Abstract
Plants belonging to the genus of Tripterygium (Celastraceae) are perennial vines. At least three representatives of this genus are found in China [1]:
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Hori H, Pang G-M, Harimaya K, Iitaka Y, Inayama S (1987) Isolation and structure of regelin and regelinol, new antitumor ursene-type triterpenoids from Tripterygium regelii. Chem Pharm Bull 35:2125–2128
Qian SZ (1987) Tripterygium wilfordii, a Chinese herb effective in male fertility regulation. Contraception 36:335–345
Liao N-G (1987) Leigongteng. In: Chang H-M, But PP-H, red. Pharmacology and Applications of Chinese Materia Medica. Singapore: World Scientific Publishing, pp. 1201–1207
Deng W-L (1987) Kunmingshanhaitang. In: Chang H-M, But PP-H, red. Pharmacology and Applications of Chinese Materia Medica. Singapore: World Scientific Publishing, pp.793–797
Xu W-Y, Zheng J-R, Lu X-Y (1985) Tripterygium in dermatologic therapy. Int J Dermatol 24:152–157
Tang W, Eisenbrand G (1992) Chinese drugs of plant origin. Chemistry, pharmacology, and use in traditional and modern medicine. Heidelberg: Springer-Verlag, pp.989–996
Beroza M (1951) Alkaloids from Tripterygium wilfordii Hook. – wilforine and wilfordine. J Am Chem Soc 73:3656–3659
Beroza M (1952) Alkaloids from Tripterygium wilfordii Hook: wilforgine and wilfortrine. J Am Chem Soc 74:1585–1588
Beroza M (1953) Alkaloids from Tripterygium wilfordii Hook. The structure of wilforine, wilfordine, wilforgine and wilfortrine. J Am Chem Soc 75:44–49
Beroza M (1953) Alkaloids from Tripterygium wilfordii Hook. Isolation and structure of wilforzine. J Am Chem Soc 75: 2136–2138
Beroza M (1963) Alkaloids from Tripterygium wilfordii Hook. The chemical structure of wilfordic and hydroxywilfordic acids. J Org Chem 28:3562–3564
Zheng YL, Xu Y, Lin JF (1989) Immunosuppressive effects of wilfortrine and euonine. Acta Pharm Sin 24:568–72
He Z-S, Hong S-H, Li Y, Sha H, Yu X-G (1985) Structure of a new alkaloid wilforidine from Tripterygium wilfordii. Acta Chim Sin 43:593–596
Deng F-X, Cao J-H, Xia Z-L, Lin S, Wang X-Y (1987) Studies on the sesquiterpene alkaloids of Tripterygium wilfordii Hook. f. Acta Bot Sin 29:523–526
Kupchan SM, Hintz HPJ, Smith RM, Karim A, Cass MW, Court WA, Yatagai M (1974) Celacinnine, a novel macrocyclic spermidine alkaloid prototype. J Chem Soc Chem Comm pp.329–330
Kupchan SM, Hintz HPJ, Smith RM, Karim A, Cass MW, Court WA, Yatagai M (1977) Macrocyclic spermidine alkaloids from Maytenus serrata and Tripterygium wilfordii. J Org Chem 42:3660–3664
Takaishi Y, Ujita K, Noguchi H, Nakano K, Tomimatsu T, Kadota S, Tsubono K, Kikuchi T (1987) Structures of triptofordinine A-1 and A-2 determined by two-dimensional NMR spectroscopy. Highly esterified sesquiterpene alkaloids from Tripterygium wilfordii Hook fil. var. regelii Makino. Chem Pharm Bull 35:3534–3537
Kupchan SM, Court WA, Dailey RG Jr, Gilmore CJ, Bryan RF (1972) Triptolide and tripdiolide: novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J Am Chem Soc 94:7194–7195
Ma PC, Lu XY, Yang JJ, Zheng QT (1991) 16-Hydroxytriptolide, a new active diterpene isolated from Tripterygium wilfordii. Acta Pharm Sin 26:759–763
Zheng J (1991) Screening of active anti-inflammatory, immunosuppressive and antifertility components of Tripterygium wilfordii. III. A comparison of the anti-inflammatory and immunosuppressive activities of 7 diterpene lactone epoxide Compounds in vivo. Acta Acad Med Sin 13:391–397
Lu X (1990) The isolation and structure of tripchlorolide (T4) from Tripterygium wilfordii. Acta Acad Med Sin 12:157–161
Chen K, Shi QA, Fujioka T, Zhang D-C, Hu C-Q, Jin J-Q, Kilkuskie RE, Lee K-H (1992) Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation. J Nat Prod 55:88–92
