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Cytodifferentiation and Papaver Alkaloid Accumulation

  • Conference paper
The Chemistry and Biology of Isoquinoline Alkaloids

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

The latex found in many species of the Papaveraceae family is a remarkable biological fluid, not only because of its contents, the morphinan alkaloids, but also because of its unusual storage capacity. Latex arises upon articulation and anastamoses of the highly specialized laticifer cells present in these plants (Felklova and Babkova 1958, Fairbairn and Kapoor 1960). Laticifer cells appear as early as a few days after germination of P. bracteatum seedlings and these initial cells contain many vesicles with electron-dense caps (Nessler and Mahlberg 1978). Dissolution of transverse cell walls may be observed within a week after germination ultimately giving rise to networks of vessels. Latex in the ducts originates from the cell protoplasm.

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References

  • Battersby AR, Foulkes DM, Binks R (1965) Alkaloid biosynthesis, part VIII. Use of optically active precursors for investigations on the biosynthesis of morphine alkaloids. J Chem Soc: 3323–3332

    Google Scholar 

  • Battersby AR, Jones RGF, Kazlauskas R (1975) Experiments on the early steps of morphine biosynthesis. Tetrahedron Lett: 1873–1876

    Google Scholar 

  • Berlin J, Forche E, Wray V, Hammer J, Wolfgang H (1983) Formation of benzophenanthridine alkaloids by suspension cultures of Eschscholtzia californica. Z Naturforsch 38: 346–352

    Google Scholar 

  • Böhm H (1981) Papaver bracteatum Lindl. — Results and problems of the research on a potential medicinal plant. Pharmazie 36: 660–667

    Google Scholar 

  • Böhm H, Franke J (1982) Accumulation and excretion of alkaloids by Macleaya microcarpacell cultures. I. Experiments on solid medium. Biochem Physiol Pflanz 177: 345–356

    Google Scholar 

  • Böhm H, Olesch B, Schultze CH (1972) Further investigations on the biosynthesis of alkaloids in isolated latex from opium poppy, Papaver somniferum L. Biochem Physiol Pflanz 163: 126–136

    Google Scholar 

  • Boller TH, Kende H (1979) Hydrolytic enzymes in the central vacuole of plant cells. Plant Physio 163: 1112–1132

    Google Scholar 

  • Borkowski PR, Horn JS, Rapoport H (1978) Role of 1,2-dehydroreticulinium ion in the biosynthetic conversion of reticuline to thebaine. J Am Chem Soc 100: 276–281

    Article  CAS  Google Scholar 

  • Brossi A (1982) Mammalian TIQ’s: products of condensation with aldehydes or pyruvic acids? In: Bloom F, Barchas J, Sandler M, Usdin E (eds) Progress in clinical and biological research: Beta-carbolines and tetrahydroisoquinolines, vol 90. Liss, New York, p 125

    Google Scholar 

  • Cramer CL, Ristow JL, Paulus TJ, David RH (1983) Methods for mycelial breakage and isolation of mitochondria and vacuoles of Neurospora. Anal Biochem 128: 384–392

    Article  PubMed  CAS  Google Scholar 

  • Fahn A (1979) Secretory tissues in plants. Academic, London New York, pp 223–243

    Google Scholar 

  • Fairbairn JW, Kapoor LD (1960) Laticiferous vessels of Papaver somniferum. Planta Med 8: 49–61

    Article  CAS  Google Scholar 

  • Fairbairn JW, Steele MJ (1981) Biosynthetic and metabolic activities of some organelles in Papaver somniferum latex. Phytochemistry 20: 1031–1036

    Article  CAS  Google Scholar 

  • Fairbairn JW, Djote M, Paterson A (1968) The alkaloids of Papaver somniferum L.—VII. Biosynthetic activity of the isolated latex. Phytochemistry 7: 2111–2116

    Article  CAS  Google Scholar 

  • Felklova M, Babkova K (1958) Latex tubes in Papaver somniferum during the vegetative period. Pharmazie 13: 220

    PubMed  CAS  Google Scholar 

  • Franke J, Bühm H (1982) Accumulation and excretion of alkaloids by Macleaya microcarpa cell cultures. II. Experiments in liquid medium. Biochem Physiol Pflanz 177:501–507

    CAS  Google Scholar 

  • Ikuta A, Syono K, Furuya T (1974) Alkaloids of callus tissues and redifferentiated plantlets in the Papaveraceae. Phytochemistry 13: 2175–2179

    Article  CAS  Google Scholar 

  • Kamimura S, Nishikawa M (1976) Growth and alkaloid production of the cultured cells of Papaver bracteatum. Agric Biol Chem40: 907–911

    Article  CAS  Google Scholar 

  • Kamimura S, Akutsu M, Nishikawa M (1976) Formation of thebaine in the suspension culture of Papaver bracteatum. Agric Biol Chem40: 913–919

