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Handling of uric acid by the rat kidney

II. Microperfusion studies on bidirectional transport of uric acid in the proximal tubule

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Summary

Under free flow conditions there is a net transport of uric acid in the rat proximal tubule. This net transport is the result of two unidirectional fluxes which in the range of normal plasma concentrations of uric acid follow a first order kinetic, i.e. the unidirectional fluxes are in linear proportion to uric acid concentration in tubular fluid or in plasma, respectively. The transport coefficient of the influx (in secretion direction) exceeds that of the outflux (in reabsorption direction) by a factor of 2.5.

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Authors and Affiliations

  1. Physiologisches Institut der Universität Innsbruck, Schoepfstr. 41, A-6020, Innsbruck, Austria

    F. Lang, R. Greger & P. Deetjen

  2. Physiologisches Institut der Universität München, Munich, Germany

    F. Lang, R. Greger & P. Deetjen

Authors
  1. F. Lang
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  2. R. Greger
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  3. P. Deetjen
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This study was partially supported by a grant of the Deutsche Forschungsgemeinschaft.

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Lang, F., Greger, R. & Deetjen, P. Handling of uric acid by the rat kidney. Pflugers Arch. 335, 257–265 (1972). https://doi.org/10.1007/BF00586216

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  • DOI: https://doi.org/10.1007/BF00586216

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