Skip to main content
SpringerLink
Log in

Metabolic Targets of Cancer Chemoprevention: Interruption of Tumor Development by Inhibitors of Arachidonic Acid Metabolism

  • Conference paper
Chemoprevention of Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 151))

Abstract

Tumor promotion is understood as a process that favors the clonal outgrowth of single mutated (initiated) cells to premalignant lesions through co-mitogenic and anti-apoptotic effects. This process can be evoked by repeated induction of a regenerative tissue response as achieved either by irritation and wounding or by agents (tumor promoters) that interact with the corresponding pathways of cellular signaling. Metabolic processes regulated by such pathways and essential for tumor development are potential targets of cancer chemoprevention. Examples are provided by the expression of ornithine decarboxylase and the activation of eicosanoid formation from arachidonic acid. Arachidonic acid metabolism is a particularly attractive and important target of chemopreventive measures. Its induction is a characteristic response to tissue damage and irritation and an apparently critical event in epithelial tumor promotion. Inhibitors of eicosanoid formation, such as nonsteroidal anti-inflammatory drugs, rank among the most powerful chemopreventive agents in animal models and have been shown to halve the incidence of colorectal cancer in man. Recently, the role of cyclooxygenase-2 (COX-2)-catalyzed prostaglandin synthesis has been the subject of much attention. COX-2 is a typical ‘ emergency enzyme’, since in most tissues it is transiently induced only in the course of repair and defense reactions. In epithelial neoplasia, i.e. in skin and colorectal tumors, the enzyme is constitutively overexpressed along different molecular pathways, and it seems to be critically involved in tumor promotion. Consequently, specific COX-2 inhibitors have been shown to exhibit considerable cancer chemopreventive potential. The putative role of other pathways of arachidonic acid metabolism in tumor promotion and malignant progression is presently under investigation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ames BN, Gold LS, Willett WC (1995) The causes and prevention of cancer. Proc Natl Acad Sci USA 92:5258–5265.

    Article  PubMed  CAS  Google Scholar 

  • Balmain A, Brown K (1988) Oncogene activation in chemical carcinogenesis. Adv Cancer Res 51:147–182.

    Article  PubMed  CAS  Google Scholar 

  • Basu A (1993) The potential of PKC as a target for anticancer treatment. Pharmacol Ther 59:257–280.

    Article  PubMed  CAS  Google Scholar 

  • Berkowitz EA, Hissong MA, Lee DC (1996) Transcriptional and post-transcriptional induction of the TGFa gene in transformed rat liver epithelial cells. Oncogene 12:1991–2002.

    PubMed  CAS  Google Scholar 

  • Brown K, Kemp C, Burns P, Balmain A (1994) Importance of genetic alterations in tumour development. Arch Toxicol Suppl 16:253–260.

    PubMed  CAS  Google Scholar 

  • Castonguay A, Rioux N (1997) Inhibition of lung tumorigenesis by sulindac: comparison of two experimental protocols. Carcinogenesis 18:491–496.

    Article  PubMed  CAS  Google Scholar 

  • Coffey RJ, Graves-Deal R, Dempsey PJ, Whitehead RH, Pittelkow MR (1992) Differential regulation of transforming growth factor alpha autoinduction in a nontransformed and transformed epithelial cell. Cell Growth Differ 3:347–354.

    PubMed  CAS  Google Scholar 

  • Denhardt DT (1996) Signal-transducing protein phosphorylation cascades mediated by Ras/ Rho proteins in the mammalian cell: the potential from multiplex signaling. Biochem J 318:729–747.

    PubMed  CAS  Google Scholar 

  • Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W (1996) The PPARa-leukotriene B4 pathway to inflammation control. Nature 384:39–43.

    Article  PubMed  CAS  Google Scholar 

  • DiGiovanni J (1992) Multistage carcinogenesis in mouse skin. Pharmacol Ther 54:63–128.

