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Hepatic Transport of Organic Substances

  • Ernst Petzinger
  • Rolf K. H. Kinne
  • Helmut Sies
Conference proceedings

Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Table of contents

  1. Front Matter
    Pages I-XV
  2. General Aspects of Hepatic Transport

  3. Physiology, Pharmacology, and Biochemistry of Hepatic Transport Systems

    1. Front Matter
      Pages 119-119
    2. Hepatic Transport of Glutathione-Conjugates

      1. M. Huber, T. Baumert, A. Guhlmann, D. Mayer, D. Keppler
        Pages 131-140
      2. Curtis D. Klaassen, Zoltan Gregus
        Pages 141-153
    3. Hepatic Transport of Amino Acids

    4. Hepatic Transport of Organic Anions and Bile Acids

      1. Paul D. Berk, Barry J. Potter, Dario Sorrentino, Wolfgang Stremmel, Decherd Stump, Chih-Li Kiang et al.
        Pages 195-210
      2. Wolfgang Stremmel
        Pages 211-220
      3. B. L. Blitzer
        Pages 233-239
      4. B. Fleischer, F. A. Simion, S. Fleischer
        Pages 240-256
      5. F. J. Suchy, M. Ananthanarayanan, J. C. Bucuvalas
        Pages 257-266
      6. Gerhart Kurz, Michael Müller, Ursula Schramm, Wolfgang Gerok
        Pages 267-278
      7. A. Hoffmann, S. Müllner, K. Ziegler, H. Fasold
        Pages 301-302
    5. Hepatic Transport of Xenobiotics

    6. Hepatic Transport of Hormones

      1. Mary Vore, Arunee Changchit, Sherrie Durham, Steve Teo
        Pages 377-387
      2. F. Lauterbach, R.-P. Czekay, A. Fries, M. Schorn
        Pages 388-389
      3. E. P. Krenning, R. Docter, T. J. Visser, G. Hennemann
        Pages 390-402
      4. T. J. Visser, M. Rutgers, W. W. de Herder, S. J. Eelkman Rooda, M. P. Hazenberg
        Pages 403-404
  4. Concluding Remarks

    1. K. J. Ullrich
      Pages 405-410

About these proceedings

Introduction

Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the passage of metabolites to be released into different blood compartments. To perform vectorial passages hepatocytes show a strong polarity with sites for endocytotic processes or specific carrier molecules, and a specified system of organelles for intracellular transport and sorting, metabolization and secretion of compounds. Several aspects, e.g. regulation, control and mechanisms of hepatic traffic are reported in detail - complemented by methodological approaches to analyse and monitor these processes.

Keywords

ATP Activation Alanin Amino acid Glutamat Glutamin Monoclonal Antibodies Vivo biochemistry influence mercury metabolism physiology regulation

Editors and affiliations

  • Ernst Petzinger
    • 1
  • Rolf K. H. Kinne
    • 2
  • Helmut Sies
    • 3
  1. 1.Institut für Pharmakologie und ToxikologieUniversität GießenGießenGermany
  2. 2.Max-Planck-Institut für SystemphysiologieDortmund 1Germany
  3. 3.Institut für Physiologische Chemie IUniversität DüsseldorfDüsseldorf 1Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-74247-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1989
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-74249-1
  • Online ISBN 978-3-642-74247-7
  • Series Print ISSN 0172-6625
  • Buy this book on publisher's site