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Insulitis in the Human Pancreas

  • Chapter
The Pathology of the Endocrine Pancreas in Diabetes

Abstract

Most people interested in the pathogenesis of type 1 diabetes associate the term “insulitis” with one name — that of Willy Gepts. In what must be one of the most cited references in the diabetic literature, he showed that this lesion, comprising a predominantly chronic inflammatory cell infiltrate of the islets of Langerhans, was present in 15 of 22 patients who had died of “juvenile” diabetes within a year of presentation [13]. The lesion was not seen in diabetes of more prolonged duration.

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References

  1. Adams TE, Bodmer G, Bodmer WF (1983) Production and characterisation of monoclonal antibodies recognising the alpha chain subunits of human Ia alloantigens. Immunology 50: 613–624

    PubMed  CAS  Google Scholar 

  2. Alejandro R, Shienvold FL, Hajek SV, Ryan U, Miller J, Mintz DH (1982) Immunocytoehemical localization of HLA-DR in human islets of Langerhans. Diabetes 31: [Suppl 4] 17–22

    PubMed  Google Scholar 

  3. Bottazzo GF, Florin-Christensen A, Doniach D (1974) Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiences. Lancet 2:1279–1282

    Article  PubMed  CAS  Google Scholar 

  4. Bottazzo GF (1984) Beta-cell damage in diabetic insulitis: are we approaching a solution? Diabetologia 26: 241–249

    Article  PubMed  CAS  Google Scholar 

  5. Bottazzo GF, Pujol-Borrell R, Hanafusa T, Feldmann M (1983) Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 2: 1115–1118

    Article  PubMed  CAS  Google Scholar 

  6. Bottazzo GF, Dean BM, McNally JM, MacKay EH, Swift PGF, Gamble DR (1985) In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 313: 353–360

    Article  PubMed  CAS  Google Scholar 

  7. Bottazzo GF (1986) Death of a beta cell: homicide or suicide? Diabetic Med 3:119–130

    Article  PubMed  CAS  Google Scholar 

  8. Bottazzo GF, Todd I, Mirakian R, Belfiore A, Pujol-Borrell R (1986) Organ-specific autoimmunity: a 1986 overview. Immunol Rev 94: 137–169

    Article  PubMed  CAS  Google Scholar 

  9. Campbell IL, Bizilj K, Colman PG, Tuch BE, Harrison LC (1986) Interferon-gamma induces the expression of HLA-A, -B, -C but not HLA-DR on human pancreatic beta cells. J Clin Endocrinol Metab 62:1101–1109

    Article  PubMed  CAS  Google Scholar 

  10. Dobersen MJ, Scharff JE (1982) Preferential lysis of pancreatic Beta cells by islet cell surface antibodies. Diabetes 31: 459–462

    Article  PubMed  CAS  Google Scholar 

  11. Doniach I, Morgan AG (1973) Islet of Langerhans in juvenile Diabetes mellitus. Clin Endocrinol 2: 233–248

    Article  CAS  Google Scholar 

  12. Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS (1986) The histopathology of the pancreas in Type I (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 29: 267–274

    Article  PubMed  CAS  Google Scholar 

  13. Foulis AK, Farquharson MA (1986) Aberrant expression of HLA-DR antigens by insulin containing beta cells in recent onset Type I (insulin-dependent) diabetes mellitus. Diabetes 35: 1215–1224

    Article  PubMed  CAS  Google Scholar 

  14. Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14: 619–633

    PubMed  CAS  Google Scholar 

  15. Gepts W, De Mey J (1978) Islet cell survival determined by morphology — an immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus. Diabetes 27: [Suppl 1] 251–261

    PubMed  Google Scholar 

  16. Gorsuch AN, Spencer KM, Lister J, McNally JM, Dean BM, Bottazzo GF, Cudworth AG (1981) Evidence for a long prediabetic period in Type I (insulin-dependent) diabetes mellitus. Lancet 2:1363–1365

    Article  PubMed  CAS  Google Scholar 

  17. Hanafusa T, Pujol-Borrell R, Chiovato L, Russel RCG, Doniach D, Bottazzo GF (1983) Aberrant expression of HLA-DR antigen on thyrocytes in Graves’ disease. Relevance for autoimmunity. Lancet 2:1111–1115

    Article  PubMed  CAS  Google Scholar 

  18. Junker K, Egeberg S, Kromann H Nerup J (1977) An autopsy study of the islet of Langerhans in acute-onset juvenile diabetes mellitus. Acta Pathol Microbiol Scand [A] 85: 699–706

