Abstract
In many mammals possessing the enzyme uricase purine is excreted mostly as allantoin (Table 1). In primates, including humans, which have lost the ability to convert urate to allantoin, uric acid/urate is the excreted substance (Greger et al. 1975). Two problems connected to the loss of uricase and to the exclusive excretion of uric acid and urate have developed in primates and, more specifically, humans: The first is the limited solubility of {tly|71-1} urate in body fluids, leading to gout; the other is the limited solubility of urate/uric acid in urine, leading to urolithiasis (Mertz 1975). Both phenomena have triggered research in the fields of purine biochemistry and renal uric acid excretion (Holmes, this volume; Kelley, this volume; Lang 1981).
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© 1989 Springer-Verlag Berlin Heidelberg
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Greger, R. (1989). Purine Excretion. In: Wolfram, G. (eds) Genetic and Therapeutic Aspects of Lipid and Purine Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61322-7_8
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DOI: https://doi.org/10.1007/978-3-642-61322-7_8
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