Matlin SA, Belenguer A, Stacey VE, Qian SZ, Xu Y, Zhang JW, Sanders JKM, Amor SR, Pearce CM (1993) Male antifertility Compounds from Tripterygium wilfordii Hook f. Contraception 47:387–400
Zhang CP, Lu XY, Ma PC, Chen Y, Zhang YG, Yan Z, Chen GF, Zheng QT, He CH, Yu DQ (1993) Studies on diterpenoids from leaves of Tripterygium wilfordii. Acta Pharm Sin 28:110–115
Van Tamelen EE, Demers JP, Taylor EG, Koller K (1980) Total synthesis of 1-triptonide and 1-triptolide. J Am Chem Soc 102:5424–5425
Van Tamelen EE, Leiden TM (1982) Biogenetic-type total synthesis of (±)-triptonide and (±)-triptolide. J Am Chem Soc 104:1785–1786
Buckanin RS, Chen SJ, Frieze DM, Sher FT, Berchtold GA (1980) Total synthesis of triptolide and triptonide. J Am Chem Soc 102:1200–1201
Kutney JP, Beale MH, Salisbury PJ, et al. (1980) Tripdiolide from tissue culture of Tripterygium wilfordii. Heterocycles 14:1465–1467
Kutney JP, Hewitt GM, Kurihara T, et al. (1981) Cytotoxic diterpenes triptolide, tridiolide, and cytotoxic triterpenes from tissue cultures of Tripterygium wilfordii. Can J Chem 59:2677–2683
Zhang CP (1989) Studies on triterpenoids of total glucosides of Tripterygium wilfordii (T II). Acta Acad Med Sin 11:322–325
Zhang D-M, Yu D-Q, Xie F-Z (1991) The structure of tripterygone. Acta Pharm Sin 26:341–344
Bryan RF, Fallon L (1976) Crystal structure of syringaresinol. J Chem Soc Perkin Trans 2:341–345
Xia ZL, Huang SQ, Chen JY, Deng FX (1989) A new anthraquinone Compound from the stem and leaves of Tripterygium wilfordii Hook f. China J Chin Materia Medica 14:675-676 and 703
Qian S-Z, Hu Y-Z, Wang S-M, Luo Y, Tang A-S, Shu S-Y, Zhou J-W, Rao T-Y (1988) Effects of Tripterygium hypoglaucum (Lévl.) Hutch on male fertility. Adv Contracep 4:307–310
Zhou B-N (1991) Some progress on the chemistry of natural bioactive terpenoids from Chinese medicinal plants. Mem Inst Oswaldo Cruz 86 (Suppl 2):219–226
Zhang L, Zhang ZX, An DK, Kong C (1991) Studies on the chemical constituents of Tripterygium hypoglaucum (Lévl) Hutch. Acta Pharm Sin 26:515–518
Zhang L, Zhang ZX, Sheng LS, An DK, Lu Y, Zheng QT, Wang SC (1992) Study on the chemical constituents of Tripterygium hypoglaucum (Lévl.) Hutch. Acta Pharm Sin 28:32–34
Pang G-M, Zhao C-J, Hori H, Inayama S (1989) Studies on new triterpenoids of Tripterygium regelii. Acta Pharm Sin 24:75–79
Hegnauer R (1964) Chemotaxonomie der Pflanzen. Band 3: Dicotyledoneae: Acanthaceae – Cyrillaceae. Basel: Birkhäuser Verlag, pp.398–399
Takaishi Y, Ujita K, Nakano K, Murakami K, Tomimatsu T (1987) Sesquiterpene esters from Tripterygium wilfordii Hook fil. var. regelii, structures of triptofordins A-C-l. Phytochemistry 26:2325–2329
Takaishi Y, Ujita K, Kida K, Shibuya M, Tomimatsu T (1987) Polyhydroxyagarofuran derivatives from Tripterygium wilfordii H. Phytochemistry 26:2581–2584
Takaishi Y, Ujita K, Nakano K, Tomimatsu T (1988) Structural elucidation of triptofordins F-l, F-2, F-3, and F-4, new sesquiterpenes polyesters from Tripterygium wilfordii Hook fil. var. regelii Makino. Chem Pharm Bull 36:4275–4283
Takaishi Y, Noguchi H, Murakami K, Nakano K, Tomimatsu T (1990) Sesquiterpene esters, triptogelin A-l-A-4, from Tripterygium wilfordii var. regelii. Phytochemistry 29:3869–3873
Takaishi Y, Tokura K, Tamai S, Noguchi H, Nakano K, Tomimatsu T (1991) Sesquiterpene esters from Tripterygium wilfordii. Phytochemistry 30:1561–1566
Takaishi Y, Tokura K, Tamai S, Ujita K, Nakano K, Tomimatsu T (1991) Sesquiterpene polyol esters from Tripterygium wilfordii var. regelii. Phytochemistry 30:1567–1572
Takaishi Y, Tamai S, Nakano K, Murakami K, Tomimatsu T (1991) Structures of sesquiterpene polyol esters from Tripterygium wilfordii var. regelii. Phytochemistry 30:3027–3031
