Abstract
Surgical resection of malignant tissues, radiotherapy, and chemotherapy have developed as the three solid columns for tumor therapy. Despite many improvements and refinements of these therapy modalities, it has proved impossible to develop cures for a great number of individual malignancies, and frequently this is even true of reasonable palliative treatment. Moreover, cancers can frequently develop a high resistance to ionizing radiation or chemotherapeutic drugs. The search for new therapy modalities is necessary in order to overcome such resistance.
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Adam G, Neumann H, Hinkelbein W, Weth R, Engelhardt R (1983) Metabolic changes in hyperthermia with chemotherapy. In: Engelhardt R (ed) Proceedings of the 13th international congress of chemotherapy. Vienna, pp 37–40, session 12.10, part 273
Adwankar MK, Chitnis MP (1984) Effect of hyperthermia alone and in combination with anticancer drugs on the viability of P388 leukemic cells. Tumori 70:231–234
Ahnström G, Edvardsson KA (1974) Radiation-induced single-strand breaks in DNA determined by rate of alkaline strand separation and hydroxylapartite chromatography: an alternative to velociy sedimentation. Int J Radiat Biol 26:493–497
Alper T (1979) Cellular radiobiology. Cambridge University Press, Cambridge
Altman K, Gerber GB, Okada S (1970) Radiation-biochemistry. Academic, New York
Anderson RL, Minton KW, Li GC, Hahn GM (1981) Temperature induced homeoviscous adaptation of Chinese hamster ovary cells. Biochim Biophys Acta 641:334–348
Anderson RL, Ahier RG, Littleton JM (1983) Observations on the cellular effects of ethanol and hyperthermia in vivo. Radiat Res 94:318–325
Anderstam B, Harms-Ringdahl M (1988) Increased antineoplastic activity of combined hyperthermic and bleomycin treatments in an adenocarcinoma after glutathione depletion in vivo. Int J Hyperthermia 4:297–306
Ando K, Urano M, Kenton L, Kahn J (1987) Effect of ther-mochemotherapy on the development of spontaneous lung metastases. Int J Hyperthermia 3:453–458
Anghilari LJ, Crone-Escanye MC, Marchai C, Robert J (1984) Plasma membrane changes during hyperthermia: probable role of ionic modification in tumor cell death. In: Overgaard J (ed) Hyperthermic oncology, vol I, pp 49–52
Ashburner J, Bonner JJ (1979) The induction of gene activity in Drosophila by heat shock. Cell 17:241–254
Atkinson ER (1977) Hyperthermia dose definition. J Bioengineering 1:487–492
Auersperg N (1966) Differential heat sensitivity of cells in tissue culture. Nature 209:415–416
Barlogie B, Corry PM, Drewinko B (1980) In vitro ther-mohemotherapy of human colon cancer cells with cis-dichlorodiammineplatinum (II) and mitomycin C. Cancer Res. 40:1165–1166
Bass H, Moore JL, Coakely WT (1978) Lethality in mammalian cells due to hyperthermia under oxic and hypoxic conditions. Int J Radiat Biol 33:57–67
Belli JA, Bonte FJ (1963) Influence of temperature on the radiation response of mammalian cells in tissue culture. Radiat Res 18:272–276
Belt JA, Thomas JA, Buchsbaum RN, Racker E (1979) Inhibition of lactate transport and glycolysis in Ehrlich ascites tumor cells by bioflavonoids. Biochemistry 18:3506–3511
Ben-Hur E, Riklis E (1979) Enhancement of thermal killing by polyamines, IV. Effects of heat sensitivity and spermine on protein synthesis and ornithine decarboxylase. Cancer Biochem. Biophys. 4:25–31
Ben-Hur E, Bronk VB, Elkind MM (1972) Thermally enhanced radiosensitivity of cultured Chinese hamster cells. Nature 238:209–211
Ben-Hur E, Elkind MM, Bronk BV (1974) Thermally enhanced radioresponse of cultured Chinese hamster cells: inhibition of repair of sublethal damage and enhancement of lethal damage. Radiat Res 58:38–51
Bhuyan BK, Day KJ, Edgerton CE, Ogunbase O (1977) Sensitivity of different cell lines and of different phases in the cell cycle to hyperthermia. Cancer Res 37:3780–3784
Bleehen NM, Honess DJ, Morgan JE (1977) Interaction of hyperthermia and the hypoxic cell sensitizer Ro-07–0582 on the EMT 6 mouse tumor. Brit J Cancer 35:299–306
Boonstra J, Schamhart DHJ, de Laat SW, van Wijk R (1984) Analysis of K+ and Na+ transport and intracellular contents during and after heat shock and their role in protein synthesis in rat hepatoma cells. Cancer Res 44:955–960
Borelli MJ, Wong RSL, Dewey WC (1986) A direct correlation between hyperthermia-induced membrane blebbing and survival in synchronous G1 CHO cells. J Cell Physiol 126:181–190
Bowler K, Duncan CJ, Gladwell RT, Davison TF (1973) Cellular heat injury. Comp Biochem Physiol [A] 45:441–45ß
Braun J, Hahn GM (1975) Enhanced cell killing by bleomycin and 43 °C hyperthermia and the inhibition of recovery from potentially lethal damage. Cancer Res 35:2921–2927
Breasted JH (1930) The Edwin Smith surgical papyrus. In: Licht S (ed) Therapeutic heat and cold, 2nd edn. Waverly, pp 196–211
Breipohl W, van Beuningen D, Ummels M, Streffer C, Schönfelder B (1983) Effect of hyperthermia on the intestinal mucosa of mice. Verh Anat Ges 77:567–569
Britt RH, Lyons BE, Pounds DW, Prionas SD (1983) Feasibility of ultrasound hyperthermia in the treatment of malignant brain tumors. Med Instrum 17:172–177
Bull JM (1983) Systemic hyperthermia: background and principles. In: Storm FK, Hall GK (eds) Hyperthermia in cancer therapy. Medical, Boston, pp 401–405
Burdon RH (1985) Heat shock proteins. In: Overgaard J (ed) Hyperthermic Oncology, vol II. Taylor and Francis, London pp 223–230
Burdon RH (1988) Hyperthermic toxicity and the modulation of heat damage to cell protein synthesis in HeLa cells. Recent Results Cancer Res 109:1–8
Burdon RH, Cutmore CMM (1982) Human heat shock gene expression and the modulation of plasma membrane Na+/K+ ATPase activity. FEBS Lett 140:45–48
Burdon RH, Slater A, McMahon M, Cato ACB (1982) Hyperthermia and heat shock proteins and HeLa cells. Br J Cancer 45:953–963
Burdon RH, Kerr SM, Cutmore CMM, Munro J, Gill V (1984) Hyperthermia, Na+K+ ATPase and lactic acid production in some human tumour cells. Br J Cancer 49:437–445
Burger F, Engelbrecht FW (1967) Changes in blood composition in experimental heat stroke. S Afr Med J 41:718–721
Busch W (1866) Über den Einfluss welche heftigere Erysipeln zuweilig auf organisierte Neubildungen ausüben. Vrh. Natur-hist. Preuss Rhein Westphal 23:28–30
Calderwood SK, Hahn GM (1983) Thermal sensitivity and resistance of insulin-receptor binding. Biochim Biophys Acta 756:1–8
Calderwood SK, Bump EA, Stevenson MA, van Kersen I, Hahn GM (1985) Investigation of adenylate energy charge, phosphorylation potential, and ATP concentration in cell stressed with starvation and heat. J Cell Physiol 124:261 – 268
Cavaliere R, Ciocatto EC, Giovanella BC, Heidelberger C, Johnson RO, Moricca G, Rossi-Fanelli A (1967) Selective heat sensitivity of cancer cells (biochemical and clinical studies). Cancer 20:1351–1381
Chen TT, Heidelberger C (1969) Quantitative studies on the malignant transformation of mouse prostate cells by carcinogenic hydrocarbons in vitro. Int J Cancer 4:166–178
Chlebowski RT, Block JB, Cundiff D, Dietrich MF (1982) Doxorubicin cytotoxicity enhanced by local anaesthetics in a human melanoma cell line. Cancer Treat Rep 66:121–125
Clark EP, Lett JT (1978) Possible mechanisms for hyperthermic inactivation of the rejoining of X-ray induced DNA strand breaks. In: Streffer C, van Beuningen D, Dietzel F, Röttinger E, Robinson JE, Scherer E, Seeber S, Trott K-R (eds) Cancer therapy by hyperthermia and radiation. Proceedings of the 2nd international symposium, Essen, June 2–4 1977. Urban and Schwarzenberg, Baltimore, pp 144–145
Clawson RE, Egorin MJ, Fox BM, Ross LA, Bachur NR (1981) Hyperthermic modification of cyclophosphamide metabolism in rat heptic microsomes and liver slices. Life Sci 28:1133–1137
Cohen GL, Bauer WR, Barton JK et al. (1979) Binding of cis-and trans-dichlorodiamineplatinum (II) to DNA: evidence for unwinding and shortening of the double helix. Science 203:1014–1016
Coley WB (1893) The treatment of malignant tumors by repeated inoculations of erysipelas, with a report of ten original cases. Am J Med Sci 105:488–511
Collins FG, Skibba JL (1979) Effect of hyperthermia and mechlorethamine and hepatic function in isolated perfused liver. Proc Am Assoc Cancer Res 20:125
Collins FG, Skibba JL (1983) Altered hepatic functions and microsomal activity in perfused rat liver by hyperthermia combined with alkylating agents. Cancer Biochem Biophys 6:205–211
Collins FG, Mitros FA, Skibba JL (1980) Effect of palmitate on hepatic biosynthetic functions at hyperthermic temperatures. Metabolism 29:524–531
Connor WG, Gerner EW, Miller RC, Boone MLM (1977) Prospects for hyperthermia in human cancer therapy: part II. Radiology 123:497–503
Corry PM, Robinson S, Getz S (1977) Hyperthermic effects on DNA repair mechanisms. Radiology 123:475–482
Coss RA, Dewey WC (1988) Heat sensitization of G 1 and S phase cells by procaine HCl. II. Toxicity and probability of dividing following treatment. Int J Hyperthermia 4:687–697
Coss RA, Dewey WC, Bamburg JR (1982) Effects of hyperthermia on dividing Chinese hamster ovary cells and on microtubules in vitro. Cancer Res 42:1059–1071
Cress AE, Culver PS, Moon ThE, Gerner EW (1982) Correlation between amounts of cellular membrane components and sensitivity to hyperthermia in a variety of mammalian cell lines in cultures. Cancer Res 42:1716–1721
Crile G (1962) Selective destruction of cancers after exposure to heat. Ann Surg 156:404–407
Crile G (1963) The effects of heat and radiation on cancers implanted into the feet of mice. Cancer Res 23:372–380
Dahl O (1982) Interaction of hyperthermia and doxorubicin on malignant neurogenic rat cell line in (3T4C) in culture. In: Dethlefsen LA, Dewey WC (eds) 3rd international symposium: cancer therapy by hyperthermia, drugs and radiation. NCI Monogr. 61:251–253
Dahl O (1983) Hyperthermic potentiation of doxorubicin and 4-epi-doxorubicin in a transplantable neurogenic rat tumor (BT4A) in BD IX rats. Int J Radiat Oncol Biol Phys 9:203–207
Dahl O, Mella O (1982) Enhanced effect of combined hyperthermia and chemotherapy (Bleomycin, BCNU) in a neurogenic rat tumor (BT4A) in vivo. Anticancer Res 2:359–364
