol KT, Vosatka RJ, Ziff EB, Lamb NJ, Feramisco JR (1988) Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells. Mol Cell Biol 8: 1670–1676
Richter-Landsberg C, Jastorff B (1986) The role of cAMP in nerve growth factor-promoted neurite outgrowth in PC12 cells. J Cell Biol 102: 821–829
Richter-Landsberg C, Greene LA, Shelanski ML (1985) Cell surface Thy-1 -cross-reactive glycoprotein in cultured PC12 cells: modulation by nerve growth factor and association with the cytoskeleton. J Neurosci 5: 468–476
Rieger F, Shelanski ML, Greene LA (1980) The effects of nerve growth factor on acetylcholinesterase and its multiple forms in cultures of rat PC12 pheochromocytoma cells: increased total specific activity and appearance of the 16S molecular form. Dev Biol 76: 238–243
Romano C, Nichols RA, Greengard P (1987) Synapsin I in PC12 cells. II. Evidence for regulation by NGF of phosphorylation at a novel site. J Neurosci 7: 1300–1306
Rowland EA, Müller TH, Goldstein M, Greene LA (1987) Cell-free detection and characterization of a novel nerve growth factor-activated protein kinase in PC12 cells. J Biol Chem 262: 7504–7513
Rudy B, Kirschenbaum B, Rukenstein A, Greene LA (1987) Nerve growth factor increases the number of functional Na channels and induces TTX-resistant Na channels in PC12 pheochromocytoma cells. J Neurosci 7: 1613–1625
Rutishauser U, Jessell TM (1988) Cell adhesion molecules in vertebrate neural development. Physiol Rev 68: 819–857
Rydel RE, Greene LA (1987) Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells. J Neurosci 7: 3639–3653
Saarma M, Toots U, Raukas E, Zhelkovsky A, Pivazian A, Neuman T (1986) Nerve growth factor induces changes in (2’-5’)oligo(A) synthetase and 2’-phosphodiesterase activities during differentiation of PC12 pheochromocytoma cells. Exp Cell Res 166: 229–236
Sajovic P, Ennulat DJ, Shelanski ML, Greene LA (1987) Isolation of NILE glycoprotein-related eDNA probes. J Neurochem 49: 756–763
Saltiel AR, Cuatrecasas P (1988) In search of a second messenger for insulin. Am J Physiol 255: Cl-C11
Sano K, Kikuchi A, Matsui Y, Teranishi Y, Takai Y (1989) Tissue-specific expression of a novel GTPbinding protein (smg p25A) mRNA and its increase by nerve growth factor and cyclic AMP in rat pheochromocytoma PC-12 cells. Biochem Biophys Res Commun 158: 377–385
Sassone-Corsi P, Visvader J, Ferland L, Mellon PL, Verma IM (1988) Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element. Genes Dev 2: 1529–1538
Sassone-Corsi P, Der CJ, Verma IM (1989) ras-Induced neuronal differentiation of PC12 cells: possible involvement of fos and jun. Mol Cell Biol 9: 3174–3183
Schonthal A, Herrlich P, Rahmsdorf HJ, Ponta H (1988) Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell 54: 325–334
Schubert D, Whitlock C (1977) Alteration of cellular adhesion by nerve growth factor. Proc Natl Acad Sci USA 74: 4055–4058
Schubert D, Heinemann S, Kidokoro Y (1977) Cholinergic metabolism and synapse formation by a rat nerve cell line. Proc Natl Acad Sci USA 74: 2579–2583
Schubert D, LaCorbiere M, Whitlock C, Stallcup W (1978) Alterations in the surface properties of cells responsive to nerve growth factor. Nature 273: 718–723
Schubert D, Jin L-W, Saitoh T, Cole G (1989) The regulation of amyloid ß protein precursor secretion and its modulatory role in cell adhesion. Neuron 3: 689–694
Schwarz MA, Brown N, Eveleth DD, Bradshaw RA (1989) Modulation of growth factor induced fiber outgrowth in rat pheochromocytoma (PC12) cells by a fibronectin receptor antibody. J Cell Physiol 138: 121–128
Seeley PJ, Rukenstein A, Connolly JL, Greene LA (1984) Differential inhibition of nerve growth factor and epidermal growth factor effects on the PC12 pheochromocytoma line. J Cell Biol 98: 417–426