    Article  Google Scholar 

  • Dominey AM, Wang XJ, King LE, Nanney LB, Gagne TA, Sellheyer K, Bundman DS, Longley MA, Rothnagel JA, Greenhalgh DA (1993) Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous papillomas. Cell Growth Differ 4:1071–1082.

    PubMed  CAS  Google Scholar 

  • Dong Z, Huang C, Brown RE, Ma WY (1997) Inhibition of activator protein 1 activity and neoplastic transformation by aspirin. J Biol Chem 272:9962–9970.

    Article  PubMed  CAS  Google Scholar 

  • Dove WF, Gould KA, Luango C, Moser AR, Shoemaker AR (1995) Emergent issues in the genetics of intestinal neoplasia. Cancer Surv 25:335–355.

    PubMed  CAS  Google Scholar 

  • DuBois RN, Radhika A, Reddy BS, Entingh AJ (1996) Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors. Gastroenterology 110:1259–1262.

    Article  Google Scholar 

  • Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN (1994) Up-regulation of cyclooxygenase-2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107:1183–1188.

    PubMed  CAS  Google Scholar 

  • Fischer SM, Mills GD, Slaga TJ (1982) Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism. Carcinogenesis 3:1243–1245.

    Article  PubMed  CAS  Google Scholar 

  • Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM (1995) 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte differentiation factor PPARy. Cell 83:803–812.

    Article  PubMed  CAS  Google Scholar 

  • Fry DW (1994) Protein tyrosine kinases as therapeutic targets in cancer chemotherapy and recent advances in the development of new inhibitors. Exp Opin Invest Drugs 3:577–595.

    Article  CAS  Google Scholar 

  • Fürstenberger G, Marks F (1983) Growth stimulation and tumor promotion in skin. J Invest Dermatol 81:157s–162s.

    Article  PubMed  Google Scholar 

  • Fürstenberger G, Kopp-Schneider A (1995) Malignant progression of papillomas induced by the initiation-promotion protocol in NMRI mouse skin. Carcinogenesis 16:61–69.

    Article  PubMed  Google Scholar 

  • Fürstenberger G, Czuk-Glänzer BI, Marks F, Keppler D (1994) Phorbol ester-induced leukotriene biosynthesis and tumor promotion in mouse epidermis. Carcinogenesis 15:2823–2827.

    Article  PubMed  Google Scholar 

  • Fürstenberger G, Rogers M, Schnapke R, Bauer G, Höfler P, Marks F (1989 a) Stimulatory role of transforming growth factors in multistage skin carcinogenesis: possible explanation for the tumor-inducing effect of wounding in initiated NMRI mouse skin. Int J Cancer 43:915–921.

    Article  PubMed  Google Scholar 

  • Fürstenberger G, Gross M, Marks F (1989 b) Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion). Carcinogenesis 10:91–96.

    Article  PubMed  Google Scholar 

  • Gao X, Honn KV (1995) Biological properties of 12(S)-HETE in cancer metastasis. Adv Prostaglandin Thromboxane Leukot Res 23:439–444.

    PubMed  CAS  Google Scholar 

  • Gaya SB, Rees AJ, Lechler RI, Williams G, Mason PD (1995) Malignant disease in patients with long-term renal transplants. Transplantation 59:1705–1709.

    Article  PubMed  CAS  Google Scholar 

  • Goetz EJ, An S, Zeng L (1995) Specific suppression by prostaglandin E2 of activation-induced apoptosis of human CD4+CD8+ T lymphoblasts. J Immunol 154:1041–1047.

    Google Scholar 

  • Gibbs JB, Oliff A (1994) Pharmaceutical research in molecular oncology. Cell 79:193–198.

    Article  PubMed  CAS  Google Scholar 

  • Glasgow WC, Hui R, Everhart AL, Jayawickreme, Angerman-Stewart J, Han BB, Eling TE (1997) The linoleic acid metabolite, 13(S)-hydroxyoctadecadienoic acid, augments the epidermal growth factor receptor signaling pathway by attenuation of receptor dephosphorylation. Differential response in Syrian hamster embryo tumor suppressor phenotypes. J Biol Chem 272:19269–19276.

