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Interspecies Dosimetry of Reactive Gases

  • Conference paper
Inhalation Toxicology

Part of the book series: ILSI Monographs ((ILSI MONOGRAPHS))

Abstract

The development of dosimetry models that can provide a description of the uptake and distribution of inhaled compounds throughout the body is an integral component of the risk assessment process. The availability of such models allows for more informed judgments of potential risk from human exposure since toxicological data obtained in a variety of animal species using different exposure regimens can be compared to humans on the basis of dose delivered to the target site. This also enables information from studies that are comparable, from a delivered dose perspective, to be assessed collectively, thereby increasing the likelihood that the interpretation of the toxicological results will be correct. Knowledge of the respiratory tract dosimetry of inhaled reactive gases is particularly important since due to their reactivity, they often bind to target sites within the respiratory tract, causing toxicity.

The research described in this article has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

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Author information

Authors and Affiliations

  1. Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA

    F. J. Miller, J. H. Overton & T. R. Gerrity

  2. Environmental Sciences, Northrop Services Inc., Research Triangle Park, NC, 27709, USA

    R. C. Graham

Authors
  1. F. J. Miller
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  2. J. H. Overton
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  3. T. R. Gerrity
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  4. R. C. Graham
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Editor information

Editors and Affiliations

  1. Department of Veterinary Pathology, University of California, Davis, CA, 95616, USA

    Donald L. Dungworth Ph.D. M.R.C.V.S

  2. Bayer AG, Institute for Toxicology, 5600, Wuppertal-Elberfeld, Germany

    Georg Kimmerle Dr.med.

  3. Abbott Laboratories, Abbott Park, IL, 60064, USA

    James Lewkowski M.D.

  4. Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, P.O. Box 5890, Albuquerque, NM, 87185, USA

    Roger O. McClellan D.V.M.

  5. Fraunhofer Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Strasse 1, 3000, Hannover 61, Germany

    Werner Stöber Dr.rer.nat.

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© 1988 Springer-Verlag New York Inc.

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Miller, F.J., Overton, J.H., Gerrity, T.R., Graham, R.C. (1988). Interspecies Dosimetry of Reactive Gases. In: Dungworth, D.L., Kimmerle, G., Lewkowski, J., McClellan, R.O., Stöber, W. (eds) Inhalation Toxicology. ILSI Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61355-5_9

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  • DOI: https://doi.org/10.1007/978-3-642-61355-5_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64806-9

  • Online ISBN: 978-3-642-61355-5

  • eBook Packages: Springer Book Archive

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