    CAS  Google Scholar 

  19. LeCompte PM (1958) “Insulitis” in early juvenile diabetes. Arch Pathol 66: 450–457

    CAS  Google Scholar 

  20. Lendrum R, Walker G, Cudworth AG, Theophanides C, Pyke DA, Bloom A, Gamble DR (1976) Islet-cell antibodies in diabetes mellitus Lancet 2:1273–1276

    Article  PubMed  CAS  Google Scholar 

  21. Londei M, Lamb JR, Bottazzo GF, Feldmann M (1984) Epithelial cells expressing aberrant MHC Class II determinants can present antigen to cloned human T cells. Nature 312: 639–641

    Article  PubMed  CAS  Google Scholar 

  22. Londei M, Bottazzo GF, Feldmann M (1985) Human T-cell clones from autoimmune thyroid glands: specific recognition of autologous thyroid cells. Science 228: 85–89

    Article  PubMed  CAS  Google Scholar 

  23. Natali PG, DeMartino CD, Quaranta V, Nicotra MR, Frezza F, Pellegrino MA, Ferrone S (1981) Expression of Ia-like antigens in normal human non-lymphoid tissues. Transplantation 31:75–78

    Article  PubMed  CAS  Google Scholar 

  24. Nerup J, Andersen OO, Bendixen G, Egeberg J, Poulsen JE (1971) Anti-pancreatic cellular hypersensitivity in diabetes mellitus. Diabetes 20: 424–427

    PubMed  CAS  Google Scholar 

  25. Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, Paquette TL (1983) Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222:1337–1339

    Article  PubMed  CAS  Google Scholar 

  26. Pujol-Borrell R, Hanafusa T, Chiovato L. Bottazzo GF (1983) Lectin-induced expression of DR antigen on human cultured follicular thyroid cells. Nature 304: 71–73

    Article  CAS  Google Scholar 

  27. Pujol-Borrell R, Todd I, Doshi M, Gray D, Feldmann M, Bottazzo GF (1986) Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas. Clin Exp Immunol 65:128–139

    PubMed  CAS  Google Scholar 

  28. Pujol-Borrell R, Todd I, Doshi M, Bottazzo GF, Sutton R, Gray D, Adolf GR, Feldmann M (1987) HLA Class II induction in human islet cells by Interferon-γ plus tumor necrosis factor or lymphotoxin. Nature 326: 304–306

    Article  PubMed  Google Scholar 

  29. Sai P, Kremer M, Nomballais MF, Aillet G (1984) Antibodies spontaneously bound to islet cells in Type I diabetes. Lancet 2: 233–234

    Article  PubMed  CAS  Google Scholar 

  30. Sibley RK, Sutherland DER, Goetz F, Michael AF (1985) Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest 53:132–144

    PubMed  CAS  Google Scholar 

  31. Todd I, Pujol-Borrell R, Hammond LJ, Bottazzo GF, Feldmann M (1985) Interferon-γ induces HLA-DR expression by thyroid epithelium. Clin Exp Immunol 61: 265–273

    PubMed  CAS  Google Scholar 

  32. Wolf E, Spencer KM, Cudworth AG (1983) The genetic susceptibility to Type 1 (insulin-dependent) diabetes: analysis of the HLA-DR association. Diabetologia 24: 224–230

    Article  PubMed  CAS  Google Scholar 

  33. Foulis AK, Farquharson MA, Hardman R (1987) Aberrant expression of class II major histocompatibility Complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in Type I (insulin-dependent) diabetes mellitus. Diabetologia 30: 333–343

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. A. K. Foulis
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  2. G. F. Bottazzo
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Editor information

Editors and Affiliations

  1. Division of Diabetes, Nutrition and Metabolic Disorders Department of Medicine, Centre Hospitalier Universitaire du Sart-Tilman, B-4000, Liège 1, Belgium

    Pierre J. Lefèbvre

  2. Dept. of Metabolism and Endocrinology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels, Belgium

    Daniel G. Pipeleers

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© 1988 Springer-Verlag Berlin Heidelberg

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Foulis, A.K., Bottazzo, G.F. (1988). Insulitis in the Human Pancreas. In: Lefèbvre, P.J., Pipeleers, D.G. (eds) The Pathology of the Endocrine Pancreas in Diabetes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72691-0_3

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  • DOI: https://doi.org/10.1007/978-3-642-72691-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72693-4

  • Online ISBN: 978-3-642-72691-0

  • eBook Packages: Springer Book Archive

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