    Article  CAS  Google Scholar 

  • Kettenes-Van Den Bosch JJ, Salemink CA, Khan I (1981) Biological activity of the alkaloids of Papaver bracteatum Lindl. J Ethnopharmacol3: 21–38

    Article  Google Scholar 

  • Kutchan TM, Ayabe S, Krueger RJ, Coscia EM, Coscia CJ (1983) Cytodifferentiation and alkaloid accumulation in cultured cells of Papaver bracteatum. Plant Cell Rep2: 281–284

    Article  CAS  Google Scholar 

  • Matile P, Wiemken A (1974) Vacuoles and spherosomes. In: Fleischer S, Packer L (eds) Methods in enzymology, vol 31. Academic, London New York, p 572

    Google Scholar 

  • Nessler CL, Mahlberg PG (1978) Laticifer ultrastructure and differentiation in seedlings of Papa-ver bracteatumLindl., Population Arya II (Papaveraceae). Am J Bot 65: 978–983

    Article  Google Scholar 

  • Phillipson JD (1983) Infraspecific variation and alkaloids of Papaverspecies. J Med Plant Res (Planta Med) 48: 187–192

    Article  CAS  Google Scholar 

  • Roberts MF (1974) Oxidation of tyrosine by Papaver somniferumlatex. Phytochemistry 13: 119–123

    Article  CAS  Google Scholar 

  • Roberts MF, Antoun MD (1978) The relationship between L-DOPA decarboxylase in the latex of Papaver somniferumand alkaloid formation. Phytochemistry 17: 1083–1087

    Article  CAS  Google Scholar 

  • Roberts MF, McCarthy D, Kutchan TM, Coscia CJ (1983) Localization of enzyme and alkaloidal metabolites in Papaverlatex. Arch Biochem Biophys 222: 599–609

    Article  PubMed  CAS  Google Scholar 

  • Rueffer M, El Shagi H, Nagakura N, Zenk MH (1981) (S)-Norlaudanosoline synthetase: the first enzyme in the benzylisoquinoline biosynthetic pathway. FEBS Lett 129:5–9

    Article  CAS  Google Scholar 

  • Sasse F, Backs-Hüsemann D, Barz W (1979) Isolation and characterization of vacuoles from cell suspension cultures of Daucus carota. Z Naturforsch 34: 848–853

    Google Scholar 

  • Schuchmann R, Wellmann E (1983) Somatic embryogenesis of tissue cultures of Papaver somniferumand Papaver orientaleand its relationship to alkaloid and lipid metabolism. Plant Cell Rep 2: 88–91

    Article  CAS  Google Scholar 

  • Shamma M, Moniot JL (1978) Isoquinoline alkaloids research: 1972–1977. Plenum, New York London

    Google Scholar 

  • Spenser ID (1969) The biosynthesis of alkaloids and of other nitrogenous secondary metabolites. In: Florkin M, Stotz EH (eds) Comprehensive biochemistry, vol 20. Elsevier, Amsterdam New York, p 231 and references cited therein

    Google Scholar 

  • Wilson ML, Coscia CJ (1975) Studies on the early stages of Papaveralkaloid biogenesis. J Am Chem Soc 97: 431–433

    Article  PubMed  CAS  Google Scholar 

  • Yoshikawa T, Furuya T (1982) Morphinan alkaloid production by opium poppy suspension culture. In: Fujiwara A (ed) Proc 5th Int Congr Plant Tissue Cell Culture. Abe Printing, Tokyo, p 307

    Google Scholar 

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Author information

Authors and Affiliations

  1. E.A. Doisy Department of Biochemistry, St. Louis University School of Medicine, St. Louis, Missouri, 63104, USA

    C. J. Coscia

Authors
  1. T. M. Kutchan
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  2. S. Ayabe
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  3. C. J. Coscia
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Editor information

Editors and Affiliations

  1. Department of Pharmacognosy, The School of Pharmacy, Brunswick Square, WC1N 1AX, London, UK

    J. David Phillipson  & Margaret F. Roberts  & 

  2. Pharmazeutische Biologie, Universität München, Karlstraße 29, 8000, München 2, Germany

    M. H. Zenk

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© 1985 Springer-Verlag Berlin Heidelberg

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Kutchan, T.M., Ayabe, S., Coscia, C.J. (1985). Cytodifferentiation and Papaver Alkaloid Accumulation. In: Phillipson, J.D., Roberts, M.F., Zenk, M.H. (eds) The Chemistry and Biology of Isoquinoline Alkaloids. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70128-3_19

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  • DOI: https://doi.org/10.1007/978-3-642-70128-3_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70130-6

  • Online ISBN: 978-3-642-70128-3

  • eBook Packages: Springer Book Archive

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