Dahl O, Mella O (1983) Effect of timing and sequence of hyperthermia and cylophosphamide on a neurogenic rat tumor (BT4A) in vivo. Cancer 52:983–987
Dahl O, Mella O (1984) Timing and sequence of hyperthermia and drugs. In: Hyperthermic oncology 1984, vol 1. Proceedings of the 4th international symposium on hyperthermic oncology, Aarhus, 2–6 July 1984, pp 425–438
Daly JM, Smith G, Frazier H, Dudrick SJ, Copeland, EM (1982) Effects of systemic hyperthermia and intrahepatic infusion with 5-fluorouracil. Cancer 49:1112–1115
Dennis WH, Yatvin MB (1981) Correlation of hyperthermic sensitivity and membrane microviscosity in E. coli K1060. Int J Radiat Biol 39:265–271
Dertinger H, Jung H (1970) Molekulare Strahlenbiologie. Springer, Berlin Heidelberg New York
DeSilva V, Tofilon PJ, Gutin PH, Dewey WC, Buckley N, Deen DF (1985) Comparative study of the effects of hyperthermia and BCNU on BCNU-sensitive and BCNU-resistant 9L rat brain tumor cells. Radiat Res 103:363–372
Dethlefsen LA, Dewey WC (1982) Third international symposium: cancer therapy by hyperthermia, drugs, and radiation. N C I Monogr 61
Dewey WC (1984) Interaction of heat with radiation and chemotherapy. Cancer Res [Suppl] 44:4714s-4720s
Dewey WC (1988) Hyperthermic effects studied in vitro. In: Fielden EM, Fowler JF, Hendry JH, Scott D (eds) Radiation research. Taylor and Francis, London, pp 954–959
Dewey WC, Esch JL (1982) Transient thermal tolerance: cell killing and polymerase activities. Radiat Res 92:611–614
Dewey WC, Holohan EV (1984) Hyperthermia — basic biology. In: Rosenblum ML, Wilson CB (eds) Progress in experimental tumor research: brain tumor therapy, vol 28. Karger Medical and Scientific, Basel, pp 198–219
Dewey WC, Lix LC (1988) Cell-cycle effects: killing division delay and chromosomal aberrations. In: 5th international symposium on hyperthermic oncology, Kyoto, p 20 (abstracts)
Dewey WC, Westra A, Miller HH (1971) Heat-induced lethality and chromosomal damage in synchronized Chinese hamster cells treated with 5-bromodeoxyuridine. Int J Radiat Biol 20:505–520
Dewey WC, Hopwood LE, Sapareto SA, Gerweck LE (1977) Cellular responses to combinations of hyperthermia and radiation. Radiology 123:464–477
Dewey WC, Hopwood LE, Sapareto SA, Gerweck LE (1977) Cellular responses to combinations of hyperthermia and radiation. Radiology 123: 497–503
Dewey WC, Sapareto SA, Betten DA (1978) Hyperthermic radiosensitization of synchronous Chinese hamster cells: relationship between lethality and chromosomal aberrations. Radiat Res 76:48–59
Dewey WC, Freeman ML, Raaphorst GP, Clark EP, Wong RSL, Highfield DP, Spiro IJ, Tomasovic SP, Denman DL, Coss RA (1979) Cell biology of hyperthermia and radiation. In: Meyn RE, Withers HR (eds) Radiation biology in cancer research. Williams and Wilkins, Baltimore
Dewey WC, Freeman ML, Raaphorst GP, Clark EP, Wong RS, Highfield DP, Spiro JS, Tomasovic SP, Denman DL, Coss RA (1980) Cell biology of hyperthermia and radiation. In: Meyn RE, Withers HR (eds) Radiation biology in cancer research. Raven, New York, pp 589–623
Dewhirst MW, Sim DA, Sapareto S, Connor WG (1984) Importance of minimum tumor temperature in determining early and long-term responses of camine and fehine tumors to heat and radiation. Cancer Res 44:43–50
Dickson J, Calderwood SK (1979) Effect of hyperglycemia and hyperthermia on the pH, glycolysis and respiration of the Yoshida sarcoma in vivo. J N C I 63:1371–1381
Dietzel F (1975) Tumor and temperature. Urban and Schwarzenberg, München
Dikomey E (1978) Repair of DNA strand breaks in Chinese hamster ovary cells at 37 degrees or at 42 degrees C. In: Streffer C, van Beuningen D, Dietzel F, Röttinger E, Robinson JE, Scherer E, Seeber S, Trott K-R (eds) Cancer therapy by hyperthermia and radiation. Proceedings of the second international symposium, Essen, June 2–4 1977. Urban and Schwarzenberg, Munich, pp 146–149
Dikomey E (1982) Effect of hyperthermia at 42 °C and 45 °C on repair of radiation-induced DNA strand breaks in CHO cells. Int J Radiat Biol 41:603–614
Dikomey E, Franzke J (1986) Three classes of DNA strand breaks induced by X-irradiation and internal β-rays. Int J Radiat Biol 50:893–908
Dikomey E, Jung H (1988) Correlation between polymerase ß activity and thermal radiosensitization in CHO cells. Recent Results Cancer Res 109:35–41
Dube DK, Seal G, Loeb LA (1977) Differential heat sensitivity of mammalian DNA polymerase. Biochem Biophys Res Commun 76:483–487
Durand RE (1978) Potentiation of radiation lethality by hyperthermia in a tumor model: effects of sequence, degree and duration of heating. Int J Radiat Oncol Biol Phys 4:401–406
Eickhoff J, Dikomey E (1984) Development and decay of acutely induced thermotolerance in CHO cells by different heat shocks at various external pH values. In: Overgaard J (ed) Hyperthermic oncology, vol 1. Taylor and Francis, London, pp 91–94
Elkind MM, Sutton H, Moses WB (1967) Sublethal and lethal radiation damage. Nature 214:1088–1092
Emami B, Mittal BM, Sapareto S (1984) Sequencing of the total course of hyperthermia and radiation. Cancer Res 44(Suppl.):4731s-4732s
Engelhardt R (1987) Hyperthermia and drugs. Recent Results Cancer Res 104:136–203
Evanochko WT, Ng TC, Lilly MB, Lawson AJ, Corbett TH, Durant JR, Glickson JD (1983) In vivo 31P NMR study of the metabolism of murine mammary 16/C adenocarcinoma and its response to chemotherapy, X-radiation, and hyperthermia. Biochemistry 80:334–338
Fajardo LF (1984) Pathological effects of hyperthermia in normal tissues. Cancer Res [Suppl] 44:4826s-4835s
Field SB (1978) The response of normal tissue to hyperthermia alone or in combination with X-rays. In: Streffer C, van Beuningen D, Dietzel F, Röttinger E, Robinson E, Scherer E, Seeber S, Trott K-R (eds) Cancer therapy by hyperthermia and radiation. Proceedings of the second international symposium, Essen, June 2–4, 1977. Urban and Schwarzenberg, Baltimore, pp 37–48
Field SB, Hume SP (1988) Hyperthermia in animals. In: Fielden EM, Fowler JF, Hendry JH, Scott D (eds) Radiation research, vol 2. Taylor and Francis, London, pp 960–965
Field SB, Hume S, Law MP, Morris C, Meyers R (1976) Some effects of combined hyperthermia and ionizing radiation on normal tissues. In: Proceedings of the international symposium on radiobiology research needed for the improvement of radiotherapy. International Atomic Energy Commission, Vienna
Francesconi R, Mayer M (1979) Heat- and excercise-induced hyperthermia: effects on high-energy phosphate. Aviat. Space Environ Med 50:799–802
Frankel HM, Ferrante FL (1966) Effects of pCO2 on appearance of increased lactate during hyperthermia. Am J Physiol 210:1269–1272
Frascella D, Frankel HM (1969) Liver pyridine nucleotides, lactate, and pyruvate in hyperthermic rats. Am J Physiol 217:207–209
Freeman ML, Dewey WC, Hopwood LE (1977) Effect of pH on hyperthermic cell survival. J N C I 58:1837–1839
George KC, Hirst DG, McNally NJ (1977) Effect of hyperthermia on cytotoxicity of the radiosensitizer Ro-07–0582 in a solid mouse tumor. Br J Cancer 35:372–375
George KC, Singh BB (1982) Synergism of chloropromazine and hyperthermia in two mouse solid tumours. Br J Cancer 45:309–313
George KC, Singh BB (1985) Hyperthermic response of a mouse fibrosarcoma as modified by phenothiazine drug. Br J Cancer 51:737–738
George KC, van Beuningen D, Streffer C (1988) Growth cell proliferation and morphological alterations of mouse mammary carcinoma after exposure to X-rays and hyperthermia. In: Issels RD, Wilmanns W (eds) Application of hyperthermia in the treatment of cancer. Springer, Berlin Heidelberg New York, pp 113–117 (Recent results cancer res, vol 107)
George KC, Streffer C, Pelzer T (1989) Combined effects of X-rays, Ro-03–8799 and hyperthermia on growth, necrosis and cell proliferation in a mouse tumour. Int J Radiat Oncol Biol Phys 16:1119–1122
Gerner EW (1983) Thermotolerance. In: Storm FK (ed) Hyperthermia and cancer therapy. Hall, Boston, pp 141–162
Gerner EW (1985 a) Definition of thermal dose. In: Overgaard J (ed) Hyperthermic oncology vol II. Taylor and Francis, London, pp 245–251
Gerner EW (1985 b) Biological isoeffect relationships and dose for temperature induced cytotoxicity. In: Overgaard J (ed) Hyperthermic oncology, vol II. Taylor and Francis, London, pp 253–262
Gerner EW, Leith JT (1977) Interaction of hyperthermia with radiation of different linear energy transfer. Int J Radiat Biol 31:238–288
Gerner EW, Schneider MJ (1975) Induced thermal resistance in HeLa cells. Nature 256:500–502
Gerner EW, Connor WG, Boone MLM, Doss JD, Mayer EG, Miller RG (1975) The potential of localized heating as an adjunct to radiation therapy. Radiology 116:433–489
Gerner EW, Leith JT, Boone MLM (1976) Mammalian cell survival response following irradiation with 4 MeV X-rays or accelerated helium ions combined with hyperthermia. Radiology 119:715–720
Gerner EW, Holmes PW, McCullough JA (1979) Influence of growth state on several thermal response of EMT-6/Az tumor cells in vitro. Cancer Res 39:981–986
Gerweck LE (1977) Modification of cell lethality at elevated temperatures: the pH effect. Radiat-Res 70:224–235
Gerweck LE (1978) Influence of microenvironmental condition on sensitivity to hyperthermia or radiation for cancer therapy. In: Caldwell W, Durand R (eds) Proceedings of the symposium on clinical prospects of hypoxic cell sensitizers and hyperthermia. University of Wisconsin, Madison
Gerweck LE (1982) Effect of microenvironmental factors on the response of cells to single and fractionated heat treatments. N C I Monogr 61:19–25
Gerweck LE (1985) Environmental and vascular effect. In: Overgaard J (ed) Hyperthermic oncology, vol II. Taylor and Francis, London, pp 253–262
Gerweck LE, Bascomb F (1982) Influence of hypoxia on the development of thermotolerance. Radiat Res 90:356–361
Gerweck LE, Delaney TF (1984) Persistence of thermotolerance in slowly proliferating plateau phase cells. Radiat Res 97:365–372
Gerweck LE, Richards B (1981) Influence of pH on the thermal sensitivity of cultured human glioblastoma cells. Cancer Res 41:845–849