Li X-W, Weir MR (1990) Radix Tripterygium wilfordii-a Chinese herbal medicine with potent immunosuppressive properties. Transplantation 50:82–86
Tao X, Davis LS, Lipsky PE (1991) Effect of an extract of the Chinese herbal remedy Tripterygium wilfordii Hook f on human immune responsiveness. Arthritis Rheum 34:1274–1281
Zhang X-Y, Tsuchiya N, Dohi M, Yamamoto K, Ishihara K, Okudaira H, Ito K, Miyamoto T (1992) Prolonged survival of MRL-lpr/lpr mice treated with Tripterygium wilfordii Hook-f. Clin Immunol Immunopathol 62:66–71
Su D, Song Y, Li R (1990) Comparative clinical study of rheumatoid arthritis treated by triptolide and an ethyl acetate extract of Tripterygium wilfordii. Chin J Modern Develop Trad Med 10:144-146 and 131
Yu D-Y (1983) Clinical Observation of 144 cases of rheumatoid arthritis treated with glycoside of Radix Tripterygium wilfordii. J Tradit Chin Med 3:125–129
Tao X-L, Sun Y, Dong Y et al. (1989) A prospective, controlled, double-blind, cross-over study of Tripterygium wilfordii Hook f in treatment of rheumatoid arthritis. Chin Med J 102:327–332
Lan Z-J, Gu Z-P, Lu R-F, Zhuang L-Z (1992) Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells. Contraception 45:249–261
Guo J-L, Yuan S-X, Wang X-C, Xu S-X, Li D-D (1981) Tripterygium wilfordii Hook f in rheumatoid arthritis and ankylosing Spondylitis. Preliminary report. Chin Med J 94:405–412
Shu H-Y, Liu P-L, Huang G-Y (1984) Effects of Tripterygium wilfordii on the menstruation of 50 patients suffering from rheumatoid arthritis-with a summary of its therapeutic effects in 12 cases of menorrhagia. J Trad Chin Med 4:237–240
Guo J-L, Gao Z-G, Zang A-C, Bai R-X (1986) Radix Tripterygium wilfordii Hook f in rheumatoid arthritis, ankylosing Spondylitis and juvenile rheumatoid arthritis. Chin Med J 99:317–320
Qin W-Z, Liu C-H, Yang S, et al. (1981) Tripterygium wilfordii Hook f in systemic lupus erythematosus. Report of 103 cases. Chin Med J 94:827–834
Wang BX, Yuan ZZ (1989) A tablet of Tripterygium wilfordii in treating lupus erythematosus. Chin J Modern Develop Trad Med 9:407-408 and 389
Qin W-Z, Zhu G-D, Yang S-M, Han K-Y, Wang J (1983) Clinical observations on Tripterygium wilfordii in treatment of 26 cases of discoid lupus erythematosus. J Trad Chin Med 3:131–132
Tripterygium Wilfordii Hook f Research Group (1984) Studies on total glycosides of Tripterygium wilfordii Hook f in dermatoses. Chin Med J 97:667–670
Gu W-Z, Brandwein SR, Banerjee S (1992) Inhibition of type II collagen induced arthritis in mice by an immunosuppressive extract of Tripterygium wilfordii Hook f. J Rheumatol 19:682–688
Li L-S (1989) Medical progress in China. An overview of nephrology in China. Chin Med J 102:488–495
Kao NL, Richmond GW, Moy JN (1993) Resolution of severe lupus nephritis associated with Tripterygium wilfordii Hook F ingestion. Arthritis Rheum 36:1751–1752
Jiang X (1994) Clinical observations on the use of the Chinese herb Tripterygium wilfordii Hook for the treatment of nephrotic Syndrome. Pediatr Nephrol 8:343–344
Tao X-L, Dai H, Ye W, Zhang N-Z (1989) The effect of T2 on in vitro PGE2, IgG and IgM production of PBMC of normal individuals and patients with RA. Arthritis Rheum 32 (suppl): S131
Ye WH (1990) Mechanism of treating rheumatoid arthritis with polyglycosides of Tripterygium wilfordii Hook (T II). III. Study on inhibitory effect of T II on in vitro Ig secreted by peripheral blood mononuclear cells from normal controls and RA patients. Acta Acad Med Sin 12:217–222
Jiang M et al. (1992) The effect of glycoside Tripterygium wilfordii Hook F on the immune regulatory function of T lymphocyte. Nat Med J China 72:473-475 and 509–510
Gu W-Z, Banerjee S, Rauch J, Brandwein SR (1992) Suppression of renal disease and arthritis, and Prolongation of survival in MRL-lpr mice treated with an extract of Tripterygium wilfordii Hook f. Arthritis Rheum 35:1381–1386
