Abstract
The congenital syndrome known as severe combined immune deficiency (SCID) is characterized by a loss of both B and T cell immunity. It was first recognized in human infants (Glanzmann and Riniker 1950; Tobler et al. 1958; Hitzig et al. 1958) and later in Arabian foals (McGuire et al. 1975). More recently, the SCID syndrome was reported in a mutant strain of mice, called scid mice (Bosma et al. 1983). This article briefly reviews the genetics of the murine scid mutation as well as early findings on the effect of scid on the lymphoid system.
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References
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© 1989 Springer-Verlag Berlin · Heidelberg
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Bosma, M.J. (1989). The scid Mutation: Occurrence and Effect. In: Bosma, M.J., Phillips, R.A., Schuler, W. (eds) The Scid Mouse. Current Topics in Microbiology and Immunology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74974-2_1
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DOI: https://doi.org/10.1007/978-3-642-74974-2_1
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