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Melatonin: Multiple Functions in Signaling and Protection

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Skin Cancer and UV Radiation

Abstract

In its classical role, melatonin acts as a chemical mediator of the signal darkness. It is produced by the pineal gland, from where it is preferentially released at night, either in response to norepinephrine (in mammals) or to the lack of inhibition by light (in non-mammalian vertebrates). In this regard, its function consists of the conveyance of photoperiodic information concerning both duration and circadian phase position of the night. This information is used by the circadian oscillator system, including a feedback to the circadian pacemaker in the suprachiasmatic nucleus, and, in seasonally breeding mammals, for temporal orientation within the year (Reiter 1980, 1991a,b, 1993; Arendt 1986; Binkley 1993).

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  1. Dermatologische Klinik der Ruhr-Universität Bochum, im St. Josef Hospital, Gudrunstraße 56, D-44791, Bochum, Germany

    Peter Altmeyer , Klaus Hoffmann  & Markus Stücker ,  & 

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Hardeland, R. (1997). Melatonin: Multiple Functions in Signaling and Protection. In: Altmeyer, P., Hoffmann, K., Stücker, M. (eds) Skin Cancer and UV Radiation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60771-4_22

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  • DOI: https://doi.org/10.1007/978-3-642-60771-4_22

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