Xu WM, Zhang LX, Cheng ZH, Cai WZ, Miao HH, Pan DJ (1991) Inhibitory effect of tripterine on activities of IL-1, IL-2 and release of PGE2. Acta Pharm Sin 26:641–645
Yu DF, Hu BH, Chen GP, Yang CX, Yang J, Xu JY, Li LZ (1990) Structure revision of triptophenolide. Acta Pharm Sin 25:929–31
Kupchan SM (1976) Novel plant-derived tumor inhibitors and their mechanisms of action. Cancer Treatment Rep 60:1115–1126
Zhang T-M, Chen Z-Y, Lin C (1981) Antineoplastic action of triptolide and its effect on the immunologic functions in mice. Acta Pharmacol Sin 2:128–131
Takaishi Y, Ujita K, Tokuda H, Nishino H, Iwashima A, Fujita T (1992) Inhibitory effects of dihydroagarofuran sesquiterpenes on Epstein-Barr virus activation. Cancer Lett 65:19-26 and 67:215
Ujita K, Takaishi Y, Tokuda H, Nishino H, Iwashima A, Fujita T (1993) Inhibitory effects of triptogelin A-l on 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor promotion. Cancer Lett 68:129–133
Chen K, Shi Q, Kashiwada Y, et al (1992) Anti-AIDS agents, 6. Salaspermic acid, an anti-HTV principle from Tripterygium wilfordii, and the structure-activity correlation with its related Compounds. J Nat Prod 55:340–346
Chen M-F, Zhang Q-Y, Yao J, Wu Z-Y, Shen R, Wang X-Y, Zhang H-X, Zhu J-G, Zhen Z-H, Chen J-Z (1983) Treatment of chronic nephritis with Tripterygium hypoglaucum. A clinical and experimental study. J Trad Chin Med 3:219–222
Tao X, Sun Y, Zhang N (1990) Treatment of rheumatoid arthritis with low doses of multiglycosides of Tripterygium wilfordii. Chin J Mod Develop Trad Med 10:289-291, 261–262
Zhang Y-G, Huang G-Z, Wang H-J, Wu Z-B, Xing S-L (1984) An experimental pathological study of acute Lei Gong Teng (Tripterygium wilfordii Hook) intoxication in rats. Acta Acad Med Wuhan 4:75–81
Cheng Y-L, Ye J-R, Lin D-J; Lin L-J, Zhu J-N (1981) Some toxicities of triptolide in mice and dogs. Acta Pharmacol Sin 2:70–72
Zhang Y-G, Huang G-Z (1988) Poisoning by toxic plants in China. Report of 19 autopsy cases. Am J Forens Med Pathol 9:313–319
Gu CX (1989) Cause of amenorrhea after treatment with Tripterygium wilfordii F. Acta Acad Med Sin 11:151–153
Qian S-Z, Zhong C-Q, Xu Y (1986) Effect of Tripterygium wilfordii Hook.f. on the fertility of rats. Contraception 33:105–110
Zheng J (1991) Screening of active anti-inflammatory, immunosuppressive and antifertility components of Tripterygium wilfordii. IV. A comparison of the male antifertility activities of 7 diterpene lactone epoxide Compounds. Acta Acad Med Sin 13:398–403
Qian S-Z, Zhong CQ, Xu Y (1986) Studies on the reversibility of the antifertility effect of Tripterygium wilfordii Hook. f. (GTW) in male SD rats. Adv Contracep 2:298
Ye W (1991) Antispermatogenic effects of multiglycosides of Tripterygium wilfordii and monomer T4 in the testes and epididymal spermatozoa of rats. Acta Acad Med Sin 13:235–240
Qian S-Z, Wang S-M, Wang Y, Xu Y (1988) Studies of the effect of Tripterygium hypoglaucum (Level.) Hutch on the fertility of male rats. Adv Contracep 4:53–54
Qian S-Z, Zhong C-Q, Xu N, Xu Y, Ni L-Q, Feng G-Z (1986) The antifertility effect of total glycosides of Tripterygium wilfordii Hook.f. (GTW) in men. Adv Contracep 2:253–254
Wang X, Zhuo R, He Z (1993) Aneuploidy induction by water extract from Tripterygium hypoglaucum (Level) Hutch in mouse bone marrow cells. Mutagenesis 8: 395–398
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De Smet, P.A.G.M. (1997). Tripterygium Species. In: De Smet, P.A.G.M., Keller, K., Hänsel, R., Chandler, R.F. (eds) Adverse Effects of Herbal Drugs. Adverse Effects of Herbal Drugs, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60367-9_14
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