The Pathology of the Endocrine Pancreas in Diabetes

  • Pierre J. Lefèbvre
  • Daniel G. Pipeleers

Table of contents

  1. Front Matter
    Pages I-XI
  2. P. J. Lefèbvre
    Pages 1-16
  3. A. K. Foulis, G. F. Bottazzo
    Pages 41-52
  4. Ä. Lernmark, H. Markholst, S. Baekkeskov
    Pages 53-70
  5. E. H. Leiter, G. L. Wilson
    Pages 85-105
  6. D. G. Pipeleers, P. A. In’t Veld, M. Van De Winkel
    Pages 106-124
  7. S. Falkmer, U. Askensten
    Pages 125-140
  8. C. Hellerström, I. Swenne, A. Andersson
    Pages 141-170
  9. G. Somers, M. De Vroede
    Pages 171-190
  10. E. Cerasi
    Pages 191-218
  11. P. A. In’t Veld
    Pages 233-248
  12. A. A. Like, E. J. Weringer
    Pages 269-284
  13. Back Matter
    Pages 329-336

About this book

Introduction

Diabetes mellitus represents one of the most frequent and serious clinical syn­ dromes in contemporary medicine. Since the end of the nineteenth century, the endocrine pancreas has been implicated in the pathogenesis of this disease. Several pathologists of the twentieth century detected various lesions and mor­ phologic alterations in the pancreatic islets of diabetic patients, but the patho­ physiologic basis of their findings remained long obscure. The systematic mi­ croscopic work of WILLY GEPTS clarified the views and related the variety in histopathology to differences in origin, duration and clinical expression of the disease. Over the past two decades, the concept of a multifactorial origin of diabetes has become widely accepted. Various agents and mechanisms have been identified which can lead to a quantitative or qualitative deficit in pancre­ atic B-cells. The purpose of this book is to bring an update on the many path­ ways which may induce an absolute or relative insufficiency in insulin release and hence a diabetic state. Rather than bringing a complete account on all re­ search relevant to the understanding of the pathology of the diabetic pancreas, the authors of the various chapters of this volume have focussed on selected processes which can impair B-cell function, survival or regeneration.

Keywords

Diabetes Diabetes mellitus Diabetic Pancreas Insulin Secretion Insulitis Pancreas Pancreatic Islets growth insulin pathogenesis pathology transplantation

Editors and affiliations

  • Pierre J. Lefèbvre
    • 1
  • Daniel G. Pipeleers
    • 2
  1. 1.Division of Diabetes, Nutrition and Metabolic Disorders Department of MedicineCentre Hospitalier Universitaire du Sart-TilmanLiège 1Belgium
  2. 2.Dept. of Metabolism and EndocrinologyVrije Universiteit BrusselBrusselsBelgium

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-72691-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-72693-4
  • Online ISBN 978-3-642-72691-0
  • About this book