Abstract
A preparation of extracts from the root of the Chinese medicinal herbTripterygium wilfordii Hook was administered orally at a dose of 1 mg/kg body weight per day to 13 children with idiopathic nephrotic syndrome. Eight children, including 4 who were steroid resistant, went into remission which was maintained in 4 for up to 3 years after withdrawal of treatment. In 3 children the proteinuria lessened with the return of plasma protein concentration to normal, and in 1 child this improvement was maintained for 4 years after treatment ceased. No serious side-effects were noted, but a temporary anti-fertility activity has been noted in other studies of both men and women.
References
Zhang Xiao-qun, Zhang Zhao-he (1989) The immunosuppressive actions ofTripterygium wilfordii hook (a review). Shanghai J Immunol 9: 314–316
Lu Xie-yu, Ma Peng-cheng, Chen yun, Zhang Chong-pu, Zhang Yong-gang, Zhang Zheng-xing, Sheng Long-sheng, Li Shi-zhuang, An Deng-kui, He Cun-heng, Zheng Qi-tai (1990) The isolation and structure of tripchlorolide (T4) fromTripterygium wilfordii. Acta Acad Med Sin 12: 157–161
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jiang, X. Clinical observations on the use of the Chinese herbTripterygium wilfordii Hook for the treatment of nephrotic syndrome. Pediatr Nephrol 8, 343–344 (1994). https://doi.org/10.1007/BF00866356
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00866356