Gerweck LE, Nygaard TG, Burlett M (1979) Response of cells to hyperthermia under acute and chronic hypoxic conditions. Cancer Res 39:966–972
Gerweck LE, Richards B, Michaels HB (1982) Influence of low pH on the development and decay of 42°C thermotolerance in CHO cells. Int J of Radiat Oncol Biol Phys 8:1935–1941
Gilette EL (1985) Experimental studies of tumor response to hyperthermia alone or combined with other modalities. In: Overgaard J (ed) Hyperthermic oncology 1984. Taylor and Francis, London, pp 9–40
Giovanella BC (1983) Thermosensitivity of neoplastic cells in vitro. In: Storm FK (ed) Hyperthermia and cancer therapy. Hall, Boston, pp 55–62
Giovanella BC, Morgan AC, Stehlin JA, Williams LJ (1973) Selective lethal effect of supranormal temperatures on mouse sarcoma cells. Cancer Res 33:2568–2578
Giovanella BC, Stehlin JS, Morgan AC (1976) Selective lethal effects of supranormal temperatures on human neoplastic cells. Cancer Res 36:3944–3950
Goetze O, Schmidt KH (1931) Örtliche homogene Überwärmung gesunder und kranker Gliedmaßen. Deutsche Z Chir 234:623–670
Goldin EM, Leeper DB (1981) The effect of low pH on thermotolerance induction using fractionated 45°C hyperthermia. Radiat Res 85:472–479
Goss P, Parsons PG (1977) The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cells lines. Cancer Res 37:152–156
Guffy MM, Rosenberger JA, Simon J, Burns CP (1982) Effect of cellular fatty acid alteration on hyperthermic sensitivity in cultured L1210 murine leukemia cells. Cancer Res 42:3625–3630
Guy AW, Chou Ch-K (1983) Physical aspects of localized heating by radiowaves and microwaves. In: Storm FK (ed) Hyperthermia in cancer therapy. Hall, Boston, pp 279–304
Haas GP, Klugo R, Hetzel FW, Barton EE, Cerny IC (1984) The synergistic effect of hyperthermia and chemotherapy on murine transitional cell carcinoma. J Urol 132:828–833
Hahn GM (1974) Metabolic aspects of the role of hyperthermia in mammlian cell inactivation and their possible relevance to cancer treatment. Cancer Res 34:3117–3123
Hahn GM (1978) Interactions of drugs and hyperthermia in vitro and in vivo. In: Streffer C, van Beuningen D, Dietzel F, Röttinger E, Robinson JE, Scherer E, Seeber S, Trott KR (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Baltimore, pp 72–79
Hahn GM (1979) Potential for therapy of drugs and hyperthermia. Cancer Res 39:2264–2268
Hahn GM (1980) Comparison of the malignant potential of 10T1/2 cells and transformants with their survival responses to hyperthermia and to amphotericin B. Cancer Res 40:3763–3767
Hahn GM (1982) Hyperthermia and cancer. Plenum, New York
Hahn GM, Shiu EC (1983) Effect of pH and elevated temperature on the cytotoxicity of some chemotherapeutic agents on Chinese hamster cells in vitro. Cancer Res 43:5789–5791
Hahn GM, Shiu EC (1986) Adaptation to low pH modifies thermal and thermo-chemical response of mammalian cells. Int J Hyperthermia 2:379–387
Hahn GM, Strande DP (1976) Cytotoxic effects of hyperthermia and adriamycin on Chinese hamster cells. J N C I 57:1063–1067
Hahn GM, Braun J, Har-Kedar I (1975) Thermochemotherapy: synergism between hyperthermia (42°-43 °C) and adriamycin (or bleomycin) in mammalian cell inactivation (cancer chemotherapy/cell membranes). Proc Natl Acad Sci USA 72:937–940
Hall E (1978) Radiobiology for the radiologist. Harper and Row, Hagestown
Hand JW (1987) Heat delivery and thermometry in clinical hyperthermia. In: Streffer C (ed) Hyperthermia and the therapy of malignant tumors. Springer, Berlin Heidelberg New York, pp 1–23 (Recent results cancer research, vol 104)
Hand JW, Walker H, Hornsey S, Field SB (1979) Effect of hyperthermia on the mouse testis and its response to X-rays, as assayed by weight loss. Int J Radiat Biol 35:521–528
Harisiadis L, Hall EJ, Kraljevic U, Borek C (1975) Hyperthermia: biological studies at the cellular level. Radiology 117:447–452
Harris M (1967) Temperature-resistant variants in clonal populations of pig kidney cells. Exp Cell Res 46:301–314
Harris M (1969) Growth and survival of mammalian cells under continuous thermal stress. Exp Cell Res 56:382–386
Harris AB, Erickson L, Kending JH, Mingrino S, Goldring S (1962) Observations on selective brain heating in dogs. J Neurosurg 19:514–521
Hassanzadeh M, Chapman IV (1983) Thermal enhancement of bleomycin-induced tumor growth delay: the effect of dose fractionation. Eur J Cancer Clin Oncol 19:1517–1519
Havemann J (1983 a) Influence of a prior heat treatment on the enhancement by hyperthermia of X-ray-induced inactivation of cultured mammalian cells. Int J Radiat Biol 43:267–280
Havemann J (1983 b) Influence of pH and thermotolerance on the enhancement of X-ray induced inactivation of cultured mammalian cells by hyperthermia. Int J Radiat Biol 43:281–289
Havemann J, Hahn GM (1981) The role of energy in hyperther-mia-induced mammalian cell inactivation: a study of the effects of glucose starvation and an uncoupler of oxidative phosphorylation. J Cell Physiol 107:237–241
Hayat H, Friedberg I (1986) Heat-induced alterations in cell membrane permeability and cell inactivation of transformed mouse fibroblasts. Int J Hyperthermia 2:369–378
Hazan G, Ben-Hur E, Yerushalmi A (1981) Synergism between hyperthermia and cyclophosphamide in vivo: the effect of dose fractionation. Eur J Cancer 17:681–684
Hazan G, Lurie H, Yerushalmi A (1984) Sensitization of combined cis-platinum and cyclophosphamide by local hyperthermia in mice bearing the Lewis lung carcinoma. Oncology 41:68–69
Heddle JA (1973) A rapid in vivo test for chromosomal damage. Mutat Res 18:187–190
Hengstebeck S (1983) Untersuchungen zum Intermedialerstoff-wechsel in der Leber und in einem Adenocarcinom der Maus nach Hyperthermie. Dissertation, Universität-Gesamthochschule Essen
Henle KJ (1982) Thermotolerance in the murine jejenum. J N C I 68:1033–1036
Henle KJ (1983) Arrhenius analysis of thermal responses. In: Storm FK (ed) Hyperthermia and cancer therapy. Hall, Boston, pp 47–53
Henle KJ, Dethlefsen LA (1980) Time-temperature relationships for heat-induced cell killing of mammalian cells. Ann N Y Acad Sci 335:234–253
Henle KJ, Leeper DB (1976) Interaction of hyperthermia and radiation in CHO cells: recovery kinetics. Radiat Res 66:505–518
Henle KJ, Leeper DB (1979) Effects of hyperthermia (45 °C) on macromolecular synthesis in Chinese hamster ovary cells. Cancer Res 39:2665–2674
Henle KJ, Bitner AF, Dethlefsen LA (1979) Induction of ther-motolerance by multiple heat fractions in Chinese hamster ovary cells. Cancer Res 39:2486–2491
Henle KJ, Peck JW, Higashikubo R (1983) Protection against heat-induced cell killing in polyols in vitro Cancer Res 43:1624–1627
Henle KJ, Nagle WA, Moss AJ, Herman TS (1984) Cellular ATP content of heated Chinese hamster ovary cells. Radiat Res 97:630–633
Henriques FC Jr (1947) Studies on thermal injury. Arch Pathol 43:489–502
Herman TS, Cress AE, Sweets C, Gerner EW (1981) Reversal of resistance to methotrexate by hyperthermia in Chinese hamster ovary cells. Cancer Res 41:3840–3843
Herman TS, Sweets CC, White DM, Gerner EW (1982) Effect of rate of heating on lethality due to hyperthermia and selected chemotherapeutic drugs. J N C I 68:487–492
Hill SA, Denekamp J (1979) The response of six mouse tumours to heat and X-rays: Implications for therapy. Brit J Radiol 52:209–218
Hinkelbein W, Menger D, Birmelin M, Engelhardt R (1984) The influence of whole-body hyperthermia on myelotoxicity of doxorubicin and irradiation in rats. In: Proceedings of the 4th international symposium on hyperthermic oncology, vol 1. Aarhus, 2–6 July 1984, pp 281–283
Hiramoto R, Ghanta VK, Lilly MB (1984) Reduction of tumor burden in a murine osteosarcoma following hyperthermia combined with cyclophosphamide. Cancer Res 44: 1405–1408
Holohan EV, Highfield DP, Dewey WC (1982) Induction during G of heat radiosensitization in Chinese hamster ovary cells following single and fractionated heat doses. NCI Monogr 61:123–125
Holohan EV, Highfield DP, Holohan PK, Dewey WC (1984) Hyperthermic killing and hyperthermic radiosensitization in Chinese hamster ovary cells: effects of pH and thermal tolerance. Radiat Res 97:108–131
Honess DJ, Bleehen NM (1982) Sensitivity of normal mouse marrow and RIF-1 tumor to hyperthermia combined with cyclophosphamide or BCNU: a lack of therapeutic gain. Br J Cancer 46:236–248
Hones DJ, Bleehen NM (1985) Potentiation of melphalan by systemic hyperthermia in mice: therapeutic gain for mouse lung microtumours. Int J Hyperthermia 1:57–68
Honesss DJ, Donaldson J, Workman P, Bleehen NM (1985) The effect of systematic hyperthermia on melphalan pharmacokinetics in mice. Br J Cancer 51:77–84
Hume SP (1985) Experimental studies of normal tissue response to hyperthermia given alone or combined with radiation. In: Overgaard J (ed) Hyperthermic oncology, vol II. Taylor and Francis, London, pp 53–70
Hume SP, Marigold JCL (1980) Transient, heat induced, thermal resistance in the small intestine of mouse. Radiat Res 82:526–535
Hume SP, Myers R (1984) An unexpected effect of hyperthermia in the expression of X-ray damage in mouse skin. Radiat Res 97:186–199
Hume SP, Rogers MA, Field SB (1978) Two qualitatively different effects of hyperthermia on acid phosphatase staining in mouse spleen, dependent on the severity of the treatment. Int J Radiat Biol 34:401–409
Hume SP, Marigold JCL, Field SB (1979) The effects of local hyperthermia on the small intestine of mouse. Br J Radiol 52:657–662
Hume SP, Marigold JC, Michalowski A (1983) The effect of local hyperthermia on nonproliferative, compared with proliferative, epithelial cells of the mouse intestinal mucosa. Radiat Res 94:252–262
Hume SP, Marigold JCA, Manjil LG (1988) Thermotolerance in preirradiated intestine and its influence on time-temperature relationships. Radiat Res 113:375–387
Isbruch Ch (1986) Untersuchungen zum Glukosestoffwechsel menschlicher Melanomzellen in vitro nach Hyperthermie, Bestrahlung und Glukosegabe. Dissertation, Universität-Gesamthochschule Essen
Issa M (1985) Hyperthermie am Dünndarm der Maus. Eine elektronenmikroskopische Untersuchung. Dissertation, Essen.
