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DNA Adducts and Their Biological Relevance

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Mutations in Man

Abstract

Epidemiologic studies of human carcinogenesis have demonstrated that exposure to certain chemicals significantly increases cancer risks. Additionally, the carcinogenic effects of chemicals have been observed in many animal experiments. As a result of these studies, strong regulations have been imposed worldwide to limit exposure to chemical carcinogens, primarily during occupational, and industrial exposure as well as restricting the use of potentially hazardous pharmaceutical products and dangerous food additives. Despite the efforts to minimize human exposure to chemical carcinogens, the abundance of these carcinogens in our natural environment implies that exposure to chemical carcinogens is not only a problem of industrialized civilization but is in fact inevitably associated with normal food consumption etc. The ubiquitous distribution of cancer-causing chemicals makes imperative the study of the biochemical mechanisms of chemical carcinogenesis.

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Authors and Affiliations

  1. Institut für Toxikologie der Universität, Obere Zahlbacher Str. 67, 6500, Mainz, Germany

    F. Oesch

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  1. G. Doerjer
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  2. M. A. Bedell
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  3. F. Oesch
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Editors and Affiliations

  1. Institut für Genetik, Freie Universität Berlin, Arnimallee 5-7, 1000, Berlin 33, Germany

    Günter Obe

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© 1984 Springer-Verlag Berlin Heidelberg

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Doerjer, G., Bedell, M.A., Oesch, F. (1984). DNA Adducts and Their Biological Relevance. In: Obe, G. (eds) Mutations in Man. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69530-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-69530-8_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69532-2

  • Online ISBN: 978-3-642-69530-8

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