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Characteristics of Organic Anion Binding Proteins from Rat Liver Sinusoidal Plasma Membranes

  • Conference paper
Hepatic Transport of Organic Substances

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Within the past decade it has become widely accepted that the entry into the hepatocyte of low molecular weight amphipathic organic compounds which are albumin-bound within the circulation is mediated by membrane proteins on the sinusoidal (basolateral) surface of the hepatocyte (Berk and Stremmel, 1986; Berk et al., 1 987; Frimmer and Ziegler, 1988). These proteins are presumed to be components of one or more specific transport systems. Precisely how these proteins participate in cellular uptake is, in most instances, unclear, and there is a considerable debate, between “lumpers” and “splitters”, as to how many such proteins there are, and how many different transport systems they serve. “Lumpers” argue for the existence of a very limited number of sinusoidal membrane transport systems of broad specificity; perhaps as few as one mediating sodium-dependent and another sodium-independent uptake of a wide spectrum of compounds which includes anions, cations and neutral compounds (Buscher et al, 1986).

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Author information

Authors and Affiliations

  1. Polly Annenberg Levee Hematology Center and Hepatic Research Group, Departments of Medicine and Biochemistry, Mount Sinai School of Medicine of the City University of New York, New York, NY, 10029, USA

    Paul D. Berk, Barry J. Potter, Dario Sorrentino, Decherd Stump, Chih-Li Kiang & Sheng-Li Zhou

  2. Medizinische Klinik D, Universität Düsseldorf, Federal Republic of Germany

    Wolfgang Stremmel

Authors
  1. Paul D. Berk
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  2. Barry J. Potter
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  3. Dario Sorrentino
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  4. Wolfgang Stremmel
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  5. Decherd Stump
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  6. Chih-Li Kiang
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  7. Sheng-Li Zhou
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Editor information

Editors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Universität Gießen, Frankfurter Straße 107, 6300, Gießen, Germany

    Ernst Petzinger

  2. Max-Planck-Institut für Systemphysiologie, Rheinlanddamm 201, 4600, Dortmund 1, Germany

    Rolf K. H. Kinne

  3. Institut für Physiologische Chemie I, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf 1, Germany

    Helmut Sies

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© 1989 Springer-Verlag Berlin Heidelberg

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Berk, P.D. et al. (1989). Characteristics of Organic Anion Binding Proteins from Rat Liver Sinusoidal Plasma Membranes. In: Petzinger, E., Kinne, R.K.H., Sies, H. (eds) Hepatic Transport of Organic Substances. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74247-7_21

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  • DOI: https://doi.org/10.1007/978-3-642-74247-7_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74249-1

  • Online ISBN: 978-3-642-74247-7

  • eBook Packages: Springer Book Archive

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