Jackson DJ, Dickson JA (1979) Combination of hyperthermia (42 °C) and hyperglycemia in the treatment of the MC7 sarcoma. Br J Cancer 40:306
Jähde E, Rajewsky MF (1982) Sensitization of clonogenic malignant cells to hyperthermia by glucose-mediated, tumour-selective pH reduction. J Cancer Res Clin Oncol 104:23–30
Jain RK (1983) Bioheat transfer: mathematical models of thermal systems. In: Storm FK (ed) Hyperthermia in cancer therapy. Hall, Boston pp 9–46
Johnson HA, Pavelec M (1973) Thermal enhancement of thio-TEPA cytotoxicity. J N C I 50:903–908
Johnson FH, Eyring H, Polisar MJ (1954) The kinetic basis of molecular biology. Wiley, New York
Jorritsma JBM, Konings AWT (1983) Inhibition of radiation-induced strand breaks by hyperthermia and its relationship to cell survival after hyperthermia alone. Int J Radiat Biol 43:505–516
Jorritsma JBM, Konings AWT (1984) The occurrence of DNA strand breaks after hyperthermic treatments of mammalian cells with and without radiation. Radiat Res 98:198–208
Jorritsma JBM, Konings AWT (1986) DNA lesions in hyperthermic cell killing: effects of thermotolerance, procaine and erythritol. Radiat Res 106:89–97
Jorritsma JBM, Kampinga HH, Konings AWT (1984) Role of DNA polymerase in the mechanisms of damage by heat and heat plus radiation in mammalian cells. In: Overgaard J (ed) Hyperthermic oncology, vol II. Taylor and Francis, London, pp 61–64
Jorritsma JBM, Kampinga HH, Saf AHJ, Konings AWT (1985) Strand break repair, DNA polymerase and heat radiosensitization in thermotolerant cells. Int J Hyperthermia 1:131–145
Jorritsma JBM, Burgman P, Kampinga HH, Konings AWT (1986) DNA polymerase activity in heat killing and hyperthermic radiosensitization of mammalian cells as observed after fractionated heat treatments. Radiat Res 105:307–319
Joshi DS, Barendsen GW (1984) Hyperthermic modification of drug effectiveness for reproductive death of cultured mammalian cells. Indian J Exp Biol 22:251–254
Joshi DS, Jung H (1979) Thermotolerance and sensitization induced in CHO cells by fractionated hyperthermic treatments at 38°-45°C. Eur J Cancer 15:345–350
Jung H (1982) Interaction of thermotolerance and thermosen-sitization induced in CHO cells by combined hyperthermic treatments at 40° and 43°C. Radiat Res 91:433–446
Jung H (1986) A generalized concept for cell killing by heat. Radiat Res 106:56–72
Jung H, Dikomey E (1988) Some basic effects in cellular ther-mobiology. Rec Results Cancer Res 107:104–112
Jung H, Kölling H (1980) Induction of thermotolerance and sensitization in CHO cells by combined hyperthermic treatments at 40° and 43°C. Eur J Cancer 16:1523–1528
Jung H, Dikomey E, Zywitz F (1986) Ausmaß und zeitliche Entwicklung der Thermotoleranz und deren Einfluß auf die Strahlenempfindlichkeit von soliden Transplantationstumoren. In: Streffer C, Herbst M, Schwabe H (eds) Lokale Hyperthermie. Deutscher Ärzte Verlag, Köln, pp 23–38
Kachani ZFC, Sabin AB (1969) Reproductive capacity and viability at higher temperatures of various transformed hamster cell lines. J N C I 43:469–480
Kal HB, Hahn GM (1976) Kinetic responses of murine sarcoma cells to radiation and hyperthermia in vivo and in vitro. Cancer Res 36:1923–1929
Kal HB, Hatfield M, Hahn GM (1975) Cell cycle progression of murine sarcoma cells after X-irradiation or heat shock. Radiology 117:215–217
Kampinga HH, Jorritsma JBM, Konings AWT (1985) Heat-induced alterations in DNA polymerase activity of HeLa cells and of isolated nuclei. Relation to cell survival. Int J Radiat Biol 47:29–40
Kampinga HH, Luppes JG, Konings AWT (1987) Heat-induced nuclear protein binding and its relation to thermal cytotoxicity. Int J Hyperthermia 3:459–465
Kano E, Furukawa M, Yoshikawa S, Tsubouchi S, Kondo T, Sugahara T (1984) Hyperthermic chemopotentiation and chemical thermosensitisation. In: Hyperthermic oncology 1984, vol 1, summary papers. Proceedings of the 4th international symposium on hyperthermic oncology, Aarhus, 2–6 July 1984, pp 437–440
Kapp DA, Hahn GM (1979) Thermosensitization by sulfhydryl compounds of exponentially growing Chinese hamster cells. Cancer Res 39:4630–4635
Kase K, Hahn GM (1975) Differential heat response of normal and transformed human cells in tissue culture. Nature 255:228–230
Kellerer AM, Rossi HH (1971) RBE and the primary mechanism of radiation action. Radiat Res 47:15–34
Kiefer J, Kraft-Weyrather W, Hlawica M (1976) Cellular radiation effects and hyperthermia influence of exposure temperature on survival of diploid yeast irradiated under oxygenated and hypoxic conditions. Int J Radiat Biol 30:293–300
Kim SH, Kim JH, Hahn EW (1975 a) The radiosensitization of hypoxic tumor cells by hyperthermia. Radiology 114:727–728
Kim SH, Kim JH, Hahn EW (1975 b) Enhanced killing of hypoxic tumor cells by hyperthermia. Br J Radiol 48:872–874
Kim SH, Kim JH, Hahn EW (1976) The enhanced killing of irradiated HeLa cells in synchronous culture by hyperthermia. Radiat Res 66:337–345
Kim SH, Kim JH, Hahn EW (1978) Selective potentiation of hyperthermia killing of hypoxic cells by 5-thin-D-glucose. Cancer Res 38:2935–2938
Kim SH, Kim JH, Hahn EW, Ensign NA (1980) Selective killing of glucose and oxygen-deprived HeLa cells by hyperthermia. Cancer Res 40:3459–3462
Kim JH, Kim SH, Alfieri A, Young CW (1984) Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells. Cancer Res 44:102–106
Klein ME, Frayer K, Bachur NR (1977) Hyperthermic enhancement of chemotherapeutic agents in L1210 leukemia. Bood 505:223
Konings AWT (1987) Effects of heat and radiation on mammalian cells. Radiat Physiol Chem 30:339–349
Konings AWT, Penninga P (1983) Role of reduced glutathione in cellular heat sensitivity and thermotolerance. Strahlentherapie 159:377–378
Konings AWT, Penninga P (1984) Role of reduced glutathione protein thiols, and pentose phosphate pathway in heat sensitivity and thermotolerance. In: Overgaard J (ed) Proceedings of the 4th international symposium on hyperthermia oncology, 2–6 July, Aarhus. Taylor and Francis, London, pp 115–118
Konings AWT, Penninga P (1985) On the importance of the level of glutathione and the activity of the pentose phosphate pathway in heat sensitivity and thermotolerance. Int J Radiat Biol 48:409–422
Konings AWT, Ruifrok ACC (1985) Role of membrane lipids and membrane fluidity and thermotolerance of mammalian cells. Radiat Res 102:86–98
Kubota Y, Nishimura R, Takai S, Umeda M (1979) Effect of hyperthermia on DNA single-strand breaks induced by bleomycin in HeLa cells. Jpn J Cancer Res 70:681–685
Kura Sh, Antoku Sh (1985) Time-lapse photographic studies of heated HeLa cells. In: Abe M, Takahashi M, Sugahara T (eds) Hyperthermia in cancer therapy. Nippon Hoshasen Kiki Kogyokai, Tokyo, pp 192–193
Lambert RA (1912) Demonstration of the greater susceptibility to heat of sarcoma cells. JAMA 59:2147–2148
Landry J, Chretien P (1983) Relationship between hyperthermia induced heat shock proteins and thermotolerance in Morris hepatoma cells. Can J Biochem Cell Biol 61:428–437
Landry J, Marceau N (1978) Rate-limiting events in hyperthermic cells killing. Radiat Res 75:573–578
Lange I, Zänker KS, Siewert JR, Bliimel G, Eisler K, Kolb E (1984) The effect of whole body hyperthermia on 5-fluorouracil pharmakokinetics in vivo and clonogenicity of mammalian colon cancer cells. Anticancer Res 4:27–32
Langendorff H, Langendorff M (1943) Über die Wirkung einer mit Ultrakurzwelle kombinierte Röntgenbehandlung auf das Ehrlich-Karzinom der Maus. Strahlentherapie 72:211–219
Langer M, Weidenmaier W, Röttinger EM (1982) Increased cytotoxicity of misonidazole by pH reduction and 41 °C hyperthermia in Chinese hamster cells. Strahlentherapie 158:688–691
Laszlo A (1988) Evidence for two states of thermotolerance in mammalian cells. Int J Hyperthermia 4:513–526
Law MP, Ahier RG (1982) Long-term thermal sensitivity of previously irradiated skin. Br J Radiol 55:913–915
Law MP, Ahier RG, Field SB (1978) The response of the mouse ear to heat applied alone or combined with X-rays. Br J Radiol 51:132–138
Law MP, Ahier RG, Field SB (1979) The effect of prior heat treatment on the thermal enhancement of radiation damage in the mouse ear. Br J Radiol 52:315–321
Law MP, Ahier RG, Somaia S (1987) Thermotolerance induced by fractionated hyperthermia: dependence on the interval between fractions. Int J Hyperthermia 3:433–439
Lee SY, Ryn KH, Kang MS, Song CW (1986) Effect of hyperthermia on the lactic acid and beta-hydroxybutyric acid content in tumours. Int J Hyperthermia 2:213–222
Leeper DB (1985) Molecular and cellular mechanisms of hyperthermia alone or combined with other modalities. In: Overgaard J (ed) Hyperthermic oncology 1984. Taylor and Francis, London, pp 9–40
Leith JT, Miller RC, Gerner EW, Brone MLM (1977) Hyperthermic potentiation. Biological aspects and applications to radiation therapy. Cancer 39:766–779
Lepock JR (1982) Involvement of membranes in cellular responses to hyperthermia. Radiat Res 92:433–438
Lepock JR, Massicotte-Nolan P, Ruled GS, Kruuv J (1981) Lack of correlation between hyperthermic cell killing, thermotolerance, and membrane lipid fluidity. Radiation Res 87:300–313
Lepock JR, Cheng KH, Al-Qysi H, Kruüv J (1983) Ther-motropic lipid and protein transitions in Chinese hamster lung cell membranes: relationship to hyperthermic cell killing. Can J Biochem Cell Biol 61:421–427
Levin W, Blair RM (1978) Clinical experience with combined whole-body hyperthermia and radiation. In: Streffer C, van Beuningen D, Dietzel F, Röttinger F et al. (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Baltimore, pp 322–325
Li GC (1984) Thermal biology and physiology in clinical hyperthermia: current status and future needs. Cancer Res [Suppl] 44:4886s-4893s
Li GC, Hahn GM (1978) Ethanol-induced tolerance to heat and to adriamycin. Nature 274:699–701
Li GC, Hahn GM (1980 a) A proposed operational model of thermotolerance based on effects of nutrients and the initial treatment temperature. Cancer Res 40:4501–4508
Li GC, Hahn GM (1980b) Adaptation to different growth temperatures modifies some mammalian cell survival responses. Exp Cell Res 128:475–485
