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Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch N-Nitroso-1,3-bis-(2-chloroethyl)-harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom

2. Mitteilung: Monochemotherapie in Kombination mit nachfolgender Hyperthermie in unterschiedlichen Zeitintervallen

Effect of moderate local hyperthermia combined with chemotherapy by

Administration of N-Nitroso-1,3-bis(2-chloroethyl)urea (BCNU) on Yoshida sarcoma implated in the descending colon of rats

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Summary

There are numerous reports on in vitro and in vivo investigations of hyperthermia for cytostasis of malignant tumors. Combination of chemotherapy and hyperthermia is to potentiate the therapeutic effect. The time interval between the two types of therapy was the main subject of the present investigation. Local hyperthermia (43°C, 60 min) following BCNU chemotherapy at intervals of 0, 3, 6, 9, 12, and 24 h, respectively, was studied in a colonic Yoshida sarcoma model in Sprague-Dawley rats. No significant increase in the curing rate resulted from hyperthermic treatment. The results suggest that the highly anticipated hyperthermic peritoneal lavages should be investigated in controlled animal experiments prior to clinical use.

Zusammenfassung

Hyperthermie zur Cytostase von Malignomen ist in zahlreichen In-vitro- und In-vivo-Untersuchungen beschrieben worden. Die Kombination von Chemotherapie mit Hyperthermie soll zur Potenzierung der therapeutischen Wirkung führen. Ein Forschungsgegenstand ist der zeitliche Abstand zwischen beiden Therapiemodalitäten. Anhand eines Yoshida-ColonModells bei Sprague-Dawley-Ratten wurde eine lokale Hyperthermie (43°C, 60 min) im Abstand von 0, 3, 6, 9, 12 und 24 h nach einer Chemotherapie mit BCNU durchgeführt. Die Ergebnisse zeigten keine signifikante Steigerung der Heilungsrate durch die Hyperthermie. Angesichts unserer Ergebnisse sollten z.B. die mit groben Hoffnungen propagierten hyperthermen Peritoneallavagen erst im Tierexperiment einer kontrollierten Untersuchung unterzogen werden.

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Authors and Affiliations

  1. Institut für Toxikologie und Chemotherapie, Deutsches Krebsforschungszentrum Heidelberg, Im Neuenheimer Feld 280, D-6900, Heidelberg

    M. Lorenz, E. Biwer, M. Habs & D. Schmähl

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  1. M. Lorenz
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  2. E. Biwer
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  3. M. Habs
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  4. D. Schmähl
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Lorenz, M., Biwer, E., Habs, M. et al. Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch N-Nitroso-1,3-bis-(2-chloroethyl)-harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom. Langenbecks Arch Chiv 362, 253–261 (1984). https://doi.org/10.1007/BF01254653

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