Inhalation Toxicology

The Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment

  • Donald L. Dungworth
  • Georg Kimmerle
  • James Lewkowski
  • Roger O. McClellan
  • Werner Stöber

Part of the ILSI Monographs book series (ILSI MONOGRAPHS)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Approaches to Assessing the Toxicity of Airborne Toxicants

  3. Methodological Issues in Designing and Conducting Studies with Laboratory Animals

  4. Interpretation of Toxicokinetic Studies with Airborne Toxicants

    1. Front Matter
      Pages 138-138
    2. F. J. Miller, J. H. Overton, T. R. Gerrity, R. C. Graham
      Pages 139-155
  5. Interpretation of Results Using Laboratory Animals

About these proceedings

Introduction

The International Life Sciences Institute (ILSI), a nonprofit, public foundation, was established in 1978 to advance the sciences of nutrition, toxicology, and food safety. ILSI promotes the resolution of health and safety issues in these areas by sponsoring research, conferences, publications, and educational programs. Through ILSI's programs, scientists from government, academia, and industry unite their efforts to resolve issues of critical importance to the public. As part of its commitment to understanding and resolving health and safety issues, ILSI is pleased to sponsor this series of monographs that consolidates new scientific knowledge, defines research needs, and provides a background for the effective application of scientific advances in toxicology and food safety. Alex Malaspina President International Life Sciences Institute Contents Series Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi Part I. Approaches to Assessing the Toxicity of Airborne Toxicants Chapter 1. Standard-Setting as an Integrative Exercise: Alchemy, Juggling, or Science? . . . . . . . . . . . . . . . . . . . . . . . 1 D. v. Bates Chapter 2. Species Differences in Inhalation Toxicology: Variations in Exposure-Dose Relationships and Macrophage Function. . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 J. D. Brain Chapter 3. Cell Populations of the Respiratory System: Interspecies Diversity in Composition, Distribution, and Morphology . . . . . . . . . . . . . . . . . . . . . . . . 25 e. G. Plopper, A. Mir, J. St. George, N. Tyler, A. Mariassy, D. Wilson, S. Nishio, D. Cranz, J. Heidsiek, and D. Hyde Chapter 4. Comparative Metabolic Basis for the Disposition and Toxic Effects of Inhaled Materials . . . . . . . . . . . . . . . . . 41 A. R. Dahl Part II. Methodological Issues in Designing and Conducting Studies with Laboratory Animals Chapter 5. Exposure Facilities and Aerosol Generation and Characterization for Inhalation Experiments. . . . . . . . . .

Keywords

cell research toxicity toxicology

Editors and affiliations

  • Donald L. Dungworth
    • 1
  • Georg Kimmerle
    • 2
  • James Lewkowski
    • 3
  • Roger O. McClellan
    • 4
  • Werner Stöber
    • 5
  1. 1.Department of Veterinary PathologyUniversity of CaliforniaDavisUSA
  2. 2.Bayer AGInstitute for ToxicologyWuppertal-ElberfeldGermany
  3. 3.Abbott LaboratoriesUSA
  4. 4.Inhalation Toxicology Research InstituteLovelace Biomedical and Environmental Research InstituteAlbuquerqueUSA
  5. 5.Fraunhofer Institute of Toxicology and Aerosol ResearchHannover 61Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-61355-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64806-9
  • Online ISBN 978-3-642-61355-5
  • About this book