Li DJ, Hahn GM (1984) Responses of RIF tumors to heat and drugs: dependence on tumor size. Cancer Treat Rep 68:1149–1151
Li GC, Shiu EC, Hahn GM (1980) Similarities in cellular inactivation by hyperthermia or by ethanol. Radiat Res 82:257–268
Li GC, Petersen NS, MitchellHK (1982 a) Induced thermal tolerance and heat shock protein synthesis in Chinese hamster ovary cells. Int J Radiat Oncol Biol Phys 8:63–67
Li GC, Fisher GA, Hahn GM (1982b) Induction of thermotolerance and evidence for a well-defined thermotropic cooperative process. Radiat Res 89:361–368
Li GC, Shrieve DC, Werb A (1982 c) Correlations between synthesis of heat-shock proteins and development of tolerance to heat and to Adriamycin and Chinese hamster fibroblasts: heat shock and other inducers. In: Schlesinger MJ, Ashburner J, Tissieres K (eds) Heat shock from bacteria to man. Cold Spring Habor, New York
Li DJ, Zhou SL, Qui SL, Qiao SJ (1987) Thermodamage, ther-mosensitivity and thermotolerance of normal swine oesophagus. Int J Hyperthermia 3:143–151
Li DJ, Qui SL, Zhou SL, Liu HL (1988) Acute heat injury to the normal swine rectum. Int J Hyperthermia 4:191–201
Lilly MB, Katholo ChR, Ng TC (1985) Direct relationship between high-energy phosphate content and blood flow in thermally treated murine tumors. J N C I 75:885–889
Lin PS, Turi A, Kwock L, Lu RC (1982) Hyperthermia effect on microtubule organization. NCI Monogr 61:57–60
Lin PS, Cariani PA, Jones M, Kahn PC (1983) Work in progress: the effect of heat on bleomycin cytotoxicity in vitro and on the accumulation of co-bleomycin in heat-treated rat tumors. Radiology 146:213–217
Lokshina AM, Song CW, Rhee JG, Levitt SH (1985) Effect of fractionated heating on the blood flow in normal tissues. Int J Hyperthermia 1:117–129
Longo FW, Tomashefsky P, Rivin BD, Tannenbaum M (1983) Intraction of ultrasonic hyperthermia with two alkylating agents in a murine bladder tumor. Cancer Res 43: 3231–3235
Lorenz M, Biwer E, Habs M, Schmähl D (1984) Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch N-nitrose-l,3-bis-(2-chloroethyl)-harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom. 2. Mitteilung: Monochemot-herapie in Kombination mit nachfolgender Hyperthermie in unterschiedlichen Zeitintervallen. Langenbecks Arch. Chir 362:253–261
Loshek DD, Orr JS, Solomonidis E (1977 a) Interaction of hyperthermia and radiation: the survival surface. Br J Radiol 50:893–901
Loshek DD, Orr JS, Solomonidis E (1977 b) Interaction of hyperthermia and radiation: temperature coefficient of interaction. Br J Radiol 50:902–907
Loshek DD, Orr JS, Solomonidis E (1981) Interaction of hyperthermia and radiation: radiation quality. Br J Radiol 54:40–47
Loven DP, Leeper DB, Oberley LW (1985) Superoxide dismutase levels in Chinese hamster ovary cells and ovarian carcinoma cells after hyperthermia or exposure to cycloheximide. Cancer Res 45:3029–3033
Lücke-Huhle C, Dertinger H (1977) Kinetic response of an in vitro tumor model (V99 spheroids) to 42°C hyperthermia. Eur J Cancer 13:23–28
Lunec J, Cresswell SR (1983) Heat-induced thermotolerance expressed in the energy metabolism of mammalian cells. Radiat Res 93:588–597
Lunec J, Hesslewood JP, Parker R, Leaper S (1981) Hyperthermic enhancement of radiation cell killing in HeLa S3 cells and its effect on the production and repair of DNA strand breaks. Radiat Res 85:116–125
Lyons BE, Obana WG, Borcich JK, Kleinman R, Singh D, Britt RH (1986) Chronic histological effects of ultrasonic hyperthermia on normal feline brain tissue. Radiat Res 106:234–251
Magin RL, Weinstein JN (1982) Delivery of drugs in temperature-sensitive liposomes. In: Gregoriadia C, Senior, Trouet L (eds) Targeting of drugs. Plenum, New York, pp 203–221
Magin RL, Siki BI, Cysyk RL (1979) Enhancement of bleomycin activity against Lewis lung tumors in mice by local hyperthermia. Cancer Res 39:3792–3795
Magin RL, Cysyk RL, Litterst CL (1980) Distribution of adriamycin in mice under conditions of local hyperthermia which improve systemic drug therapy. Cancer Treat Rep 64:203–210
Magun BE, Fennie ChW (1981) Effects of hyperthermia on binding, internalization, and degradation of epidermal growth factor. Radiat Res 86:133–146
Marmor JB (1979) Interaction of hyperthermia and chemotherapy in animals. Cancer Res 39:2269–2276
Marmor JB, Kozak D, Hahn GM (1979) Effects of systematically administered bleomycin or adriamycin with local hyperthermia on primary tumor and lung metastases. Cancer Treat Rep 63:1311–1325
Martinez A, Fajardo LF, Kernahan P, Prionas S, Hahn GM (1980) The effects of radio frequency heating on normal fat and muscular tissues: histologically based tissue injury grading system. In: Third international symposium: cancer therapy by hyperthermia, drugs and radiation, Fort Collins, June 22–26
Martinez AA, Meshorer A, Meyer JL, Hahn GM, Fajardo LF, Prionas SD (1983) Thermal sensitivity and thermotolerance in normal porcine tissues. Cancer Res 43:2072–2075
Massicotte-Nolan P, Glofcheski DJ, Kruuv J, Lepock JR (1981) Relationship between hyperthermic cell killing and protein denaturation by alcohols. Radiat Res 87:284–299
McCormick W, Penman SH (1969) Regulation of protein synthesis in HeLa cells: translation at elevated temperatures. J Mol Biol 39:315–333
Mehdi SQ, Recktenwald DJ, Smith LM, Li GC, Armour EP, Hahn GM (1984) Effect of hyperthermia on murine cell surface histocompatibility antigens. Cancer Res 44:3394–3397
Mella O (1985) Combined hyperthermia and cis-diam-minedichloroplatinum in BDIX rats with transplanted BT4A tumors. Int J Hyperthermia 1:171–183
Meyer KR, Hopwood LE, Gillette EL (1979) The thermal response of mouse adenocarcinoma cells at low pH. Eur J Cancer 15:1219–1222
Meyn RE, Corry PM, Fletcher SE, Demetriades M (1980) Thermal enhancement of DNA damage in mammalian cells treated with cis-diamminedichloroplatinum (II). Cancer Res 40:1136–1139
Mikkelsen RB, Wallach DFH (1982) Transmembrane ion gradients and thermochemotherapy. In: Gautherie MA (eds) Biomedical thermology. International symposium, Straßburg 1982. Liss, New York, pp 103–107
Milligan AJ, Metz JA, Leeper DB (1984) Effect of intestinal hyperthermia in the Chinese hamster. Int J Radiat Oncol Biol Phys 10:259–263
Mills MD, Meyn RE (1983) Hyperthermic potentiation on unre-joined DNA strand breaks following irradiation. Radiat Res 95:327–338
Mirtsch S, Streffer C, van Beuningen D, Rebmann A (1984) ATP metabolism in human melanoma cells after treatment with hyperthermia (42°C) In: Overgaard J (ed) Hyperthermic oncology 1984. Taylor and Francis, London, pp 19–22
Mirtsch S, Strohmenger U, Streffer C (1988) Glutathione level in melanoma cells and tissue. Recent Results Cancer Res 107:22–26
Mitchell JB, Russo A, Kinsella TJ, Glatstein E (1983) Glutathione elevation during thermotolerance induction and thermosensitization by glutathione depletion. Cancer Res 43:987–991
Mivechi NF, Dewey WC (1984) Effect of glycerol and low pH on heat-induced cell killing and loss of cellular DNA polymerase activities in Chinese hamster ovary cells. Radiat Res 99:352–362
Mizuno S, Ishida A (1981) Potentiation of bleomycin cytotoxicity toward cultured mouse cells by hyperthermia and ethanol. Jpn J Cancer Res 72:395–402
Mizuno S, Amagai M, Ishida A (1980) Synergistic cell killing by antitumor agents and hyperthermia in cultured cells. Jpn J Cancer Res 71:471–478
Mizuno S, Ishida A, Amagai M (1981) Potentiation of the action of antitumor agents by hyperthermia. Gano Kagakuryoho 8 [Suppl]:147–153
Mondovi B, Strom R, Rotilio G et al. (1969 a) The biochemical mechanism of selective heat sensitivity of cancer cells. I. Studies on cellular respiration. Eur J Cancer 5:129–136
Mondovi B, Finazzi-Agro A, Rotilio G, Strom R, Moricca G, Rossi-Fanelli A (1969) The biochemical mechanism of selective heat sensitivity of cancer cells. II. Studies on nucleic acids and protein synthesis. Eur J Cancer 5:137–146
Monson TP, Henle KJ, Moss AJ, Nagle WA (1984) Experimental test of the polyol hypothesis: the effect of aldose reductase inhibitors on thermotolerance development and measurements of intracellular sugar and polyol content in ther-motolerant CHO cells. In: Proceedings of the 32nd annual meeting of the Radiation Research Society (abstract). Orlando, Florida, p 62
Morgan JE, Bleehen NM (1981a) Response of EMT6 multicellular tumor spheroids to hyperthermia. Br J Cancer 43:384–391
Morgan JE, Bleehen NM (1981b) Interactions between misonidazole and hyperthermia in EMT6 spheroids. Br J Cancer 44:810–818
Morgan JE, Honess D, Bleehen NM (1979) The interaction of thermal tolerance with drug cytotoxicity in vitro. Br J Cancer 39:422–428
Morris CC, Field SB (1985) The relationship between heating time and temperature for rat tail necrosis with and without occlusion of the blood supply. Int J Radiat Biol 47:41–48
Morris CC, Myers R, Field SB (1977) The response of the rat tail to hyperthermia. Br J Radiol 50:576
Moritz A, Henriques FC (1947) Studies of thermal injury: II. The relative importance of time and surface temperature in the causation of cutaneous burns. Am J Pathol 23:695–720
Muckle DS, Dickson JA (1973) Hyperthermia (42°C) as an adjuvant to radiotherapy nad chemotherapy in the treatment of the allegeneic VX2 carcinoma in the rabbit. Br J Cancer 27:307–315
Murray D, Milas L, Meyn RE (1984) DNA damage produced by combined hyperglycemia and hyperthermia in two mouse fibrosarcoma tumors in vivo. Int J Radiat Oncol Biol Phys 10:1679–1682
Murthy MS, Khandekar JD, Travis JD, Scanion EF (1984) Combined effect of hyperthermia (HT) and platinum compounds in vivo and in vitro on murine and human tumor cells. In: Hyperthermic oncology 1984, vol 1. Proceedings of the 4th international symposium on hyperthermic oncology. Aarhus, 2–6 July 1984, pp 421–424
Nagle WA, Moss AJ Jr (1983) Inhibitors of poly (ADP-ribose) synthetase enhance the cytotoxicity of 42 °C and 45 °C hyperthermia in cultured Chinese hamster cells. Int J Radiat Biol 44:475–481
Nagle WA, Moss AJ, Baker ML (1982) Increased lethality at 42°C for hypoxic Chinese hamster cells heated under conditions of energy depreviation. NCI Monogr 61:107–110
