Neuronal Growth Factors

  • Mark Bothwell

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 165)

Table of contents

  1. Front Matter
    Pages I-IX
  2. F. H. Gage, M. H. Tuszynski, K. S. Chen, A. M. Fagan, G. A. Higgins
    Pages 71-93
  3. S. Halegoua, R. C. Armstrong, N. E. Kremer
    Pages 119-170
  4. Back Matter
    Pages 171-176

About this book

Introduction

A host of environmental factors regulate the embryonic development of neurons. In adults, the survival of neurons, the regeneration of damaged axons, and plastic changes in axonal arborization are also controlled by a complex array of environmental cues. An important category of regulatory influences involves target-derived hormone-like peptides act­ ing on neuronal cell surface receptors. Nerve growth factor (NGF) was the first such factor to be characterized (LEVI­ MONTALCINI and HAMBURGER 1953) and has served as the model against which all similar factors are compared. A number of factors with properties similar to NGF have been described with activities toward differing populations of neurons. Many of these factors have been characterized only poorly at the biochemical level. However, several factors have been charac­ terized to the extent that molecular clones are available and complete amino acid sequences are known. These include: three structurally related factors, NGF itself (SCOTT et al. 1983), brain-derived neurotrophic factor (BDNF) (LEIBROCK et al. 1989), and neurotrophin-3 (NT-3) (MAISONPIERRE et al. 1990; HOHN et al. 1990); ciliary neurotrophic factor (CNTF) (LIN et al. 1989) and a second set of structural homologs; acidic and basic fibroblast growth factors (aFGF, bFGF) (ABRAHAM et al. 1986; JAYE et al. 1986). Investigators have cloned the receptors for NGF (JOHNSON et al. 1986; RADEKE et al. 1987) and FGF (LEE et al. 1989).

Keywords

Alzheimer Nervous System Wachstum Wachstumsfaktor Wachstumsfaktoren alzheimer's disease biochemistry biology cell cell biology diseases neurobiology neurochemistry regulation signal transduction

Editors and affiliations

  • Mark Bothwell
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of WashingtonSeattleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-75747-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-75749-5
  • Online ISBN 978-3-642-75747-1
  • Series Print ISSN 0070-217X
  • About this book