    CAS  Google Scholar 

  • Glick AB, Sporn MB, Yuspa SH (1991) Altered regulation of TGF-beta 1 and TGF alpha in primary keratinocytes and papillomas expressing v-Ha-ras. Mol Carcinog 4:210–219.

    Article  PubMed  CAS  Google Scholar 

  • Glover MT, Deeks JJ, Raftery MJ, Cunningham J, Leigh IM (1997) Immunosuppression and risk of non-melanoma skin cancer in renal transplant recipients. Lancet 349:398.

    Article  PubMed  CAS  Google Scholar 

  • Grant S, Jarvis WD (1996) Modulation of drug-induced apoptosis by interruption of the protein kinase C signal transduction pathway: a new therapeutic strategy. Clin Cancer Res 2:1915–1920.

    PubMed  CAS  Google Scholar 

  • Grasso P, Sharratt M, Cohen AJ (1991) Role of persistent, non-genotoxic tissue damage in rodent cancer and relevance to humans. Annu Rev Pharmacol Toxicol 31:253–287.

    Article  PubMed  CAS  Google Scholar 

  • Gschwendt M, Fürstenberger G, Leibersperger H, Kittstein W, Lindner D, Rudolph C, Barth H, Kleinschroth J, Marmé D, Schächtele C, Marks F (1995) Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester TPA on mouse skin in vivo. Carcinogenesis 16:107–111.

    Article  PubMed  CAS  Google Scholar 

  • Gumbiner BM (1995) Signal transduction by ß-catenin. Curr Opin Cell Biol 7:634–640.

    Article  PubMed  CAS  Google Scholar 

  • Gumbiner BM (1997) A balance between ß-catenin and APC. Curr Biol 7:R443–R446.

    Article  PubMed  CAS  Google Scholar 

  • Hanif R, Pittas A, Feng Y, Koutsos MI, Qiao L, Staiano-Coico L, Shiff SI, Rigas B (1996) Effects of nonsteroidal antiinflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem Pharmacol 52:237–245.

    Article  PubMed  CAS  Google Scholar 

  • Hershman HR (1996) Prostaglandin synthase 2. Biochim Biophys Acta 1299:125–140.

    Google Scholar 

  • Imamoto A, Beltran LM, DiGiovanni J (1991) Evidence for autocrine/paracrine growth stimulation by transforming growth factor-alpha during the process of skin tumor promotion. Mol Carcinog 4:52–60.

    Article  PubMed  CAS  Google Scholar 

  • Kargman S, O’Neill G, Vickers P, Evans J, Mancini J, Jothy S (1995) Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res 55:2556–2559.

    PubMed  CAS  Google Scholar 

  • Karin M, Liu Z, Zandi E (1997) AP-1 function and regulation. Curr Opin Cell Biol 9:240–246.

    Article  PubMed  CAS  Google Scholar 

  • Kast R, Fürstenberger G, Marks F (1991) Activation of a keratinocyte phospholipase A 2 by bradykinin and 4ß -phorbol 12-myristate 13-acetate. Eur J Biochem 202:941–950.

    Article  PubMed  CAS  Google Scholar 

  • Kast R, Fürstenberger G, Marks F (1993) Activation of a cytosolic phospholipase A 2 by transforming growth factor a in HEL-30 keratinocytes. J Biol Chem 268:16795–16802.

    PubMed  CAS  Google Scholar 

  • Kelloff GJ, Boone CW, Crowell JA, Steele VE, Lubet R, Sigman CC (1994) Chemopreventive drug development: Perspectives and progress. Cancer Epidemiol Biomarkers Prev 3:85–98.

    PubMed  CAS  Google Scholar 

  • Kinzler KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87:159–170.