Naruse Sh, Higuchi T, Horikawa Y, Tnaka Ch, Nakamura K, Hirakawa K (1986) Radiofrequency hyperthermia with successive monitoring of its effects on tumors using NMR spectroscopy. Proc Natl Acad Sci USA 83:8343–8347
Nauts HC (1985) Hyperthermic oncology: historic aspects and future trends. In: Overgaard J (ed) Hyperthermic oncology 1984. Taylor and Francis, London, pp 199–209
Neumann HA, Fiebig HH, Löhr GW, Engelhardt R (1985) Effects of cytostatic drugs and 40.5 °C hyperthermia on human clonogenic tumor cells. Eur J Cancer Clin Oncol 21:515–523
Nielsen OS (1984) Facitonated hyperthermia and thermotolerance. Danish Medical Bulletin 31:376–390
Nielsen OS, Overgaard J (1982 a) Influence of time and temperature on the kinetics of thermotolerance in LI A2 cells in vitro. Cancer Res 42:4190–4196
Nielsen OS, Overgaard J (1982 b) Importance of preheating temperature and time for the induction of thermotolerance in a solid tumour in vivo. Br J Cancer 46:894–903
Ngo FOH, Han A, Utsumi H, Elkind MM (1977) Comparative radiobiology of fast neutrons: relevance to radiotherapy and basic studies. Int J Radiat Oncol Biol Phys 3:187–193
Ohnoshi T, Ohnuma T, Beranek JT, Holland JF (1985) Combined cytotoxicity effect of hyperthermia and anthracycline antibiotics on human tumor cells. JNCI 71:275–281
Ohtsuka K, Nakamura W (1986) Modification of the thermal sensitivity of the murine foot and tumor by prior hypoxic treatment. Int J Hyperthermia 2:65–73
Ohyama H, Yamada T (1980) Reduction of rat thymocyte interphase death by hyperthermia. Radiat Res 82:342–351
Okumura Y, Reinhold H (1978) Heat sensitivity of rat skin. Eur J Cancer 14:1161–1166
Omar RA, Lanks KW (1984) Heat shock protein synthesis and cell survival in clones of normal and SV40-transformed mouse embryo cells. Cancer Res 44:3976–3982
Osieka R, Magin RL, Atkinson ER (1978) The effect of hyperthermia on human colon cancer xenografts in nude mice. In: Streffer C, van Beuningen D, Dietzel F, Röttinger E, Robinson JE, Scherer E, Seeber S, Trott K-R (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Baltimore, pp 287–290
Ossovski L, Sachs L (1967) Temperature sensitivity of polyoma virus: induction of cellular DNA synthesis and multiplication of transformed cells at high temperatures. Proc Natl Acad Sci USA 58:1938–1945
Ostrow S, van Echo D, Egorin M, Whitacre M, Grochow L, Aisner J, Colvin M, Bachur M, Bachur N, Wiernik PH (1982) Cyclophosphamide pharmacokinetics in patients receiving whole-body hyperthermia. NCI Monogr 61: 401–403
Overgaard J (1976 a) Ultrastructure of a murine mammary carcinoma exposed to hyperthermia in vivo. Cancer Res 36: 983–995
Overgaard J (1976 b) Combined adriamycin and hyperthermia treatment of a murine mammary carcinoma in vivo. Cancer Res 36:3077–3081
Overgaard J (1977) Effect of hyperthermia on malignant cells in vivo: a review and hypothesis. Cancer 39:2637–2646
Overgaard J (1980) Effect of misonidazole and hyperthermia on the radiosensitivity of a C3H mouse mammary carcinoma and its surrounding normal tissue. Brit J Cancer 41:10–21
Overgaard J (1981) Fractionated radiation and hyperthermia. Experimental and clinical studies. Cancer 48:1116–1123
Overgaard J (1985 a) History and heritage — an introduction. In: Overgaard J (ed) Hyperthermia oncology. Taylor and Francis, London, pp 3–8
Overgaard J (1985 b) Hyperthermic oncology. Taylor and Francis, London
Overgaard J, Suit H (1979) Time-temperature relationship in hyperthermic treatment of malignant and normal tissue in vivo. Cancer Res 39:3248–3253
Overgaard K (1934) Über Wärmetherapie bösartiger Tumoren. Acta Radiol. [Then] (Stockh.) 15:89–99
Overgaard K, Overgaard J (1972) Investigations on the possibility of a thermic tumor therapy: II. Action of combined heat-roentgen treatment on a transplanted mouse mammary carcinoma. Eur J Cancer 8:573–575
Overgaard K, Overgaard J (1974) Radiation sensitsitizing effect of heat. Acta Radiol. [Ther.] (Stockh.) 13:501–511
Palzer R, Heidelberger C (1973) Influence of drugs and synchrony on the hyperthermic killing of HeLa cells. Cancer Res 33:422–427
Panniers R, Henshaw EC (1984) Mechanism of inhibition of polypeptide chain initiation in heat-shocked Ehrlich ascites tumor cells. Eur J Biochem 140:209–214
Parks LC, Smith GV (1983) Systemic hyperthermia by extracorporal induction: techniques and results. In: Storm FK (ed) Hyperthermia in cancer therapy. Hall, Boston, pp 407–446
Pennes HH (1948) Analysis of tissue and arterial blood temperatures in the resting human forearm. J Applied Physiol 1:93–99
Pettigrew RT, Galt JM, Ludgate CM, Smith AN (1974) Clinical effects of whole-body hyperthermia in advanced malignancy. Br Med J 4:679–682
Pincus G, Fischer A (1931) The growth and death of tissue cultures exposed to supranormal temperatures. J Exp Med 54:323–332
Pomp H (1978) Clinical application of hyperthermia in gynecological malignant tumors. In: Streffer C, van Beuningen D, Dietzel F, Röttinger E, Robinson JE, Scherer E, Seeber S, Trott K-R (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Baltimore, pp 326–327
Power J, Harris J (1977) Response of extremely hypoxic cells to hyperthermia: survival and oxygen enhancement ratios for exponential and plateau-phase cultures. Radiology 123:767–770
Privalov PL (1979) Stability of proteins. Adv Protein Chem 33:167–241
Raaphorst GP, Spiro IJ, Azzam EJ, Sargent M (1987) Normal cells and malignant cells transfected with the HRas oncogene have the same heat sensitivity in culture. Int J Hyperthermia 3:209–216
Rabbani B, Sondhaus CA, Swingle KF (1978) Cellular response to hyperthermia and bleomycin: effect of time sequencing and possible mechanisms. In: Streffer C, van Beuningen D, Dietzel F, Röttinger E, Robinson JE, Scherer E, Seeber S, Trott K-R (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Baltimore, pp 291–293
Radford JR (1983) Effects of hyperthermia on the repair of X-ray-induced DNA double strand breaks in mouse L cells. Int J Radiat Biol 43:551–557
Rassow J (1987) Physikalisch-methodische Grundlagen der Strahlentherapie. In: Scherer E (ed) Strahlentherapie. Springer, Berlin Heidelberg New York, pp 1–105
Read RA, Fox MH, Bedford JS (1983) The cell cycle dependence of thermotolerance. Radiat Res 93:93–106
Reeves O (1972) Mechanism of acquired resistance to acute heat shock in cultured mammalian cells. J Cell Physiol 79:157–159
Reeves O (1982) Mechanism of acquired resistance to acute heat shock in cultured mammalian cells. J Cell Physiol 79:157–159
Reinhold HS, Wike-Hooley JL, van den Berg AP, van den Berg-Blok A (1984) Environmental factors, blood flow and microcirculation. In: Overgaard J (ed) Hyperthermic oncology, vol II. Francis and Taylor, London, pp 41–52
Reinhold HS, Wike-Hooley JL, van den Berg AP, van den Berg-Blok A (1985) Environmental factors, blood flow and microcirculation. In: Overgaard J (ed) Hyperthermic oncology 1984, vol. II. Taylor and Francis, London, pp 41–52
Reiter T, Penman S (1983) Prompt heat shock proteins: transla-tionally regulated synthesis of new proteins associated with the nuclear matrix-intermediate filaments as an early response to heat shock. Proc Natl Acad Sci USA 80:4737–4741
Rice LC, Urano M, Maher J (1982) The kinetics of thermotolerance in the mouse foot. Radiat Res 89:291–297
Robins HI, Dennis WH, Slattery IS, Lange TA, Yatvin MB (1983) Systemic lidocaine enhancement of hyperthermia-in-duced tumor regression in transplantable murine tumor models. Cancer Res 43:3187–3191
Robinson JE, Wizenberg MJ (1974) Thermal sensitivity and the effect of elevated temperatures on the radiation sensitivity of Chinese hamster cells. Acta Radiol [Ther] (Stockh) 13:241–249
Robinson JE, Wizenberg MJ, McCready W, Scheltema J (1974) Combined hyperthermia and radiation suggest an alternative to heavy particle therapy for reduced oxygen enhancement ratios. Nature 251:521–522
Rofstad EK, Brustad T (1986) Arrhenius analysis of the heat response in vivo and in vitro of human melanoma xenografts. Int J Hyperthermia 2:359–368
Rofstad EK, Wahl A, Tveit KM, Monge OR, Brustad T (1985) Survival curves after X-ray and heat treatments for melanoma cells derived directly from surgical specimens of tumors in man. Radiother Oncol 4:33–44
Rose WC, Veras GH, Laster WR Jr, Schabel FM Jr (1979) Evaluation of whole-body hyperthermia as an adjunct to chemotherapy in murine tumors. Cancer Treat Rep 63:1311–1325
Roti Roti JL (1982) Heat-induced cell death and radiosensitiza-tion: molecular mechanisms. NCI Monogr 61:3–9
Roti Roti JL, Henle KJ (1979) Comparison of two mathematical models for describing heat-induced cell killing. Radiat Res 78:522–531
Roti Roti JL, Painter RB (1982) Effects of hyperthermia on the Sedimentation of nucleoids from HeLa cells in sucrose gradients. Radiat Res 89:166–175
Rotstein LE, Daly J, Rozsa P (1983) Systemic ther-mochemotherapy in a rat model. Can J Surg 26:113–116
Rowley R, Joyner DE, Stewart JR (1987) In vitro response to hyperthermia or X-irradiation of diploid and tetraploid RIF-1 cells separated by centrifugal elutriation. Int J Hyperthermia 3:235–244
Ruifrok ACC, Kanon B, Hulstaart CE, Konings AWT (1984) Permeability change of cells treated with hyperthermia alone and in combination with X-irradiation. In: Overgaard J (ed) Hyperthermic oncology, vol I. Taylor and Francis, London, pp 65–68
Ruifrok ACC, Kanon B, Konings AWT (1985 a) Correlation between cellular survival and potassium loss in mouse fibroblasts after hyperthermia alone and after a combined treatment with X-rays. Radiat Res 101:326–331
Ruifrok ACC, Kanon B, Konings AWT (1985 b) Correlation of colony forming ability of mammalian cells with potassium content after hyperthermia under different experimental conditions. Radiat Res 103:452–454
Ruifrok ACC, Kanon B, Konings AWT (1986) Na+/K+ ATPase activity in mouse lung fibroblasts and HeLa S-3 cells during and after hyperthermia. Int J Hyperthermia 2:51–59
Ruifrok ACC, Kanon B, Konings AWT (1987) Heat-induced K+ loss, trypan blue uptake, and cell lysis in different cell lines: effect of serum. Radiat Res 109:303–309
