The Scid Mouse

Characterization and Potential Uses

  • Melvin J. Bosma
  • Robert A. Phillips
  • Walter Schuler

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 152)

Table of contents

  1. Front Matter
    Pages I-XII
  2. General Phenotype/Cellular Characterization

    1. Front Matter
      Pages 1-1
    2. Melvin J. Bosma
      Pages 3-9
    3. Sonoko Habu, Yoko Norihisa, Takehito Sato, Hideo Yagita, Ko Okumura
      Pages 27-32
    4. G. Lee, K. Medina, P. W. Kincade
      Pages 33-37
    5. Shin-Ichi Nishikawa, Shin-Ichi Hayashi, Satomi Nishikawa, Minetaro Ogawa, Takahiro Kunisada, Tetsuo Sudo et al.
      Pages 39-46
    6. Vinay Kumar, J. Hackett Jr., M. M. Tutt, B. A. Garni-Wagner, W. A. Kuziel, P. W. Tucker et al.
      Pages 47-52
  3. General Phenotype/Molecular Characterization

    1. Front Matter
      Pages 53-53
    2. Ann M. Carroll, Melvin J. Bosma
      Pages 63-67
    3. Michael R. Lieber, Joanne E. Hesse, Susanna Lewis, Gayle C. Bosma, Naomi Rosenberg, Kiyoshi Mizuuchi et al.
      Pages 69-75
    4. T. Keith Blackwell, Pierre Ferrier, Barbara A. Malynn, Roberta R. Pollock, Lori R. Covey, Heikyung Suh et al.
      Pages 85-94
  4. Introduction of Functional Ig or TCR Transgenes

    1. Front Matter
      Pages 95-95
    2. Harald von Boehmer, Horst Blüthmann, Hung Sia Teh, Bernadette Scott
      Pages 97-105
    3. Michal Fried, Richard R. Hardy, Melvin J. Bosma
      Pages 107-114
  5. Leaky Phenotypes

    1. Front Matter
      Pages 115-115
    2. Ann M. Carroll, Richard R. Hardy, John Petrini, Melvin J. Bosma
      Pages 117-123

About these proceedings

Introduction

During routine genetic screening of several immunoglobulin heavy chain congenic mouse strains in 1980, one of us (MB) was surprised to find that several mice in the C.B-17IIcr strain, which was being maintained in a specific-pathogen-free facility of the Fox Chase Cancer Center (Philadelphia, PA), did not express serum immunoglobulin of the appropriate allotype. Fearing an error in the breeding of these mice, the sera of the suspect mice were screened for other allotypes. When these tests revealed a complete absence of serum immunoglobulin, it became apparent that a mutation had probably occurred in the C.B-17IIcr line. Further analysis revealed that a single breeding pair was respon­ sible for all of the immunoglobulin negative mice and that the defect showed recessive inheritance. Thus was the C.B-17/Icr scid or severe combined immune deficient (scid) mouse discovered. Although it has taken most animal facilities several years to breed scid mice of high quality for experimental purpose, it was clear by 1987 that many investigators were beginning to exploit the unique qualities of the scid mouse for studies in several areas.

Keywords

AIDS Biomedizinische Technik HIV Immunschwäche Leukämie Thymus bone immunobiology tissue transplantation

Editors and affiliations

  • Melvin J. Bosma
    • 1
  • Robert A. Phillips
    • 2
  • Walter Schuler
    • 3
  1. 1.Fox Chase Cancer CenterInstitute for Cancer ResearchPhiladelphiaUSA
  2. 2.Division of Hematology/Oncology, Hospital for Sick Children, Departments of Immunology and GeneticsUniversity of TorontoTorontoCanada
  3. 3.Basel Institute for ImmunologyBaselSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-74974-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1989
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-74976-6
  • Online ISBN 978-3-642-74974-2
  • Series Print ISSN 0070-217X
  • About this book