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Biosynthesis of the Tetracyclines

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The Tetracyclines

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 78))

Abstract

Research on the biosynthesis of tetracyclines, which has developed rapidly since the discovery of chlortetracycline (Duggar 1948), oxytetracycline (Finlay et al. 1950), and the biological synthesis of tetracycline (Minieri et al. 1954), can be divided into several historical phases. The first tempestuous phase of the study of the technology of tetracycline fermentation occurred in the fifties; the results of studies from this period are surveyed in an excellent review by Di Marco and Pennella (1959). The sixties were characterized by the study of the building blocks and biosynthetic intermediates of tetracycline antibiotics; significant contribution in this field is due to the research team of the Lederle Laboratories headed by McCormick. Pertinent results from this period were published in several review articles (Hlavka and Boothe 1973; Mc Cormick 1967, 1969; Mitscher 1968). In the following decade, the study of tetracycline biosynthesis was focused on the elucidation of regulatory mechanisms in the biosynthesis and on deciphering the molecular nature of these processes.

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Authors
  1. Z. Hošťálek
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  2. Z. Vaněk
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Editors and Affiliations

  1. Medical Research Division, Lederle Laboratories, American Cyanamid Company, 10987, Pearl River, NY, USA

    J. J. Hlavka

  2. 418 E. Longport, P.O. Box 1004, 08740, Ocean Gate, NJ, USA

    J. H. Boothe

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Hošťálek, Z., Vaněk, Z. (1985). Biosynthesis of the Tetracyclines. In: Hlavka, J.J., Boothe, J.H. (eds) The Tetracyclines. Handbook of Experimental Pharmacology, vol 78. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70304-1_4

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