Abstract
In order to detect the genotoxic effects of living in today’s complex industrialized society, we must devise sensitive ways to measure early subtle changes in human beings that may lead to more pathological effects in longer periods of time. The detection of mutational changes in somatic cells is a possible way of monitoring for effects that could ultimately lead to carcinogenic or heritable lesions. Depending on the lifespan of the somatic cells analyzed, the frequency of mutated somatic cells in an individual may be a measurement of the effects of recent toxic exposure or an indication of cumulative genetic insult.
Work performed under the auspices of the U.S. Department of Energy by the Lawrence Livermore National Laboratory under contract number W-7405-ENG-48, EPA Grant R808642–01, and USPHS Grant No. ROI CA 31549–01 awarded by the National Cancer Institute, DHHS
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© 1984 Springer-Verlag Berlin Heidelberg
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Jensen, R.H., Bigbee, W., Branscomb, E.W. (1984). Somatic Mutations Detected by Immunofluorescence and Flow Cytometry. In: Eisert, W.G., Mendelsohn, M.L. (eds) Biological Dosimetry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69334-2_15
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DOI: https://doi.org/10.1007/978-3-642-69334-2_15
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