    Article  PubMed  CAS  Google Scholar 

  • Klein SB, Fisher GJ, Jensen TC, Mendelsohn J, Voorhees JJ, Elder JT (1992) Regulation of TGF-alpha expression in human keratinocytes: PKC-dependent and -independent pathways. J Cell Physiol 151:326–336.

    Article  PubMed  CAS  Google Scholar 

  • Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83:813–819.

    Article  PubMed  CAS  Google Scholar 

  • Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehmann JM (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc Natl Acad Sci USA 94:4318–4323.

    Article  PubMed  CAS  Google Scholar 

  • Kopp E, Gosh S (1994) Inhibition of NF-kB sodium salicylate and aspirin. Science 265:956–959.

    Article  PubMed  CAS  Google Scholar 

  • Krieg P, Kinzig A, Ress-Löschke M, Vogel S, Vanlandingham B, Stephan M, Lehmann WD, Marks F, Fürstenberger G (1995) 12-Lipoxygenase isoenzymes in mouse skin tumor development. Mol Carcinog 14:118–129.

    Article  PubMed  CAS  Google Scholar 

  • Krishnan K, Brenner DE (1994) Nonsteroidal anti-inflammatory drugs (NSAIDs) in colorectal cancer chemoprevention. Cancer J 10:10–16.

    Google Scholar 

  • Kutchera W, Jones DA, Matsunami N, Groden J, Mclntyre TM, Zimmerman GA, White RL, Prescott SM (1996) Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. Proc Natl Acad Sci 93:4816–4820.

    Article  PubMed  CAS  Google Scholar 

  • Levitzki A (1992) Tyrphostins: tyrosine kinase blockes as novel antiproliferative agents and dissectors of signal transduction. FASEB J 6:3275–3282.

    PubMed  CAS  Google Scholar 

  • Levitzki A (1994) Signal-transduction therapy. Eur J Biochem 226:1–13.

    Article  PubMed  CAS  Google Scholar 

  • Levitzki A (1996) Targeting signal transduction for disease therapy. Curr Opin Cell Biol 8:239–244.

    Article  PubMed  CAS  Google Scholar 

  • Levy GN (1997) Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer. FASEB J 11:234–247.

    PubMed  CAS  Google Scholar 

  • Lin LL, Wartmann M, Lin AY, Knopf JL, Seth A, Davis RJ (1993) cPLA2 is phosphorylated and activated by MAPkinase. Cell 72:269–278.

    Article  PubMed  CAS  Google Scholar 

  • Linardopoulos S, Street AJ, Quelle DE, Parry D, Peters G, Sherr CJ, Balmain A (1995) Deletion and altered regulation of p l6 (INK4a) and p l5 (INK4b) in undifferentiated mouse skin tumors. Cancer Res 55:5168–5172.

    PubMed  CAS  Google Scholar 

  • Marcus AJ (1995) Aspirin as prophylaxis against colorectal cancer. N Engl J Med 333:656–658.

    Article  PubMed  CAS  Google Scholar 

  • Marks F, Fürstenberger G (1995) Tumor promotion in skin. In: Arcos JC (ed) Chemical induction of cancer. Birkhäuser, Boston, pp 125–160.

    Google Scholar 

  • Marks F, Gschwendt M (1995) Protein kinase C and skin tumor promotion. Mutat Res 333:161–172.

    PubMed  CAS  Google Scholar 

  • Marks F, Fürstenberger G, Heinzelmann T, Müller-Decker K (1995) Mechanisms in tumor promotion: guidance for risk assessment and cancer chemoprevention. Toxicol Lett 82/83:907–917.

    Article  CAS  Google Scholar 

  • Marks F, Gschwendt M (1996) Protein kinase C. In: Marks F (ed) Protein phosphorylation. VCH, Weinheim, pp 81–116.

