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Morphofunctional Aspects of the Normal and Pathological Blood-Brain Barrier

  • Conference paper
Cerebrovascular Transport Mechanisms

Part of the book series: Acta Neuropathologica Supplementum ((NEUROPATHOLOGIC,volume 8))

Abstract

Compared with other organs of the body the brain and spinal cord show unique behaviour as far as the exchange of metabolites to and from the blood is concerned. This peculiarity has led to the concept of the so-called “blood-brain barrier” (BBB). The concept is useful not only when dealing with questions of metabolic exchange in general but more specifically for understanding the mechanism of the production of and the changes in the cerebral spinal fluid; the permeability of the brain for toxins, viruses and antibodies; and, finally, the capability of various drugs to reach the brain. The pathologist is often confronted with blood-brain barrier function since blood pigments appear in the cerebrospinal fluid in certain diseases. For example, in neonatal jaundice the yellow pigment reaches the orain because of an insufficiently developed blood-brain barrier; the phenomenon cannot be found in adults.

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Authors and Affiliations

  1. Institute of Neuropathology, Free University Berlin, Hindenburgdamm 45, 1000, Berlin 45, Germany

    J. Cervós-Navarro & J. Artigas

  2. Institute for Biological Research, University of Belgrade, Yugoslavia

    B. J. Mršulja

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  1. J. Cervós-Navarro
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  2. J. Artigas
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  3. B. J. Mršulja
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  1. Max-Planck-Institut für neurologische Forschung, Ostmerheimerstr. 200, D-5000, Köln, Federal Republic of Germany

    Konstantin-Alexander Hossmann

  2. Laboratory of Neuropathology and Neuroanatomical Sciences, NINCDS, National Institutes of Health, PHS, DHHS, Bethesda, Maryland, 20205, USA

    Igor Klatzo

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Cervós-Navarro, J., Artigas, J., Mršulja, B.J. (1983). Morphofunctional Aspects of the Normal and Pathological Blood-Brain Barrier. In: Hossmann, KA., Klatzo, I. (eds) Cerebrovascular Transport Mechanisms. Acta Neuropathologica Supplementum, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68970-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-68970-3_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12204-3

  • Online ISBN: 978-3-642-68970-3

  • eBook Packages: Springer Book Archive

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