Russo A, Mitchell JB, McPherson S (1984) The effects of glutathione depletion on thermotolerance and heat stress protein synthesis. Br J Cancer 49:753–758
Sapareto SA (1987) A workshop on thermal dose in cancer therapy: introduction. Int J Hyperthermia 3:289–290
Sapareto SA, Hopwood L, Dewey W, Raju M, Gray J (1978) Effects of hyperthermia on survival and progression of Chinese hamster overy cells. Cancer Res 38:393–400
Schamhart DHJ, van Walraven HS, Weigant FAC, Linnemans WAM, van Rijn J, van den Berg J, van Wijk R (1984) Thermotolerance in cultured hepatoma cells: cell viability, cell morphology, protein synthesis, and heat shock proteins. Radiat Res 98:89–95
Schlag H, Lücke-Huhle C (1976) Cytokinetic studies on the effect of hyperthermia on Chinese hamster lung cells. Eur J Cancer 12:827–831
Schlesinger MJ, Ashburner M, Tissieres A (eds) (1982) Heat shock: from bacteria to Man. Cold Spring Harbor Laboratory, Cold Spring Harbor
Schlesinger MJ, Aliperti G, Kelley PM (1982b) The response of cells to heat shock. Trends Biochem Sci 7:222–225
Schubert B, Streffer C, Tamulevicius P (1982) Glucose metabolism in mice during and after whole-body hyperthermia. N C I Monogr 61:203–205
Schulman N, Hall E (1974) Hyperthermia: its effect on proliferative and plateau phase cell cultures. Radiology 113: 207–209
Sciandra JJ, Subjeck JR (1984) Heat shock proteins and protection of proliferation and translation in mammalian cells. Cancer Res 44:5188–5194
Shah SA, Jain RK, Finney PL (1983) Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing W256 carcinosarcoma. Cancer Lett 19: 317–323
Shall S (1984) ADR-ribose in DNA repair: a new component of DNA excision repair. Adv Radiat Biol 11:1–69
Shenoy MA, Singh BB (1985) Temperature-dependent modification of radiosensitivity following hypoxic cytocidal action of delorpromazine. Radiat Environ Biophys 24:113–117
Sijens PE, Bovee WMMJ, Seijkens D, Koole P, Los G, van Rijs-sel RH (1987) Murine mammary tumor response to hyperthermia and radiotherapy evaluated by in vivo 31-P-nuclear magnetic resonance spectroscopy. Cancer Res 47: 6467–6473
Silberman AW, Rand RW, Storm FK, Drury FB, Benz ML, Morton DL (1985) Phase 1 trial of thermochemotherapy for brain malignancy. Cancer 56:48–56
Simard R, Bernhard W (1967) A heat-sensitive cellular function located in the nucleolus. J Cell Biol 34:61–76
Simpson TA, La Russa PG, Mullins DW, Daugherty JP (1987) Restoration of hyperthermia-associated increased protein to DNA ratio of nucleoids. Int J Hyperthermia 3:49–62
Singer SJ, Nicolson GI (1972) The fluid mosaic model of the structure of cell membranes. Science 175:720–731
Skibba JL, Collins FG (1978) Effect of temperature on biochemical functions in the isolated perfused rat liver. J Surg Res 24:435–441
Sminia P, Haveman J, Wondergem J, van Dijk JDP, Lebesque JV (1987) Effects of 434 MHz microwave hyperthermia applied to the rat in the region of the cervical spinal cord. Int J Hyperthermia 3:441–452
Song CW, Clement SS, Levitt SH (1977) Cytotoxic and radiosensitizing effects of 5-thio-D-glucose hypoxic cells. Radiology 123:201–205
Song CW, Kang MS, Rhee JG, Levitt S (1980) Vascular damage and delayed cell death in tumours after hyperthermia. Br J Cancer 41:309–312
Song CW, Rhee JG, Levitt SH (1982) Effect of hyperthermia on hypoxic cell fraction in tumors. Int J Radiat Oncol Biol Phys 8:851–856
Spiro IJ, Denman DL, Dewey WC (1982) Effect of hyperthermia on CHO DNA polymerase- and ß. Radiat Res 89:134–139
Stehlin JS Jr (1969) Hyperthermic perfusion with chemotherapy for cancers of the extremities. Surg Gynecol Obstet 120:305–308
Stehlin JS Jr, Giovanella BC, Ipolyi de PD, Muenz LR, Anderson RF (1975) Results of hyperthermic perfusion for melanoma of the extremities. Surg Gynecol Obstet 140:339–348
Stevenson MA, Minton KW, Hahn GM (1981) Survival and con-canavalin-A-induced capping in CHO fibroblasts after exposure to hyperthermia, ethanol, and X-irradiation. Radiation Res 86:467–478
Stewart FA, Denekamp J (1980) Fractionation studies with combined X-rays and hyperthermia in vivo. Brit J Radiol 53:346–356
Stone H (1978) Enhancement of local tumor control by misonidazole and hyperthermia. Br J Cancer 37 (Supp III): 178–183
Streffer C (1963) Reaktivität und Struktur von Aminosäuren und Proteinen (Cystein und β-Galaktosidase). Dissertation, Universität Freiburg
Streffer C (1969) Strahlen-Biochemie. Springer, Berlin Heidelberg New York
Streffer C (1982) Aspects of biochemical effects by hyperthermia. N C I Monogr 61:11–16
Streffer C (1985 a). Mechanism of heat injury. In: Overgaard J (ed) Hyperthermic oncology 1984. Taylor and Francis, London, pp 213–222
Streffer C (1985 b) Metabolic changes during and after hyperthermia. Int J Hyperthermia 1:305–319
Streffer C (1987) Biological basis for the use of hyperthermia in tumour therapy. Strahlentherapie 163:416–419
Streffer C (1988 a) Aspects of metabolic changes of hyperthermia. In: Issels RD, Wilmanns W (eds) Application of hyperthermia in the treatment of cancer. Springer, Berlin Heidelberg New York, pp 7–16 (Recent results in cancer res, vol 107)
Streffer C (1988 b) Effects of hyperthermic treatments on malig-nant cells and animal tumors: introductory remarks. In: Hinkelbein W et al. (eds) Preclinical hyperthermia. Springer, Berlin Heidelberg New York, pp 89–95 (Recent results in cancer res, vol 109)
Streffer C, van Beuningen D (1985) Zelluläre Strahlenbiologie und Strahlenpathologie (Ganz- und Teilkörperbestrahlung). In: Diethelm L, Heuck F, Olsson O, Strnad F, Vieten H, Zup-pinger A (eds) Handbuch der medizinischen Radiologie, vol XX. Springer, Berlin Heidelberg New York, pp 1–39
Streffer C, van Beuningen D, Elias S (1977) Comparative effects of tritiated water and thymidine on the preimplanted mouse embryos in vitro. Curr Top Radiat Res Q 12:182–193
Streffer C, van Beuningen D, Dietzel F, Röttinger E, Robinson JE, Scherer E, Seeber S, Trott K-R (1978) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Baltimore
Streffer C, van Beuningen D, Zamboglou N (1979) Cell killing by hyperthermia and radiation in cancer therapy. In: Abe M, Sakamoto K, Philips TL (eds) Treatment of radioresistant cancers. Elsevier/North-Holland Biomedical, Amsterdam, pp 55–70
Streffer C, Hengstebeck S, Tamulevicius P (1981) Glucose metabolism in mouse tumor and liver with and without hyperthermia. Henry Ford Hosp Med J 29:41–44
Streffer C, Tamulevicius P, Schmidt K (1983 a) Poly (ADPR) synthetase activity in melanoma cells after hyperthermia and radiation. Radiat Res 94:589 (abstract)
Streffer C, van Beuningen D, Bertholdt G, Zamboglou N (1983 b) Some aspects of radiosensitization by hyperthermia: neutrons and X-rays. In: Kano E (ed) Fundamentals of cancer therapy by hyperthermia, radiation and chemicals. MAG Tokyo, pp 121–134
Streffer C, van Beuningen D, Uma Devi P (1984) Radiosensitization by hyperthermia in human melanoma cells: single and fractionated treatments. Cancer Treat Rev 11:179–185
Strom R, Crifo C, Rossi-Fanelli A, Mondovi B (1977) Biochemical aspects of heat sensitivity of tumor cells. In: Rossi-Fanelli A, Cavalière R, Mondovi B, Morrica G (eds) Selective heat sensitivity of cancer cells. Springer, Berlin Heidelberg New York, pp 7–35
Subjek JR, Sciandra JJ, Johnson RJ (1982) Heat shock proteins: a comparison of induction kinetics. Br J Radiol 55:579–584
Suit HD, Shwayder M (1974) Hyperthermia: potential as an anti-tumor agent. Cancer 34:122–129
Suzuki K (1967) Application of heat to cancer chemotherapy: experimental studies. Nagoya J Med Sci 30:1–21
Tacker JR, Anderson RU (1982) Delivery of antitumor drugs to bladder cancer by use of phase transition liposomes and hyperthermia. J Urol 127:1211–1214
Takeda M, Majima H, Okada S, Suzuki N, Kubodera A (1987) Surviving fractions and cure-rate in spheroids by X-rays or heat. In: Onoyama Y (ed) Hyperthermic oncology ’86 in Japan. MAG Tokyo, pp 157–158
Takeshita M, Grollmann AP, Ohtsubo E et al. (1978) Interaction of bleomycin with DNA. Proc Natl Acad Sci USA 75:5983–5987
Takiyama W (1984) Experimental studies on combined chemotherapy with hyperthermia and ethanol for advanced esophageal cancer. II. Effects of combined treatments on tumor growth in tumor-bearing mice. Nippon Geka Gakki Zasshi 85:118 (abstract)
Tamulevicius P, Streffer C (1983) Does hyperthermia produce increased lysosomal enzyme activity? Int J Radiat Biol 43:321–327
Tamulevicius P, Schmidt K, Streffer C (1984a) The effects of X-irradiation, hyperthermia and combined modality treatment on poly (ADPR) synthetase activity in human melanoma cells. Radiat Res 100:65–77
Tamulevicius P, Würzinger U, Luscher G, Streffer C (1984b) Lipid metabolism in mouse liver and adenocarcinoma following hyperthermia. In: Overgaard J (ed) Hyperthermic oncology 1984. Taylor and Francis, London, pp 23–26
Terasima T, Tolmach LJ (1963 a) Variations in several responses of HeLa cells to X-irradiation during the division cycle. Biophys J 3:11–33
Terasima T, Tolmach LJ (1963 b) X-ray sensitivity and DNA synthesis in synchronously dividing populations of HeLa cells. Science 140:490–492
Thislethwaite AJ, Alexander GA, Nerlinger RE, Moylan DJ, Leeper DB (1987) Modification of human tumor pH by elevation of blood glucose. Int J Radiat Oncol Biol Phys 13:603–610
Tomosovic SP, Steck PA, Heitzman D (1983) Heat stress proteins and thermal resistance in rat mammary cells. Radiat Res 95:399–413
Tomosovic SP, Rosenblatt PL, Johnston DA, Tang K, Lee PSY (1984) Heterogeneity in induced heat resistance and its relation to synthesis of stress proteins in rat tumor cell clones. Cancer Res 44:5850–5856
Tsuboi A (1988) Effects of hyperthermia on mouse L cells irradiated with fractionated X-rays. Int J Hyperthermia 4:655–664
Twentyman PR, Morgan JE, Donaldson J (1978) Enhancement by hyperthermia of the effect of BCNU against the EMT6 mouse tumor. Cancer Treat Rep 62:439–443
Urano M, Kahn J (1983) The change in hypoxic and chronically hypoxic cell fraction in murine tumors treated with hyperthermia. Radiat Res 96:549–559
Urano M, Kahn BS (1986) Differential kinetics of thermal resistance (thermotolerance) between murine normal and tumour tissues. Int J Radiat Oncol Biol Phys 12:89–93