    Chapter  Google Scholar 

  • Marks F, Müller-Decker K, Fürstenberger G (1998) Eicosanoids as endogenous mediators of carcinogenesis and reporters of skin toxicity: cancer chemoprevention by inhibitors of arachidonic acid metabolism. In: Reiss C, Parvez H (eds) Advances in molecular toxicology (1996–97). VSP International Science Press, Zeist.

    Google Scholar 

  • Marnett LJ (1992) Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res 52:5575–5589.

    PubMed  CAS  Google Scholar 

  • Marnett LJ (1994) Generation of mutagens during arachidonic acid metabolism. Cancer Metastasis Rev 13:303–308.

    Article  PubMed  CAS  Google Scholar 

  • Marnett LJ (1995) Aspirin and related nonsteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer. Prev Med 24:103–106.

    Article  PubMed  CAS  Google Scholar 

  • Masferrer JL, Zweifel BS, Manning PT, Hauser SO, Leaky KM, Smith WG, Isakson PC, Seibert K (1994) Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci USA 91:3228–3282.

    Article  PubMed  CAS  Google Scholar 

  • Mestre JR, Subbaramaiah K, Sacks PG, Schantz SP, Tanabe T, Inoue H, Dannenberg AJ (1997) Retinoids suppress phorbol ester-mediated induction of cyclooxygenase-2. Cancer Res 57:1081–1085.

    PubMed  CAS  Google Scholar 

  • Müller-Decker K, Scholz K, Marks F, Fürstenberger G (1995) Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis. Mol Carcinog 12:31–41.

    Article  PubMed  Google Scholar 

  • Nakadate T, Yamamoto S, Iseki H, Sonoda S, Takemura S, Ura A, Hosoda Y, Kato R (1982) Inhibition of TPA-induced tumor promotion by nordihydroguaiaretic acid, a lipoxygenase inhibitor, and p -bromophenacyl bromide, a phospholipase A2 inhibitor. Gann 73:841–843.

    PubMed  CAS  Google Scholar 

  • Nakadate T, Yamamoto S, Aizu E, Kato R (1984) Effects of flavonoids and antioxidants on 12–0-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds. Gann 75:214–222.

    PubMed  CAS  Google Scholar 

  • Narumiya S (1996) Prostanoid receptors and signal transduction. Prog Brain Res 113:231–241.

    Article  PubMed  CAS  Google Scholar 

  • Naumann U, Hoffmeyer A, Flory E, Rapp UR (1996) Raf protein serine/threonine kinases.In: Marks F (ed) Protein phosphorylation. VCH, Weinheim, pp 203–236.

    Chapter  Google Scholar 

  • O’Brian CA, Ward NE, Ioannides CG, Dong Z (1992) Potential strategies of chemoprevention through modulation of protein kinase C activity. In: Steele VE, Boone CW, Stoner GD, Kelloff GJ (eds) Cellular and molecular targets for chemoprevention. CRC Press, Bocan Raton, pp 161–172.

    Google Scholar 

  • Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF, Taketo MM (1996) Suppression of intestinal polyposis in APCΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87:803–809.

    Article  PubMed  CAS  Google Scholar 

  • Pegg AE, Shantz LM, Coleman CS (1995) Ornithine decarboxylase as a target for chemoprevention. J Cell Biochem Suppl 22:132–138.

    Article  PubMed  CAS  Google Scholar 

  • Pentland AP, Masferrer J, Hale P, Gresham A, Buckman S (1997) Induction of COX-2 by UVB: potential role in the development of human skin cancer. J Invest Dermatol 108:547.

    Google Scholar 

  • Pepellenbosch MP, Qui RG, de Vries-Smits AMM, Tertoolen LGJ, deLaat SW, McCormick F, Hall A, Symons MH, Bos JL (1995) Rac mediates growth factor-induced arachidonic acid release. Cell 81:849–856.

    Article  Google Scholar 

  • Petrusevska RT, Fürstenberger G, Marks F, Fusenig N (1988) Cytogenetic effects caused by phorbol ester tumor promoters in primary mouse keratinocyte cultures: correlation with the convertogenic activity of TPA in multistage skin carcinogenesis. Carcinogenesis 9:1207–1215.