Sheng M, Dougan ST, McFadden G, Greenberg ME (1988) Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences. Mol Cell Biol 8: 2787–2796
Shibanuma M, Kuroki T, Nose K (1987) Inhibition of proto-oncogene c-fos transcription by inhibitors of protein kinase C and ion transport. Eur J Biochem 164: 15–19
Skaper SD, Varon S (1984) Nerve growth factor stimulates phospholipid methylation in target ganglionic neurons independently of the cyclic AMP and sodium pump responses. J Neurochem 42: 116–122
Skaper SD, Bottenstein JE, Varon S (1979) Effects of nerve growth factor on cyclic AMP levels in embryonic chick dorsal root ganglia following factor deprivation. J Neurochem 32: 1845–1851
Skene JH (1989) Axonal growth-associated proteins. Annu Rev Neurosci 12: 127–156
Smith SJ (1988) Neuronal cytomechanics: the actin-based motility of growth cones. Science 242: 708–715
Smith MR, DeGudicibus SJ, Stacey DW (1986) Requirement for c-ras proteins during viral oncogene transformation. Nature 320: 540–543
Smith DS, King CS, Pearson E, Gittinger CK, Landreth GE (1989) Selective inhibition of nerve growth factor-stimulated protein kinases by K-252a and 5’-S-methyladenosine in PC12 cells. J Neurochem 53: 800–806
Sobue K, Kanda K (1988) Localization of pp60“” in growth cone of PC12 cell. Biochem Biophys Res Commun 157: 1383–1389
Sonnenberg JL, Rauscher FJ III, Morgan JI, Curran T (1989) Regulation of proenkephalin by fos and jun. Science 246: 1622–1625
Stacey DW, Watson T, Kung HF, Curran T (1987) Microinjection of transforming ras protein induces c-fos expression. Mol Cell Biol 7: 523–527
Stallcup WB, Beasley L (1985) Involvement of the nerve growth factor-inducible large external glycoprotein ( NILE) in neurite fasciculation in primary cultures of rat brain. Proc Natl Acad Sci USA 82: 1276–1280
Stein R, Orit S, Anderson DJ (1988) The induction of a neural-specific gene, SCGIO, by nerve growth factor in PC12 cells is transcriptional, protein synthesis dependent, and glucocorticoid inhibitable. Dev Biol 127: 316–325
Strassman RJ, Letoumeau PC, Wessells NK (1973) Elongation of axons in an agar matrix that does not support cell locomotion. Exp Cell Res 81: 482–487
Sugimoto Y, Noda M, Kitayama H, Ikawa Y (1988) Possible involvement of two signaling pathways in induction of neuron-associated properties by v-Ha-ras gene in PC12 cells. J Biol Chem 263: 12102–12108
Takahashi M, Tsukui H, Hatanaka H (1985) Neuronal differentiation of Ca’ channel by nerve growth factor. Brain Res 341: 381–384
Taniguchi T, Morisawa K, Ogawa M, Yamamoto H, Fujimoto S (1988) Decrease in the level of poly(ADP-ribose) synthetase during nerve growth factor-promoted neurite outgrowth in rat pheochromocytoma PC12 cells. Biochem Biophys Res Commun 154: 1034–1040
Thoenen H, Angeletti PU, Levi-Montalcini R, Kettler R (1971) Selective induction by nerve growth factor of tyrosine hydroxylase and dopamine-hydroxylase in the rat superior cervical ganglia. Proc Natl Acad Sci USA 68: 1598–1602
Thompson MA, Ziff EB (1989) Structure of the gene encoding peripherin, an NGF-regulated neuronal-specific type III intermediate filament protein. Neuron 2: 1043–1053
Tiercy JM, Shooter EM (1986) Early changes in the synthesis of nuclear and cytoplasmic proteins are induced by nerve growth factor in differentiating rate PC12 cells. J Cell Biol 103: 2367–2378
Tirone F, Shooter EM (1989) Early gene regulation by nerve growth factor in PC12 cells: induction of an interferon-related gene. Proc Natl Acad Sci USA 86: 2088–2092
Tischler AS, Lee YC, Slayton VW, Bloom SR (1982) Content and release of neurotensin in PC12 pheochromocytoma cell cultures: modulation by dexamethasone and nerve growth factor. Regul Pept 3: 415–421
Toda T, Uno I, Ishikawa T, Powers S, Kataoka T, Broek D, Cameron S, Broach J, Matsumoto K, Wigler M (1985) In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 40: 2736
Togari A, Guroff G (1985) Partial purification and characterization of a nerve growth factor-sensitive kinase and its substrate from PC12 cells. J Biol Chem 260: 3804–3811
Togari A, Dickens G, Kuzuya H, Guroff G (1985) The effect of fibroblast growth factor on PC12 cells. J Neurosci 5: 307–316
Traynor AE (1984) The relationship between neurite extension and phospholipid metabolism in PC12 cells. Brain Res 316: 205–210
Traynor AE, Schubert D, Allen WR (1982) Alterations of lipid metabolism in response to nerve growth factor. J Neurochem 39: 1677–1683
Treisman R (1985) Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5’ element and c-fos 3’ sequences. Cell 42: 889–902
Turner DC, Flier LA, Carbonetto S (1989) Identification of a cell-surface protein involved in PC12 cell-substratum adhesion and neurite outgrowth on laminin and collagen. J Neurosci 9: 3287–3296
Van Hooff CO, De Graan PN, Oestreicher AB, Gispen WH (1988) B-50 phosphorylation and polyphosphoinositide metabolism in nerve growth cone membranes. J Neurosci 8: 1789–1795
Van Hooff CO, Holthuis JC, Oestreicher AB, Boonstra J, De Graan PN, Gispen WH (1989) Nerve growth factor-induced changes in the intracellular localization of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells. J Cell Biol 108: 1115–1125
Vinores SA, Marangos PJ, Parma AM, Guroff G (1981) Increased levels of neuron-specific enolase in PC12 pheochromocytoma cells as a result of nerve growth factor treatment. J Neurochem 37: 597–600
Visvader J, Sassone-Corsi P, Verma IM (1988) Two adjacent promoter elements mediate nerve growth factor activation of the c-fos gene and bind distinct nuclear complexes. Proc Natl Acad Sci USA 85: 9474–9478
Volonte C, Rukenstein A, Loeb DM, Greene LA (1989) Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase. J Cell Biol 109: 2395–2403
Wu BY, Fodor EJ, Edwards RH, Rutter WJ (1989) Nerve growth factor induces the proto-oncogene c-jun in PC12 cells. J Biol Chem 264: 9000–9003
Yamamoto KR, Alberts BM (1976) Steroid receptors: elements for modulation of eukaryotic transcription. Annu Rev Biochem 45: 721–746
Yankner BA, Shooter EM (1979) Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane. Proc Natl Acad Sci USA 76: 1269–1273
Young S, Parker PJ, Ullrich A, Stabel S (1987) Down-regulation of protein kinase C is due to an increased rate of degradation. Biochem J 244: 775–779
Yu CL, Tsai MH, Stacey DW (1988) Cellular ras activity and phospholipid metabolism. Cell 52: 6371
Yu MW, Tolson NW, Guroff G (1980) Increased phosphorylation of specific nuclear proteins in superior cervical ganglia and PC12 cells in response to nerve growth factor. J Biol Chem 255: 10481–10492
Zigmond RE, Schwarzschild MA, Rittenhouse AR (1989) Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation. Annu Rev Neurosci 12: 415–461
Zuber MX, Goodman DW, Karns LR, Fishman MC (1989) The neuronal growth-associated protein GAP-43 induces filopodia in non-neuronal cells. Science 244: 1193–1195
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Halegoua, S., Armstrong, R.C., Kremer, N.E. (1991). Dissecting the Mode of Action of a Neuronal Growth Factor. In: Bothwell, M. (eds) Neuronal Growth Factors. Current Topics in Microbiology and Immunology, vol 165. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75747-1_7
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