Urano M, Kim MS (1983) Effect of hyperglycemia in ther-mochemotherapy of a spontaneous murine fibrosarcoma. Cancer Res 43:3041–3044
Urano M, Kim MS, Kenton L, Li ML (1985) Effect of ther-mochemotherapy (combined cyclophosphamide and hyperthermia) given at various temperatures with or without glucose administration on a murine fibrosarcoma. Cancer Res 45:4162–4166
van Beuningen D (1983) Hyperthermia als cytotoxisches und strahlensensibilisierendes Agens: zelluläre Effekte — eine Übersicht. Strahlentherapie 159:60–66
van Beuningen D, Streffer C (1988) Importance of thermotolerance for radiothermotherapie as assessed using too human melanoma cell lines. In: Hinkelbein W et al. (eds) Preclinical hyperthermia. Springer, Berlin Heidelberg New York, pp 203–213 (Recent results in cancer res, vol 109)
van Beuningen D, Molls M, Schulz S, Streffer C (1978) Effects of irradiation and hyperthermia on the development of preimplanted mouse embryos in vitro. In: Streffer C et al. (eds) Cancer therapy by hyperthermic and radiation. Urban and Schwarzenberg, Baltimore, pp 151–153
van Beuningen D, Issa M, Breipohl W, Streffer C, Raumwolf M (1983) Light- and electron-microscopical investigations on the effect of hyperthermia on the small intestine. Strahlentherapie 159:367 (abstract)
van Beuningen D, Streffer C, Pelzer T (1985) Radiosensitization of exponential and plateau phase cells. Strahlentherapie 161:552
Van der Linden PWG, Sapareto SA, Corbett TH, Valeriote FA (1984) Adriamycin and heat treatments in vitro and in vivo. Hyperthermic Oncology 1984, Vol. 1, Summary papers. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Aarhus, Denmark, 2–6 July 1984, pp 449–452
van Rijn J, van den Berg J, Schamhart DHJ, van Wijk R (1984) Effect of thermotolerance on thermal radiosensitization in hepatoma cells. Radiat Res 97:318–328
Vaupel P, Kallinowski F (1987) Physiological effects of hyperthermia. In: Streffer C (ed) Hyperthermia and the therapy of malignant tumors. Springer, Berlin Heidelberg New York, pp 71–109 (Recent results in cancer research, vol 104)
Vaupel P, Müller-Klieser W, Otte J, Manz R, Kallinowski F (1983 a) Durchblutung, Sauerstoffversorgung des Gewebes und pH-Verteilung in malignen Tumoren nach Hyperthermie. Pathophysiologische Grundlagen und Einfluß verschiedener Hyperthermiedosen. Strahlentherapie 159: 73–81
Vaupel P, Benzing H, Egelhof E, Müller-Klieser W, Müller-Schauenburg (1983 b) The effect of various thermal doses on the regional tumor blood flow measured by heat clearance. Strahlentherapie 159:384 (abstract)
Verma SP, Wallach DFH (1976) Erythrocyte membranes undergo cooperative, pH-sensitive state transitions in the physiological temperature range: Evidence from Raman spectroscopy. Proc Natl Acad Sci USA 73:3558–3561
Vexler AM, Litinskaya LL (1986) Changes in intracellular pH induced by hyperthermia and hypoxia. Int J Hyperthermia 2:75–81
Vidair CA, Dewey WC (1986) Evaluation of a role of Na+, K+, Ca2+, and Mg2+ in hyperthermic cell killing. Radiat Res 105:187–200
Vig BK, Cornforth M, Farook SAF (1982) Hyperthermic potentiation of chromosome aberrations by anticancer antibiotics. Cytogenet Cell Genet 33:35–41
von Ardenne M (1971) The cancer multi-step therapy concept. Panminerva Med 13:509–519
von Ardenne M (1975) Prinzipien und Konzept 1974 der Krebs-Mehrschritt-Therapie. Radiobiol Radiother 16:99–119
von Ardenne M (1978) On a new physical principle for selective local hyperthermia of tumor tissue. In: Streffer C, van Beun-ingen D, Dietzel F, Röttinger E, Robinson JE, Scherer E, Seeber S, Trott K-R (eds) Cancer therapy by hyperthermia and radiation. Proceedings of the second international symposium Essen, June 2–4 1977 Urban and Schwarzenberg, Baltimore, pp 96–104
von Ardenne M (1982) Selective multiphase cancer therapy: Conceptional aspects and experimental basis. 185 Adv. Pharmacol Chemother. 10:339–380
von Ardenne M, Reitnauer P (1976) Verstärkung der mit Glukoseinfusion erzielbaren Tumorübersäuerung in vivo durch NAD. Arch. Geschwulstforsch 30:319–330
von Ardenne M, Chaplain R, Reitnauer P (1969) Selektive Krebszellenschädigung durch eine Attackenkombination mit Übersäuerung Hyperthermie, Vitamin A, Dimethylsulfoxid und weiteren die Freisetzung lysosomaler Enzyme fördernder Agenzien. Arch Geschwulstforsch 33:331–344
Wallach D (1977) Basic mechanisms in tumor thermotherapy. J Mol Med 2:381–403
Wallach DHF (1978) Action of hyperthermia and ionizing radiation on plasma membranes: In: Streffer C, van Beuningen D, Dietzel F, Röttinger E, Robinson JE, Scherer E, Seeber S, Trott K-R (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Baltimore, p 19–28
Wallenfels K, Streffer C (1964) Chemische Reaktivität von Proteinen. In: 14. Colloquium der Gesellschaft für physiologische Chemie in Mosbach/Baden. Springer, Berlin Göttingen Heidelberg, pp 6–40
Wallenfels K, Streffer C (1966) Das Dissoziationsverhalten von Cystein und verwandten SH-Verbindungen. Biochem Z 346:119–132
Warburg O, Wind F, Negelein E (1926) Über den Stoffwechsel von Tumoren im Körper. Klin Wochenschr 5:829–834
Ward KA, Jain RK (1988) Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia. Int J Hyperthermia 4:223–250
Warocquier R, Scherrer K (1969) RNA metabolism in mammalian cells at elevated temperature. Eur J Biochem 10:362–370
Warters RL, Roti Roti JL (1982) Hyperthermia and the cell nucleus. Radiat Res 92:458–462
Warters RL, Stone OL (1983 a) Effects of hyperthermia on DNA replication in HeLa cells. Radiat Res 93:71–84
Warters RL, Stone OL (1983 b) Histone protein and DNA synthesis by HeLa cells and thermal schock. Radiat Res 96:646
Warters RL, Brizgys LM, Sharma R, Roti Roti JL (1986) Heat shock (45 °C) results in an increase of nuclear matrix protein mass in HeLa cells. Int J Radiat Biol 50:253–268
Weber G (1983) Biochemical strategy of cancer cells and the design of chemotherapy: GHA Glowes memorial lecture. Cancer Res 43:3466–3492
Weinstein JN, Magin RL, Cysyk RL, Zaharko DS (1980) Treatment of solid L1210 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexate. Cancer Res 40:1388–1395
Westermark F (1898) Über die Behandlung des ulcerierenden Cervixcarcinoms mittels konstanter Wärme. Zentralbl Gynae-kol 22:1335
Westermark N (1927) The effect of heat on rat tumors. Skand Arch Physiol 52:257–322
Westra A, Dewey WC (1971) Heat shock during the cell cycle of Chinese hamster cells in vitro. Int J Radiat Biol 19:467–477
Wiegant F, Karelaars A, Blok F, Linnemanns W (1984) Effects of extra cellular Ca2+ concentrations upon hyperthermia induced cell death. In: Overgaard J (ed) Hyperthermic oncology, vol I. Taylor and Francis, London, pp 3–6
Wike-Hooley JL, Faithfull NS, van der Zee J, van den Berg AP (1983) Liver damage and extraction of indocyamine green under whole body hyperthermia. Eur J Appl Physiol 51:269–279
Williamson DH, Lund P, Krebs HA (1967) The redox state of free nicotinamide adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J 103:514–527
Wizenberg M, Robinson JE (1975) Proceedings of the international symposium on cancer therapy by hyperthermia and radiation. American College of Radiology, Baltimore
Wondergem J, Havemann J (1983) The response of previously irradiation mouse skin to heat alone or combined with irradiation: influence of thermotolerance. Int J Radiat Oncol 44:539–552
Wondergem J, Begg A, Havemann J (1986) Effects of hyperthermia and X-irradiation on mouse stromal tissue. Int J Radiat Biol 50:65–76
Wondergem J, Strebel FR, Siddik ZH, Newman RA, Bull JMC (1988) The effects of anaesthetics on cis-platinum-induced toxicity at normal temperatures and during whole-body hyperthermia: the influence of NaCl concentration of the vehicle. Int J Hyperthermia 4:643–654
Wong RSL, Dewey WC (1982) Molecular studies on the hyperthermic inhibition of DNA synthesis in Chinese hamster ovary cells. Radiat Res 92:370–395
Yamada K, Someya F, Shimada S, Ohara K, Kukita A (1984) Thermochemotherapy for malignant melanoma: combination therapy of ACNU and hyperthermia in mice. J Invest Dermatol 82:180–184
Yamane T, Koga S, Maeta M, Hamazoe R, Karino T, Oda M (1984) Effects of in vitro hyperthermia on concentration of adriamycin in Ehrlich ascites cells. Hyperthermic oncology 1984, vol. 1, summary papers. Proceedings of the 4th international symposium on hyperthermic oncology, Aarhus, 2–6 July 1984, pp 409–412
Yatvin MB (1977) The influence of membrane lipid composition and procaine on hyperthermic death of cells. Int J Radiat Biol 32:513–521
Yatvin MB, Clifton KH, Dennis WH (1979) Hyperthermia and local anesthetics: potentiation of survival of tumor-bearing mice. Science 205:195–196
Yatvin MB, Mühlensiepen H, Porschen W, Weinstein JN, Feinendegen LE (1981) Selective delivery of liposome-associ-ated cis-dichlorodiamineplatinum (II) by heat and its influence on tumor drug uptake and growth. Cancer Res 41:1602–1607
Yatvin MB, Cree TC, Elson CE, Gipp JJ, Tegmo I-M, Vorpahl JW (1982) Probing the relationship of membrane fluidity to heat killing of cells. Radiat Res 89:644–646
Yatvin MB, Abuirmeileh NM, Vorpahl JW, Elson CE (1983 a) Biological optimization of hyperthermia: modification of tumor membrane lipids. Eur J Cancer 19:657–663
Yatvin M-B, Vorpahl JW, Gould MN, Lyte M (1983 b) The effects of membrane modification and hyperthermia on the survival of P-388 and V-79 cells. Eur J Cancer 19:1247–1253
Yi PN (1983) Hyperthermia-induced intracellular ionic level changes in tumor cells. Radiat Res 93:534–544
Zupi G, Badaracco G, Cavaliere R, Natali PG, Greco C (1984) Influence of sequence on hyperthermia and drug combination. Hyperthermic Oncology 1984, Vol. 1, Summary papers. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Aarhus, Denmark, 2–6 July 1984, pp 429–432
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Streffer, C. (1990). Biological Basis of Thermotherapy (With Special Reference to Oncology). In: Gautherie, M. (eds) Biological Basis of Oncologic Thermotherapy. Clinical Thermology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74939-1_1
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