    Article  PubMed  CAS  Google Scholar 

  • Pica F, Franzese O, D’Onofrio C, Bonmassar E, Favalli C, Garaci E (1996) Prostaglandin E2 induces apoptosis in resting immature and mature human lymphocytes: a c-myc-dependent and Bcl-2 independent associated pathway. J Pharmacol Exp Ther 277:1793–1800.

    PubMed  CAS  Google Scholar 

  • Portella G, Liddell J, Crombie R, Haddow S, Clarke M, Stoler AB, Balmain A (1994) Molecular mechanisms of invasion and metastasis during mouse skin tumor progression. Invasion Metastasis 14:1–6.

    Google Scholar 

  • Powis G (1994) Signaling pathways as targets for anticancer drug development. Pharmacol Ther 62:57–95.

    Article  PubMed  CAS  Google Scholar 

  • Prescott SM, White RL (1996) Self-promotion? Intimate connections between APC and prostaglandin H synthase-2. Cell 87:783–786.

    Article  PubMed  CAS  Google Scholar 

  • Qiao L, Kozoni V, Tsioulias GJ, Koutsos MI, Hanif R, Shiff SJ, Rigas B (1995) Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo. Biochim Biophys Acta 14:215–223.

    Google Scholar 

  • Reddy BS, Rao CV, Seibert K (1996) Evaluation of cycloocygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. Cancer Res 56:4566–4569.

    PubMed  CAS  Google Scholar 

  • Saiagh S, Rigal D, Monier JC (1994) Effects of PGE2 upon differentiation and programmed cell death of suspension cultured CD4-CD8-thymocytes. Int J Immunopharmacol 16:775–786.

    Article  PubMed  CAS  Google Scholar 

  • Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, Kimura S, Kato H, Kondo M, Hla T (1995) Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res 55:3785–3789.

    PubMed  CAS  Google Scholar 

  • Schreinemachers DM, Everson RB (1994) Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 5:138–146.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz M (1995) Tumor promotion in liver. In: Arcos JC (ed) Chemical induction of cancer. Birkhäuser, Boston, pp 161–179.

    Google Scholar 

  • Schwenger P, Bellosta P, Vietor I, Basilico C, Skolnik EY, Vilcek J (1997) Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation. Proc Natl Acad Sci USA 94:2869–2873.

    Article  PubMed  CAS  Google Scholar 

  • Seger R, Krebs EG (1995) The MAPK signaling cascade. FASEB J 9:726–735.

    PubMed  CAS  Google Scholar 

  • Shaw IC, Jones HB (1994) Mechanisms of non-genotoxic carcinogenesis. Trends Pharmacol Sci 15:89–93.

    Article  PubMed  CAS  Google Scholar 

  • Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morrow J, Beauchamp RD, DuBois RN (1997) Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest 99:2254–2259.

    Article  PubMed  CAS  Google Scholar 

  • Slaga TJ (1995) Inhibition of the induction of cancer by anti-oxidants. Adv Exp Med Biol 369:167–174.

    PubMed  CAS  Google Scholar 

  • Tang DG, Chen JQ, Honn KV (1996) Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proc Natl Acad Sci USA 93:5241–5246.

    Article  PubMed  CAS  Google Scholar 

  • Tiano H, Chulada P, Spalding J, Lee C, Loftin C, Mahler J, Morham S, Langenbach R (1997) Effects of cyclooxygenase deficiency on inflammation and papilloma development in mouse skin. Proc Am Assoc Cancer Res 38:257.

    Google Scholar 

  • Treisman R (1996) Regulation of transcription by MAPkinase cascades. Curr Opin Cell Biol 8:205–215.

    Article  PubMed  CAS  Google Scholar 

  • Tsujii M, DuBois RN (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2. Cell 83:493–501.

    Article  PubMed  CAS  Google Scholar 

  • Tsujii M, Kawano S, DuBois RN (1997) Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sei USA 94:3336–3340.

    Article  CAS  Google Scholar 

  • Vassar R, Hutton ME, Fuchs E (1992) Transgenic overexpression of TGFa bypasses the need for c-Ha-ras mutations in mouse skin tomorigenesis. Mol Cell Biol 12:4643–4653.

    PubMed  CAS  Google Scholar 

  • Verma AK (1990) Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase. Basic Life Sei 52:195–204.

    CAS  Google Scholar 

  • Verma AK, Hsieh JT, Pong PC (1988) Mechanisms involved in ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate, a potent mouse skin tumor promoter and an activator of protein kinase C. Adv Exp Med Biol 250:273–290.

    PubMed  CAS  Google Scholar 

  • Walker BA, Rocchini C, Boone RH, Jacobson MA (1997) Adenosine A2a receptor activation delays apoptosis in human neutrophils. J Immunol 158:2926–2931.

    PubMed  CAS  Google Scholar 

  • Wang HG, Rapp UR, Reed JC (1996) Bcl-2-targets the protein kinase Raf-1 to mitochondria. Cell 87:1–20.

    Article  CAS  Google Scholar 

  • Waterman WH, Molski TF, Huang CK, Adams JL, Sha’afi RI (1996) Tumour necrosis factor-alpha-induced phosphorylation and activation of cytosolic phospholipase A 2 are abrogated by an inhibitor of the p38 mitogen-activated protein kinase cascade in human neutrophils. Biochem J 319:17–20.

    PubMed  CAS  Google Scholar 

  • Weinstein IB (1988) Strategies for inhibiting multistage carcinogenesis based on signal transduction pathways. Mutat Res 202:413–420.

    PubMed  CAS  Google Scholar 

  • Williams CS, Luongo C, Radhika A, Zhang T, Lamps LW, Nanney LB, Beauchamp RD, DuBois RN (1996) Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastoenterology 111:1134–1140.

    Article  CAS  Google Scholar 

  • Wiseman H, Halliwell B (1996) Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory diseases and progression to cancer. Biochem J 313:17–29.

    PubMed  CAS  Google Scholar 

  • Yoshizawa SH, Fujiki, Sugori H, Suganuma M, Nakayasu M, Matsushima R, Sugimura T (1990) Tumor-promoting activity of staurosporine, a potent protein kinase inhibitor, on mouse skin. Cancer Res 50:4974–4978.

    PubMed  CAS  Google Scholar 

  • Yu K, Bayonna W, Kallen CB, Harding HP, Ravera CP, McMahon G, Brown M, Lazar MA (1995) Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem 270:23975–23983.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Tumor Cell Regulation, Department B 0500, German Cancer Research Center, D-69120, Heidelberg, Germany

    F. Marks, G. Fürstenberger & K. Müller-Decker

Authors
  1. F. Marks
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Fürstenberger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Müller-Decker
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Center for Tumordetection and Prevention, Rorschacherstrasse 150, CH-9006, St. Gallen, Switzerland

    Hans-Jörg Senn

  2. European Institute of Oncology, Via Ripamonti, I-20141, Milan, Italy

    Alberto Costa M.D.

  3. Robert H. Lurie Cancer Center Breast Cancer Research Program, Olson Pavilion, Northwest-University Medical School, 503 E. Chicago Ave., 60611, Chicago, IL, USA

    V. Craig Jordan

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin · Heidelberg

About this paper

Cite this paper

Marks, F., Fürstenberger, G., Müller-Decker, K. (1999). Metabolic Targets of Cancer Chemoprevention: Interruption of Tumor Development by Inhibitors of Arachidonic Acid Metabolism. In: Senn, HJ., Costa, A., Jordan, V.C. (eds) Chemoprevention of Cancer. Recent Results in Cancer Research, vol 151. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59945-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59945-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64192-3

  • Online ISBN: 978-3-642-59945-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation